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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | High body mass index predicts multiple prostate cancer lymph node metastases after radical prostatectomy and extended pelvic lymph node dissection显示文摘Our aim is to evaluate the association between body mass index(BMI)and preoperative total testosterone(TT)levels with the risk of single and multiple metastatic lymph node invasion(LNI)in prostate cancer patients undergoing radical prostatectomy and extended pelvic lymph node dissection.Preoperative BMI,basal levels of TT,and prostate-specific antigen(PSA)were evaluated in 361 consecutive patients undergoing radical prostatectomy with extended pelvic lymph node dissection between 2014 and 2017・Patients were grouped into either nonmetastatic,one,or more than one metastatic lymph node invasion groups.The association among clinical factors and LNI was evaluated.LNI was detected in 52(14.4%)patients:28(7.8%)cases had one metastatic node and 24(6.6%)had more than one metastatic node.In the overall study population,BMI correlated inversely with TT(r=-0.256;P<0.0001).In patients without metastases,BMI inversely correlated with TT(r=-0.282;P<0.0001).In patients with metastasis,this correlation was lost.In the overall study population,BMI(odds ratio[OR]=1.268;P=0.005)was the only in dependent clinical factor associated with the risk of multiple metastatic LNI compared to cases with one metastatic node.In the nonmetastatic group,TT was lower in patients with BMI>28 kg m^2(P<0.0001).In patients with any LNI,this association was lost(P=0.232).The median number of positive nodes was higher in patients with BMI>28 kg m^2(P-0.048).In our study,overweight and obese patients had a higher risk of harboring multiple prostate cancer lymph node metastases and lower TT levels when compared to patients with normal BMI. | Antonio B Porcaro Alessandro Tafuri Marco Sebben Tania Processali Marco Pirozzi Nelia Amigoni Riccardo Rizzetto Aliasger Shakir Maria Angela Cerruto Matteo Brunelli Salvatore Siracusano Walter Artibani | 2020 | Asian Journal of Andrology2020，22，3： | 3 |
| 3 | A simple role for BDNF in learning and memory?显示文摘 | Carla Cunha Riccardo B Kerrie LT | 2010 | Molecular neurosci2010，2，： | 1 |
| 4 | Effect of substrate grain size and surface treatments on the cutting properties of diamond coated co-cemented tungsten carbide tools显示文摘 | Riccardo P Fabio B Fabrizio C | 2002 | Diamond and Related Materials2002，11，： | 1 |
| 5 | Laparoscopically assisted vaginal hysterectomy versus total abdominal hysterectomy: a prospective,randomized, muhieenter study 显示文摘 | Riccardo M Mauro B Errico Z | 1999 | Am J Obstet Gynecol1999，180，2： | 1 |
| 6 | Chronic fatigue显示文摘 | B Riccardo | 2006 | CMAJ2006，175，4： | 1 |
| 7 | Vibration control of a flexible space manipulator during on orbit operations 显示文摘 | MARCO S PAOLO G RICCARDO M GIOVANNI B P | 2012 | Acta Astronautica2012，73，2： | 1 |
| 8 | Thrombus aspiration before primary angioplasty improves myocardial reperfusion in acute myocardial infarction 显示文摘 | PEDRO SO PAOLA C RICCARDO B | 2006 | JACC2006，8，48： | 1 |
| 9 | 显示文摘 | Giovanni L Giuseppe B Riccardo C | 2003 | Biomaterials2003，24，： | 1 |
| 10 | Efficacy of Caspofungin Addition to Trimethoprim-Sulfamethoxazole Treatment for Severe Pneumocystis Pneumonia in Solid Organ Transplant Recipients显示文摘 | Riccardo U Emanuele DM Cristina B | 2007 | Transplantation2007，84，： | 1 |
| 11 | Muhifunctional nano- beads based on quantum dots and magnetic nanoparticles: synthe- sis and cancer cell targeting and sorting 显示文摘 | Riccardo D C Nadja C B Andrea R | | ACS Nano0，，： | 1 |
| 12 | Financial Systen' s Across Developed Economic: Convergence or Path Dependence? 显示文摘 | MAGADA B AANDREA G RICCARDO M | 1997 | Research in Economics1997，，1： | 1 |
| 13 | Amisulpride in the short-term treatment of depressive and phsical symptoms in cancer patients during chemothrapies 显示文摘 | Riccardo T Carlotta B Luca B | 2007 | Supportive Care in Cancer2007，15，5： | 1 |
| 14 | Selection, character- ization and comparison of β-glucosidase from mould and yeasts em- ployable for cnological application显示文摘 | RICCARDO N B GIOVANNI S ROSA P | 2004 | Enzyme and Microbial Technology2004，350，： | 1 |
| 15 | Evolving problems to learn about particle swarm and other optimizers显示文摘 | Langdon W B Riccardo P | 2007 | IEEE Transactions on Evolutionary Computation2007，11，5： | 1 |
| 16 | Analytical formulation for local buckling and post buckling analysis of stiffened laminated panels 显示文摘 | Chiara B Riccardo V | 2008 | Thin Walled Structures2008，47，3： | 1 |
| 17 | Laparoscopically assisted vaginal hysterectomy versus total obdominal hysterectomy;a prospective,randomized,multicenter study显示文摘 | Riccardo M Mauro B Errico Z | 1999 | Am J Obstet Gynecol1999，180，2： | 1 |
| 18 | Engine misfire monitoring for a V12 engine by exhaust pressure analysis显示文摘 | MASSIMO C CORRADO R RICCARDO B | 1998 | SAE1998，，5： | 1 |
| 19 | Particle swarm optimization an overview显示文摘 | Riccardo P James K Tim B | 2007 | Swarm Intell2007，1，： | 1 |
| 20 | Trust and partner selection in social networks: an experimentally grounded model 显示文摘 | Giangiacomo B Flaminio S Riccardo B | 2012 | Social Networks2012，，34： | 1 |
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