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| 1 | Radical polymerization of N-显示文摘 | JY Ai PS Liu HY Tan RG Lei | 2001 | J App PolymSci2001，8，2： | 1 |
| 2 | Role of Sox2 in the development of the mouse neocortex 显示文摘 | Bani-Yaghoub M Tremblay RG Lei JX | 2006 | Dev Biol2006，295，1： | 1 |
| 3 | Role of Sox2 in the development of the mouse neoeortex显示文摘 | Bani-Yaghoub M Tremblay RG Lei iX | 2006 | Dev Biol2006，295，： | 1 |
| 4 | Role of Sox2 in the development of the mouse neocortex显示文摘 | Bani-Yaghoub M Tremblay RG Lei JX | | 0，，01： | 1 |
| 5 | Effect of Molecular Structure on the Performance of Polyacrylic Acid Superplasticizer显示文摘 | Zhang RG Guo HL Lei JH | 2008 | Journal of Wuhan University of Technology-Material Science Edition2008，22，2： | 1 |
| 6 | WHO Working Group on Revision of the Manual of Laboratory Methods for Testing DTP Vaccines-report of two meetings held on 20-21 July 2006 and 28-30 March 2007, Geneva, Switzerland 显示文摘 | Corbel M J Das RG Lei D | 2008 | Vaccine2008，26，16： | 1 |
| 7 | MicroRNA-149 Regulates Proliferation,Migration,and Invasion of Pituitary Adenoma Cells by Targeting ADAM12 and MMP14显示文摘Objective Pituitary adenomas(PAs)can adapt an aggressive phenotype by invading adjacent brain structures with rapid cellular proliferation.Previous studies demonstrated that excessive expression of metalloproteases ADAM12 and MMP-14 is instrumental for the active proliferation and invasiveness of PA cells in vitro and of tumors in vivo.However,the mechanisms regulating ADAM12 and MMP-14 expression in PAs remain unclear.Methods Target gene prediction and transcriptomic profiling of invasive vs.noninvasive human PA samples were performed to identify miRNA species potentially involved in the regulation of ADAM12 and MMP14.For cellular analyses of miRNA functions,two mouse PA cell lines(AtT20 and TtT/GF)were transfected with miR-149-3p and miR-149-5p,respectively.The effects of miR-149(3p and 5p)on expression levels of ADAM12 and MMP14 were determined by Western blotting followed by an analysis of proliferation and colony formation assays,scratch migration assays,and invasion assays.Results A significant downregulation of miRNA-149 was observed in invasive vs.noninvasive PA(0.32 vs.0.09,P<0.0001).In AtT-20 and TtT/GF mouse PAs cells,transfection of mimic miRNA-149(3p and 5p)caused a significantly reduced cell proliferation and matrigel invasion,whilst the effect on cell migration was less pronounced.Both strands of miRNA-149(3p and 5p)markedly reduced protein levels of ADAM12 and MMP-14 by at least 40%in both cell lines.Conclusion This study proved that the invasiveness of PA cells is,at least partly,regulated by miRNA-149-dependent expression of ADAM12 and MMP-14. | Zhuo ZHANG Agnes Schäfer Benjamin Voellger Jun-wen WANG Ting LEI Christopher Nimsky Jörg W.Bartsch | 2022 | Current Medical Science2022，42，6： | 0 |
| 8 | Reduced Mythimna separata infestation on Bt corn could benefit aphids显示文摘Use of genetically engineered plants that express insecticidal Cry proteins derived from Bacillus thuringiensis(Bt)have been proven efficacious for managing lepidopteran pests.However,in some cases herbivores that are not targeted by the Bt trait have increased in importance.It has been suggested that reduced caterpillar damage to Bt crops could lead to decreased levels of induced plant defensive compounds which might benefit other non-target herbivores.Here we investigated the potential effect of reduced damage by larvae of Mythimna separata on aphid populations in Bt corn.We compared the performance of Rhopalosiphum maidis feeding on non-Bt corn plants that had been infested by M.separata larvae or were uninfested.The results showed that caterpillar-infested corn plants significantly reduced the fitness of R.maidis leading to a prolonged nymphal development time,reduced adult longevity and fecundity compared to uninfested plants.Consequently,the population growth rate of corn aphids feeding on caterpillar-infested corn plants was significantly lower than on uninfested plants.As expected,the aphids performed significantly better on Lepidoptera-resistant Bt corn than on non-Bt corn when plants were infested with M.separata,since the caterpillars caused very little damage to the Bt plants.The current findings indicate that reduced M.separata infestation could benefit aphid development in Bt corn.Bt corn has the potential to be commercialized in China in the near future and aphids and other non-target pests should be monitored in the farming fields. | Xiang-Wen Li Li-Xiao Du Lei Zhang Yu-Fa Peng Hong-Xia Hua Jörg Romeis Yun-He Li | 2021 | Insect Science2021，28，4： | 0 |
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