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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Performance and yield stability of maize hybrids in stress-prone environments in eastern Africa显示文摘Identification and deployment of high-yielding and stress-tolerant maize hybrids adapted to stress-prone agro-ecologies is important for improving the food security and livelihoods of smallholder farmers in eastern Africa.The objectives of this study were to(i)assess the performance of maize hybrids under well-watered and drought stress conditions;(ii)evaluate grain yield stability of 65 intermediate-maturing and 55 early-maturing hybrids in 24 well-watered locations and seven drought stress locations;and(iii)identify representative and/or discriminative testing locations for increasing genetic gains for the target traits.There were significant differences for grain yield among early-and intermediatematuring hybrids tested under well-watered and drought stress environments.Among the early-maturing hybrids,the top 10 hybrids produced 46.8%–73.9%and 31.2%–42.1%higher mean grain yields than the best commercial check under drought and well-watered conditions,respectively.Among the intermediate-maturing hybrids,the top 10 hybrids produced 25.2%–47.7%and 8.5%–13.5%higher grain yield than commercial checks under drought stress and well-watered conditions,respectively,suggesting improvement in the levels of drought tolerance in both early-and intermediate-maturing hybrids.GGE biplot analysis and a bi-segmented regression linear method identified specific early-maturing and intermediate-maturing hybrids that performed well under both well-watered and drought stress conditions.These hybrids could be recommended for commercial production in eastern Africa.Kakamega in Kenya was found to be the most representative and highly discriminating site among well-watered testing locations,while Kabuku in Tanzania was the least representative of test locations.For testing under drought stress conditions,Kiboko in Kenya was identified as the most representative location.This information could be useful for allocating resources and streamlining CIMMYT maize hybrid testing in eastern Africa. | Wender Santos Rezende Yoseph Beyene Stephen Mugo Eric Ndou Manje Gowda Julius Pyton Sserumaga Godfrey Asea Ismail Ngolinda McDonald Jumbo Sylvester O.Oikeh Michael Olsen Aluízio Borém Cosme Damião Cruz Boddupalli M.Prasanna | 2020 | The Crop Journal2020，8，1： | 2 |
| 3 | Muttimodal MRI-Based Study in Patients with SPG4 Mutationse 显示文摘 | Rezende TJ de Albuquerque M Lamas GM | 2015 | PLoS On2015，10，01： | 1 |
| 4 | The aroma of Brazilian ambarella fruit (Spondias cythereu Sonnerat) 显示文摘 | Fraga S R G Rezende C M | 2001 | Journal of Essential Oil Research2001，13，： | 1 |
| 5 | Synthesis of copper chromite catalyst 显示文摘 | Kawamoto A M Pardini L C Rezende L C | 2004 | Aerospace Science and Technology2004，8，7： | 1 |
| 6 | Optimisation and validation of a quantitative and confirmatory LC-MS method for multi-residue analyses ofβ-lactam and tetracycline antibiotics in bovine muscle显示文摘 | REZENDE C P ALMEIDA M P BRITO R B | 2012 | Food Addit Contam Part A Chem Anal Control Expo Risk Assess2012，29，4： | 1 |
| 7 | CD4(+) CD25 (+)T regulatory cells do not transfer oral tolerance to peanut aller- gens in a mouse model of peanut allergy显示文摘 | Marcondes Rezende M Hassing I Bol-Schoenmakers M | 2011 | Clin Exp Allergy2011，41，9： | 1 |
| 8 | American trypanosomiasis(Chagas disease) 显示文摘 | Rassi A J Rassi A Rezende J M | 2012 | Infect Dis Clin N Am2012，26，： | 1 |
| 9 | Pulmonary involvement in ankylosing spondylitis显示文摘 | SAMPAIO - BARROS P D CERQUEIRA E M REZENDE S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 10 | Pollution by hexachlo-robenzene and pentachlorophenol in the coastat plain of Sāo Paulo state显示文摘 | Nascimento N R Nicola S M C Rezende M O O | 2004 | Geoderma2004，121，34： | 1 |
| 11 | Cyclic AMP enhances resolution of allergic pleurisy by promoting inflammatory cell apoptosis via inhibition of PI3K/Akt and NF-kappaB显示文摘 | Sousa L P Carmo A F Rezende B M | 2009 | Biochem Pharmacol2009，78，4： | 1 |
| 12 | Osteopenia: a bone disorder associated with diabetes mellitus 显示文摘 | Duarte V M Ramos A M Rezende L A | 2005 | J Bone Miner Metab2005，23，1： | 1 |
| 13 | Head and neck cancer:proteomic advances and biomarker achievements显示文摘 | Rezende TM de Souza Freire M Franco OL | 2010 | Cancer2010，116，21： | 1 |
| 14 | Pollution by hexachlorobenzene and pentachlorophenol in the coastal plain of Sao Paulo state, Brazil 显示文摘 | do Nascimento N R Nicola S M C Rezende M 0 O | 2004 | Geoderma2004，121，34： | 1 |
| 15 | Osteopenia:a bone disorder associated with diabetes mellitus显示文摘 | DURATE V M RAMOS A M REZENDE L A | 2005 | Journal of Bone and Mineral Metabolism2005，23，1： | 1 |
| 16 | Chemical and morphological characterization of sugarcane bagasse submitted to a delignification process for enhanced enzymatic digestibility 显示文摘 | REZENDE C A de LIMA M A MAZIERO P DEAZEVEDO E R GARCIA W POLIKARPOV L | 2011 | Biotechnology for Biofuels2011，4，1： | 1 |
| 17 | The value of inducing sputum on the diagnosis of tuberculous pleuritis 显示文摘 | CONDE M B LOIVOS A C REZENDE V M | 2003 | Amer J Respir Crit Care Med2003，167，3： | 1 |
| 18 | Ni-Zn nanoferrite for radar-absorbing material显示文摘 | LIMA U R NASAR M C NASAR R S REZENDE M C ARAUJO J H | 2008 | Journal of Magnetism and Magnetic Materials2008，320，10： | 1 |
| 19 | Transarterial embolisation of intracranial dural arteriovenous malformations with ethylene vinyl alcohol copolymer (Onyx18 ) 显示文摘 | Toulgoat F Mounayer C Tulio Salles Rezende M | 2006 | J Neuroradiol2006，33，2： | 1 |
| 20 | Seintigraphic imaging using technetium-99m-labeled ceftizoxlme in an experimental model of acute osteomyelitis in rats显示文摘 | DINIZ S O REZENDE C M SERAKIDES R | 2008 | Nucl Med Commun2008，29，9： | 1 |
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