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| 1 | Modeling sarcomagenesis using multipotent mesenchymal stem cells显示文摘因为他们的唯一的性质,间充质的干细胞(MSC ) 代表最有希望的成年干细胞之一在临床的应用的一个宽数组全球正在被使用的 multipotent。总的来说,引人注目的证据支持前 vivo 的长期的安全扩展了人的 MSC,它不似乎自发地转变。然而,试验性的数据表明在 MSC 和癌症之间的一个连接,和 MSC 被报导了禁止或支持肿瘤生长取决于还未定义的条件。有趣地,稳固的证据为某些肉瘤基于转基因的老鼠和 MSC 的基因干预把这些房间放作为起源的最可能的房间。这个研究区域逐渐地正在被探索开发 sarcomagenesis 的精确基于 MSC 的模型,它将在关于间充质的癌症的病原学和致病提供更好的理解无疑是珍贵的,最后导致更特定的治疗的发展对开始肉瘤的房间指导了。不幸地,仍然,很少对位于 MSC 转变下面的机制被知道,进一步的研究被要求基于人的 MSC 开发真正的肉瘤模型。这里,我们包括地考察存在肉瘤的基于 MSC 的模型并且讨论导致 MSC 和 sarcomagenesis 的 tumoral 转变的最普通的机制。 | Rene Rodriguez Ruth Rubio Pablo Menendez | 2012 | Cell Research2012，22，1： | 8 |
| 2 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 3 | 考虑街区尺寸的不同交通方式广义出行成本分析显示文摘我国的城市规划理念逐渐从封闭小区转向开放街区,以实现街区内部道路公共化,优化路网布局.但不同街区模式对城市交通的具体影响缺乏定量研究.为此,本文区分街区内外部出行,分析了街区尺寸对城市路网交通性能(出行距离、时间及转弯次数)的影响,并基于出行时间和费用,构建了各种交通方式广义出行成本,分析其在不同街区尺寸下的变化特征.结果表明,给定路网规模下,街区尺寸越大,平均内部出行时间占比越高,越不利于公共交通出行,例如当街区尺寸为600 m时,公共交通方式下的平均内部出行时间占比高于私家车10%.未来城市规划需更多地考虑街区尺寸的影响. | 张凌煊 MONICA Menendez 张士行 帅斌 | 2019 | 交通运输系统工程与信息2019，19，2： | 5 |
| 4 | 明显增强的镧掺杂锶铁氧体的磁光克尔效应显示文摘采用陶瓷法制备了稀土La^(3+)掺杂的锶铁氧体Sr_(1-x)La_xFe_(12)O_(19)(x=0,0.05,0.10,0.15,0.20)。系统地研究了La^(3+)取代对材料结构、磁性能的影响,特别是对磁光克尔效应的影响。实验结果表明,La^(3+)取代Sr^(2+)能显著增强锶铁氧体的磁光克尔效应,当x=0.20时,与SrFe_(12)O_(19)相比,磁光克尔效应增加到了1%。 | 朱德如 刘先松 胡锋 JOSE Luis Menendez | 2012 | 材料研究学报2012，26，1： | 3 |
| 5 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 6 | Ex vivo antioxidant effects of D-004, a lipid extract from Roystonea regia fruits, on rat prostate tissue显示文摘瞄准:调查是否有 D-004 的口头的处理,古巴的皇室成员的一篇类脂化合物摘录把水果藏在掌内,在正常和睾丸激素(T) 的前列腺织物生产抗氧化剂效果对待的老鼠。方法:在我们的第一个实验,正常老鼠被散布进五个组:与车辆对待的一个组和与 D-004 (100, 200, 400 或 800 mg/kg ) 对待的四个组。在我们的第二个实验,老鼠被使随机化进五个组:一个否定控制组和四个注射 T 的组。后者由与与 D-004 (200, 400 或 800 mg/kg ) 对待的车辆,和三个组对待的一个积极控制组组成。结果:在正常老鼠, D-004 (100-800 mg/kg ) 显著地并且 dose-dependently 禁止了开始铁的 malondialdehyde (MDA ) 在前列腺 homogenates (35.7%-80.0%) 对控制的累积。分别地, D-004 (200-800 mg/kg ) 显著地在正常老鼠的前列腺 homogenates 把基线 MDA 和羰基组归结为约 80% 和 50%(100%) 在对待 T 的老鼠。结论:有 D-004 的口头的处理在正常、注射 T 的老鼠 dose-dependently 并且显著地减少了 MDA 和羰基组。这些调查结果证明在有效的剂量给阻止前列腺增生的 D-004 也在前列腺织物生产抗氧化剂效果。 | Yohani Perez Vivian Molina Rosa Mas Roberto Menendez Rosa M. Gonzailez Ambar Oyarzabal Sonia Jimenez | 2008 | Asian Journal of Andrology2008，10，4： | 2 |
| 7 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 8 | 炼钢渣和炭的混合物用于微波辅助甲烷干气重整反应(英文)显示文摘The use of steel-making slag as catalysts for microwave-assisted dry reforming of CH4 was studied. Two carbon materials (an activated carbon and a metallurgical coke), mixtures of the carbon materials and Fe-rich slag, and mixtures of the carbon materials and Ni/Al2O3 were tested as catalysts. The mixtures of slag with carbons gave rise to higher and steadier conversions than those achieved over the carbon materials alone. In addition, the use of the metallurgical coke mixed with metal-rich catalysts gave rise to remarkable results. Thus, no CH4 and CO2 conversions were achieved when coke was used alone, whereas high conversions were obtained when it was mixed with the metal-rich catalysts. | Jose M. BERMUDEZ Beatriz FIDALGO Ana ARENILLAS J. Angel MENENDEZ | 2012 | 催化学报2012，33，7： | 2 |
