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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus显示文摘 | Riad A Unger D Du J | 2007 | Eur J Pharmacol2007，554，1： | 1 |
| 4 | Absorptive clearance of carbamazeping and selected metabolites in rabbit intesine 显示文摘 | Riad L E Sawchuk R J | 1991 | Pharm Res1991，8，： | 1 |
| 5 | Predic- ting evacuation in two major disasters: risk percep- tion, social Influence, and access to resources显示文摘 | RIAD J K NORRIS F H RUBACK R B | 1999 | Journal of Applied Social Psychology1999，29，5： | 1 |
| 6 | Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus 显示文摘 | Riad A Unger D Du J | 2007 | Eur J Pharmacol2007，，1： | 1 |
| 7 | Low-dose treatment with atorvasta- tin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus 显示文摘 | Riad A Du J Stiehl S | 2007 | Eur Pharmacol2007，569，3： | 1 |
| 8 | Toll - like receptor-4 modulates sunqval by induction of left ventlieular remxte- ling after myocalxlial infalxztion in mice显示文摘 | Alexander Riad Sebastian J? get Meike Sobirey | 2008 | The Journal of lmnmnolo- gy2008，180，10： | 1 |
| 9 | Reliability of pe- diobarographs for paediatric foot deformity 显示文摘 | RIAD J COLEMAN S HENLEY J | 2007 | J Child Or- thop2007，1，5： | 1 |
| 10 | Perforation-mediated modified atmosphere packaging of sweet corn显示文摘 | G Riad J K Brecht | 2002 | Proc Fla State HortSoc2002，115，： | 1 |
| 11 | Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus显示文摘 | RIAD A DU J STIEHL S WESTERMANN D | 2007 | Eur J Pharmacol2007，569，3： | 1 |
| 12 | Rainfall-runoff model using an artificial neural network approach 显示文摘 | Riad S Mania J | 2004 | Mathematical and Computer Modelling2004，，40： | 1 |
| 13 | Sofosbuvir plus ribavirin in the treatment of chronic HCV genotype 4 infection in patients of Egyptian ancestry显示文摘 | Ruane P J Ain D Riad J | 2013 | Hepatology2013，58，1： | 1 |
| 14 | Chronic inhibition of p38MAPK improves cardiac and endothelial function in experimental diabetes mellitus显示文摘 | Riad A Unger D Du J | 2007 | Eur J Pharmacol2007，554，1： | 1 |
| 15 | Perforation-mediated modified atmosphere packaging of sweet corn 显示文摘 | RIAD G S BRECHT J K CHAU K V | 2002 | Proc Fla State Hort Soc2002，115，： | 1 |
| 16 | Low-dose treatment with atorvas- tatin leads to anti-oxidative and anti-inflammatory effects in di- abetes mellitus 显示文摘 | Riad A Du J Stiehl S | 2007 | Eur J Pharmacol2007，569，3： | 1 |
| 17 | Low - dose treatment with atorvastatin leads to anti - oxidative and anti - inflammatory effects in diabetes mellitus 显示文摘 | Riad A Du J Stiehl S | 2007 | Eur J Pharmacol2007，569，3： | 1 |
| 18 | Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus 显示文摘 | Riad A Du J Stiehl S | 2007 | Eur J Pharmacol2007，569，3： | 1 |
| 19 | Perforation-mediated modified atmospherepackaging of sweet corn显示文摘 | RIAD G BRECHT J K | 2002 | Proceedings of the Florida StateHorticultural Society2002，115，： | 1 |
| 20 | Chronic inhibition of p38MAPK improves cardiac and endothelial function in ex- perimental diabetes mellitus 显示文摘 | Riad A Unger D Du J | 2007 | Eur J Pharmacol2007，554，1： | 1 |
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