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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Single-stage DC-AC Converter for photovoltaic systems显示文摘 | Ribeiro H Pinto A Borges B | 2010 | IEEE Energy Conversion Congress and Exposition2010，，： | 1 |
| 3 | Resource sha- ring optimization for device-to-device communication underlaying cellular networks显示文摘 | Yu C H Doppler K Ribeiro C B | 2011 | IEEE Transactions on Wireless Communications2011，10，8： | 1 |
| 4 | Intestinal barrier function and weight gain in malnourished children taking glutamine supplemented enteral formula显示文摘 | LIMA A A BRITO L F RIBEIRO H B | 2005 | J Pediatr Gastroenterol Nutr2005，40，： | 1 |
| 5 | Sorafenib in combination with capecitabine: an oral regimen for patients with HER2-negative locally advanced or metastatic breast cancer 显示文摘 | Baselga J Segalla JG Roch6 H Del Giglio A Pinczowski H Ciruelos EM Filho SC G6mez P Van Eyll B Bermejo B Llombart A Garicochea B Durdn Md Hoff PM Espi6 M de Moraes AA Ribeiro RA Mathias C Gil Gil M Ojeda B Morales J Kwon Ro S Li S Costa F | 2012 | J Clin Oncol2012，30，13： | 1 |
| 6 | Image complexity and feature extraction for steganalysis of LSB matching steganography显示文摘 | LIU Qingzhong SUNG A H RIBEIRO B WEI Mingzhen CHEN Zhongxue XU Jiangyun | 2008 | International Journal of Information Sciences2008，，178： | 1 |
| 7 | Image complexity and feature mining for steganalysis of least significant bit matching steganography 显示文摘 | Liu Q Z Sung A H Ribeiro B etal | 2008 | Information Sciences2008，178，1： | 1 |
| 8 | A brief survey of Web data extraction tools 显示文摘 | LAENDER A H F RIBEIRO - NETO B A | 2002 | SIG2MOD Record2002，31，2： | 1 |
| 9 | Optical integration of a real-valued function by measurement of a stokes parameter 显示文摘 | Lemos G B Ribeiro P H Walborn S P | 2014 | Journal of the Optical Society of America A2014，31，4： | 1 |
| 10 | Re- moval of Cu,Pb and Zn in an applied electric field in calcare- ous and non-calcareous soils显示文摘 | OTTOSEN L M HANSEN H K RIBEIRO A B | 2001 | Journal of Hazardous Materi- als2001，85，3： | 1 |
| 11 | Image complexity and feature mining for steganalysis of least significant bit matching steganography显示文摘 | LIU Q SUNG A H RIBEIRO B | 2008 | Information Sciences2008，178，1： | 1 |
| 12 | Heuristically accelerated multi agent reinforcement learning显示文摘 | REINALDO A C B MARTINS M F RIBEIRO C H C | 2014 | IEEE Transactions on Cybernetics2014，44，2： | 1 |
| 13 | Reactions of neopentane, methylcyclohexane, and 3,3-dimethylpentane on tungsten carbides : The effect of surface oxygen on reaction pathways显示文摘 | RIBEIRO F H DALLA B R A BOUDART M | 1991 | J Catal1991，130，1： | 1 |
| 14 | Evaluation of viability of Aspergillus Flavus and aflatoxins degradation in irradiated samples of maize显示文摘 | Aquino S Ferreira F Ribeiro D H B Corréa B Greiner R Villavicencio A L C H | 2005 | Brazilian Journal of Microbiology2005，36，： | 1 |
| 15 | Resource sharing optimization for device-to-device communication underlaying cellular networks显示文摘 | YU C H DOPPLER K RIBEIRO C B | 2011 | IEEE Transactions on Wireless Communications2011，10，8： | 1 |
| 16 | Resource Sha- ring Optimization for Device- to- Device Communication Underlaying Cellular Networks 显示文摘 | YU C H Doppler K Ribeiro C B | 2011 | Wireless Communica- tions IEEE Transactions on2011，10，8： | 1 |
| 17 | Structure and reactivity of PdOx/ZrO2 catalysts for methane oxidation at low temperatures 显示文摘 | Fujimoto K Ribeiro F H Miguel A B | 1998 | Journal of Catalysis1998，179，： | 1 |
| 18 | Tripalmitin and monoacylglycemls as modifiers in the crys- taUisation of palm oil显示文摘 | BASSO R C RIBEIRO A P B MASUCHI M H | 2010 | Food Chem2010，122，4： | 1 |
| 19 | Preparation of nanodispersions containing β- carotene by solvent displacement method 显示文摘 | Ribeiro H S Chu B S Ichikawa S | 2008 | Food Hydrocolloids2008，22，： | 1 |
| 20 | Resource sharing op- timization for device-to-device communication underlaying cellular networks 显示文摘 | YU C H DOPPLER K RIBEIRO C B | 2011 | IEEE Transactions on Wireless Communications2011，10，8： | 1 |
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