| 9 | Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes显示文摘Interleukin-15(IL-15)is a pro-inflammatory cytokine that is required for the survival and activation of memory CD8^(+)T cells,natural killer(NK)cells,innate lymphoid cells,macrophages and dendritic cells.IL-15 is implicated in the pathogenesis of various autoimmune diseases such as rheumatoid arthritis,inflammatory bowel disease,psoriasis and autoimmune type 1 diabetes(T1D).IL-15 receptor(IL-15R)consists of a specificαchain,theβchain that is shared with IL-2R and the commonγchain.IL-15 is unique in the manner in which it binds and signals through its receptor subunits.IL-15 that is complexed with IL-15Rαbinds to theβγreceptor complex present on the responding cell to mediate its biological effects through a process referred to as trans-presentation.The trans-presented IL-15 is essential to mediate the biological effects on T lymphocytes and NK cells.Here we show that IL-15,but not IL-15Rα,is required for the development of spontaneous and virus-induced T1D,viral clearance and for antigen cross-presentation to CD8^(+)T lymphocytes.Our findings provide insight into the complexities of IL-15 signalling in the initiation and maintenance of CD8^(+)T cell-mediated immune responses. | Diwakar Bobbala Marian Mayhue Alfredo Menendez Subburaj Ilangumaran Sheela Ramanathan | 2017 | Cellular & Molecular Immunology2017，14，7： | 2 |
| 10 | Regulation of the p14ARF promoter by DNA methylation 显示文摘 | Badal V Menendez S Coomber D | 2008 | Cell Cycle2008，7，1： | 1 |
| 11 | A novel CYR61-triggered CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ ERK2 MAPK signaling pathway 显示文摘 | Menendez JA Vellon L Mehmi I | 2005 | Oncogene2005，24，5： | 1 |
| 12 | Getting the interactions right: Will higher O3 levels interfere with induced defenses to aphid feeding? 显示文摘 | Menendez A I Romero A M Folcia A M | 2008 | Basic and Applied Ecology2008，10，3： | 1 |
| 13 | Heregulin-triggered Her-2/neu signaling enhances nuclear accumulation of p21WAF1/CIP1 and protects breast cancer cells from cisplatin-induced genotoxic damage显示文摘 | Menendez JA Mehmi I Lupu R | 2005 | Int J Oncol2005，26，3： | 1 |
| 14 | Unusually high selectivity to C2+ alcohols on bimetallic CoFe catalysts during CO hydrogenation显示文摘 | De la PENA OSHEA V A MENENDEZ N N TORNERO J D FIERRO J L G | 2003 | Catal Lett2003，88，34： | 1 |
| 15 | Localized mediastinal lymph node hyperplasia resembling thymoma 显示文摘 | Castleman B Iverson 1 Menendez VP | 1956 | Cancer1956，9，4： | 1 |
| 16 | Metformin and the ATM DNA damage response ( DDR ) : accelerating the onset of stress-induced senescence to boost protection against cancer 显示文摘 | Menendez JA Cuff S Oliveras-Ferraros C | 2011 | Aging( Albany NY)2011，3，11： | 1 |
| 17 | Conventional and microwave induced pyrolysis of coffee hulls for the production of hydrogen rich fuel gas显示文摘 | DOMINGUEZ A MENENDEZ J A FERNANDEZ Y PIS J J VALENTE NABAIS JM CARROTT J M RIBEIRO CARROTT M M L | | 0，，1： | 1 |
| 18 | Localized mediasstinal lymph nodehyperplasia resembling thymoma显示文摘 | Castleman B Iverson L Menendez VP | 1956 | Cancer1956，9，： | 1 |
| 19 | Aberrant miR -182 expression promotes melanoma metastasis by repressingF0X03 and microphthalmia -associated transcription factor 显示文摘 | Segura M F Hanniford D Menendez S | 2009 | Pnatl Acad Sci2009，106，6： | 1 |
| 20 | Inhibition of orthotopic human b ladder tumor growth by lentiviral gene transfer of endostatin显示文摘 | Kikuchi E Menendez S Bochner BH | 2004 | Clin Cancer Res2004，10，5： | 1 |
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