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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | The aroma of Brazilian ambarella fruit (Spondias cythereu Sonnerat) 显示文摘 | Fraga S R G Rezende C M | 2001 | Journal of Essential Oil Research2001，13，： | 1 |
| 3 | Pulmonary involvement in ankylosing spondylitis显示文摘 | SAMPAIO - BARROS P D CERQUEIRA E M REZENDE S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 4 | Pollution by hexachlo-robenzene and pentachlorophenol in the coastat plain of Sāo Paulo state显示文摘 | Nascimento N R Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，34： | 1 |
| 5 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state, Brazil 显示文摘 | do Nascimento N R Nicola S M C Rezende M 0 O | 2004 | Geoderma2004，121，34： | 1 |
| 6 | Ni-Zn nanoferrite for radar-absorbing material显示文摘 | LIMA U R NASAR M C NASAR R S REZENDE M C ARAUJO J H | 2008 | Journal of Magnetism and Magnetic Materials2008，320，10： | 1 |
| 7 | Seintigraphic imaging using technetium-99m-labeled ceftizoxlme in an experimental model of acute osteomyelitis in rats显示文摘 | DINIZ S O REZENDE C M SERAKIDES R | 2008 | Nucl Med Commun2008，29，9： | 1 |
| 8 | Device physics - magnetoelectronics 显示文摘 | Machado F L A Silva B L Rezende S M | 1994 | J Appl Phys1994，75，： | 1 |
| 9 | Identi- fication and characterization of antigenic proteins potentially expressed during the infectious process of Paracoccidioides brasiliensis显示文摘 | Dantas S F I M de Rezende T C V Bailo A M | 2009 | Microbes and Infection2009，11，10： | 1 |
| 10 | Effect of voidcontent on the moisture absorption in polymeric composites 显示文摘 | Costa M L Rezende M C Almeida S F M | 2006 | Polymer-Plastics Technology and Engineering2006，45，6： | 1 |
| 11 | Pulmonary involement in ankylosing spondylitis 显示文摘 | Sampaio P D Cerqueira E M Rezende S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 12 | Reactive doping of PAniCSA and its use in conducting coatings显示文摘 | R Faez M C Rezende | 1992 | SPIE Electronics Lett1992，，28： | 1 |
| 13 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state,Brazil显示文摘 | Nascimento N R D Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，1： | 1 |
| 14 | 显示文摘 | Machade F L A Rezende S M | 1994 | I Appl Phys1994，75，： | 1 |
| 15 | Giant magnetoimpedancein the ferromagnet CoT0-x FexSils B10 alloys显示文摘 | MACHAIX) F L A MARTINS C S REZENDE S M | 1995 | Phys Rev B1995，51，： | 1 |
| 16 | Pulmonary involement in ankylosing spondylitis 显示文摘 | Sampaio P D Cerqueira E M Rezende S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 17 | Effect of void con tent on the moisture absorption in polymeric composites显示文摘 | Costa M L Rezende M C De Almeida S F M | 2006 | Polymer-Plastics Technology and Engineering2006，45，6： | 1 |
| 18 | The influence of porosity on the interlaminar shear strength of carbon/epoxy and carbon/bismaleimide fabric laminates 显示文摘 | Costa M L de Almeicta S F M Rezende M C | 2001 | Composites Science and Technology2001，61，14： | 1 |
| 19 | Vitamin D receptor haplotypes affect lead levels during pregnancy显示文摘 | Rezende V B Amaral J H Quintana S M | 2010 | Sci Total Environ2010，408，21： | 1 |
| 20 | Pharmacokinetics and tolerance of transdermal fentanyl administration in foals显示文摘 | Eberspacher E Stanley S D Rezende M | 2008 | Veterinary Anaesthesia and Analgesia2008，535，3： | 1 |
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