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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Physical activity in primary and secondary prevention of cardiovascular disease:Overview updated显示文摘Although the observed progress in the cardiovascular disease treatment, the incidence of new and recurrent coronary artery disease remains elevated and constitutes the leading cause of death in the developed countries. Three-quarters of deaths due to cardiovascular diseases could be prevented with adequate changes in lifestyle, including increased daily physical activity. New evidence confirms that there is an inverse dose-response relationship between physical activity and cardiovascular disease and mortality risk. However, participation in moderate to vigorous physical activity may not fully attenuate the independent effect of sedentary activities on increased risk for cardiovascular diseases. Physical activity also plays an important role in secondary prevention of cardiovascular diseases by reducing the impact of the disease, slowing its progress and preventing recurrence. Nonetheless, most of eligible cardiovascular patients still do not benefit from secondary prevention/cardiac rehabilitation programs. The present review draws attention to the importance of physical activity in the primary and secondary prevention of cardiovascular diseases. It also addresses the mechanisms by which physical activity and regular exercise can improve cardiovascular health and reduce the burden of the disease. | Alberto J Alves Joao L Viana Suiane L Cavalcante Nórton L Oliveira JoséA Duarte Jorge Mota JoséOliveira Fernando Ribeiro | 2016 | World Journal of Cardiology2016，8，10： | 6 |
| 3 | Solvent recovery from soybean oil/hexane mis- celia by polymeric membranes 显示文摘 | RIBEIRO A P B DE MOUR J M L N GONCALVES L A G | 2006 | Journal of Membrane Science2006，282，12： | 1 |
| 4 | Comparative effects of salinity and water stress on photosynthesis, water relations and growth of Jatropha curcas plant 显示文摘 | SILVA E N RIBEIRO R V FERREIRA-SILVA S L VIEGAS R A SILVEIRA J A G | 2010 | Journal of Arid Environment2010，74，10： | 1 |
| 5 | An applied database system forthe optimization of cutting conditions and tool selection显示文摘 | Ribeiro M V Coppini N L | 1999 | Journal of Materials Processing Technology1999，92，： | 1 |
| 6 | Intratumor genomie heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases 显示文摘 | Torres L Ribeiro FR Pandis N | 2007 | Breast Cancer Res Treat2007，102，2： | 1 |
| 7 | Asymptomatic dogs are highly competent to transmit Leishmania ( Leishmania ) infantum chagasi to the natural vector显示文摘 | Márcia Dalastra Laurenti Claudio Nazaretian Rossi Vania Lúcia Ribeiro da Matta Thaise Yumie Tomokane Carlos Eduardo Pereira Corbett Nágila Francinete Costa Secundino Paulo Filemon Paulocci Pimenta Mary Marcondes | 2013 | Veterinary Parasitology2013，，： | 1 |
| 8 | Hydrogen production by aqueous-phase reforming of glycerol over nickel catalysts supported on CeO2显示文摘 | Manfro R L Costa A F Ribeiro N F P | | 0，，： | 1 |
| 9 | Aqueous-phase reforming of glycerol using Ni-Cu catalysts prepared from hydrotalcite-like precursors显示文摘 | Manfro R L Pires T P M D Ribeiro N F P | | 0，，： | 1 |
| 10 | Fault tolerant reversible AC motor drive system 显示文摘 | Jacobina C B de Araujo Ribeiro R L Lima A M N | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
| 11 | Production of renewable hydrogen by aqueous-phase reforming of glycerol over Ni-Cu catalysts derived from hydrotalcite precursors显示文摘 | Tuza P V Manfro R L Ribeiro N F P | | 0，，： | 1 |
| 12 | Lagrangean relaxation with clusters for point-feature cartographic label placement problems显示文摘 | Ribeiro G M Lorena L A N | 2008 | Computers & Operations Research2008，35，7： | 1 |
| 13 | A new mathematical model and a Lagrangean decomposition for the point-feature cartographic label placement problem显示文摘 | Mauri G R Ribeiro G M Lorena L A N | 2010 | Computers & Operations Research2010，37，12： | 1 |
| 14 | Fault-tolerant reversible AC motor drive system显示文摘 | Jacobina C B Ribeiro R L A Lima A M N | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
| 15 | Dense and porous titanium substrates with a biomimetic calcium phosphate coating显示文摘 | RIBEIRO A A BALESTRA R M ROCHA M N PERIPOLLI S B ANDRADE M C PEREIRA L C OLIVEIRA M V | 2013 | Appl Surf Sci2013，265，： | 1 |
| 16 | Success factors for environmentally sustainable product innovation:A systematic literature review显示文摘 | Medeiros J F D Ribeiro J L D Cortimiglia M N | 2013 | Journal of Cleaner Production2013，65，15： | 1 |
| 17 | Synthesis of La1-xSrxMnO3 powders by polymerizable complex method: evalua- tion of structural, morphological and electrical properties 显示文摘 | Conceigao L Ribeiro N F P Souza M M V M | 2011 | Ceramics International2011，37，7： | 1 |
| 18 | Salt stress induced damages on the photosynthesis of physic nut young plants显示文摘 | Silva E N D Ribeiro R V Silva S L F | 2011 | Scientia Agricola2011，68，1： | 1 |
| 19 | Influence of perceived value on purchasing decisions of green products in Brazil显示文摘 | MEDEIROS J F D RIBEIRO J L D CORTIMIGLIA M N | 2016 | Journal of Cleaner Production2016，110，： | 1 |
| 20 | An applied database system for the optimiza- tion of cutting conditions and tool selection显示文摘 | Ribeiro M V Coppini N L | 2002 | Journal of Materials Pro- cessing Technology2002，9293，： | 1 |
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