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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 3 | Simultane- ous on - line pre - concentration and determination of trace metals in environmental samples by flow injection combined with inductively coupled plasma mass spectrom- etry using silica gel modified with niobium (Ⅴ) oxide 显示文摘 | Mahez H F Vieira M A Ribeiro A S | 2008 | Talanta2008，74，： | 1 |
| 4 | X-ray photoelectron spectroscopy of amorphous AlN alloys prepared by reactive rf sputtering显示文摘 | RIBEIRO C T M ZANATTA A R ALVAREZ F | 2002 | Journal of Non-Crystalline Solids2002，，1： | 1 |
| 5 | Optical spectroscopy of Er^3+ and Yb^3+ co-doped fluoroindate glasses显示文摘 | RIBEIRO C T M ZANATTA A R NUNES L A O | 1998 | J Appl Phys1998，83，4： | 1 |
| 6 | Difficulties Encountered by Farmers in the Implementation of Traceability Bovine显示文摘 | Lopes M A Demeu A A Ribeiro A D B | 2012 | Arquivo Brasileiro De Medicina Veterinaria E Zootecnia2012，64，6： | 1 |
| 7 | Conventional and microwave induced pyrolysis of coffee hulls for the production of hydrogen rich fuel gas显示文摘 | DOMINGUEZ A MENENDEZ J A FERNANDEZ Y PIS J J VALENTE NABAIS JM CARROTT J M RIBEIRO CARROTT M M L | | 0，，1： | 1 |
| 8 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 9 | Off-label drug prescribing in a Portuguese paediatric emergency unit显示文摘 | Ribeiro M Jorge A Macedo AF | 2013 | Int J Clin Pharm2013，35，1： | 1 |
| 10 | Enthalpies of combustion, vapour pressures, and enthalpies of sublimation of 8- hydroxyquinoline, 5-nitro-8-hydroxyquinoline, and 2-methyl-8-hydroxyquinoline显示文摘 | Ribeiro Da Silva M A V Monte M J S Matos M A R | 1989 | Chem Thermodyn1989，，21： | 1 |
| 11 | Solvent recovery from soybean oil/hexane mis- celia by polymeric membranes 显示文摘 | RIBEIRO A P B DE MOUR J M L N GONCALVES L A G | 2006 | Journal of Membrane Science2006，282，12： | 1 |
| 12 | Generalized mixture operators using weighting functions:a comparative study with WA and OWA显示文摘 | RIBEIRO R A PEREIRA R A M | 2003 | European Journal of Operational Research2003，，145： | 1 |
| 13 | Electric and morphologic properties of SnO2 films prepared by modified sol-gel process显示文摘 | Dal Santos M A Antunas A C Ribeiro C | 2003 | Materials Letters2003，57，28： | 1 |
| 14 | Assessment of genetic damage induced by dental bleaching agents on mouse lymphoma cells by single cell gel (comet) assay显示文摘 | Ribeiro D A Marques M E Salvadori D M | 2005 | J Oral Rehabil2005，32，10： | 1 |
| 15 | A review of vibration-based structural health monitoring with special emphasis on composite materials 显示文摘 | Montalv-o D Maia N M M Ribeiro A M R | 2006 | Shock and Vibration Digest2006，38，4： | 1 |
| 16 | Ad- sorption of H2, CO2, CH4, CO, N2 and H20 in activa- ted carbon and zeolite for hydrogen production显示文摘 | LOPES F V S GRANDE C A RIBEIRO A M | 2009 | Sep- aration Science and Technology2009，，5： | 1 |
| 17 | The transmissibility concept in multiple degrees of freedom systems 显示文摘 | Maia N M M Silva J M M Ribeiro A M R | 2001 | Mechanical Systems and Signal Processing2001，15，1： | 1 |
| 18 | Influence of the Sulphurization Time on the Morphological, Chemical, Structural and Electrical Properties of Cu2 ZnSnS4 Polyerystalline Thin Films 显示文摘 | Gonzalez J C Fernandes P A Ribeiro G M | 2014 | Solar Energy Materials and Solar Cells2014，123，： | 1 |
| 19 | Multi-electrode recordings: the next steps显示文摘 | Nicolelis M A Ribeiro S | 2002 | Curr Opin Neurobiol2002，12，5： | 1 |
| 20 | Removal of organic contaminants from soils by an electrokinetic process:the case of atrazine显示文摘 | RIBEIRO A B RODRIGUEZ-MAROTO J M MATEUS E P | 2005 | Chemosphere2005，59，： | 1 |
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