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| 1 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 2 | Recommendations for Comprehensive Stroke Centers: A Consensus Statement From the Brain Attack Coalition显示文摘 | Mark J. Alberts Richard E. Latchaw Warren R. Selman Timothy Shephard Mark N. Hadley Lawrence M. Brass Walter Koroshetz John R. Marler John Booss Richard D. Zorowitz Janet B. Croft Ellen Magnis Diane Mulligan Andrew Jagoda Robert O’Connor C Michael Cawley | 2005 | Stroke2005，，7： | 2 |
| 3 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 4 | Visual Interactive Simulation-Histroy,Recent Developments and Major Issues显示文摘 | Robert M O'Keefe | 1987 | Simulation1987，49，3： | 1 |
| 5 | Shape Distribution显示文摘 | Robert O Thomas F Bernard C | 2002 | ACM Transactions on Graphics2002，21，4： | 1 |
| 6 | Identification of molecular markers for the decetion of the yellow rust resistance gene Yr17 in wheat显示文摘 | Robert O Abelard C Dedryver F | 1999 | Molecular Breeding1999，，5： | 1 |
| 7 | Increased levels of microparticles originating from endothelial cells, platelets and erythrocytes in subjects with metabolic syndrome : relationship with oxidative stress 显示文摘 | Helal O Dcfoort C Robert S | 2011 | Nutr Metab Cardiovasc Dis2011，21，： | 1 |
| 8 | Estrogen receptor-[alpha] signaling in osteoblast progenitors stimulates cortical bone accrual显示文摘 | Almeida Maria Iyer Srividhya Martin-Millan Marta Bartell Shoshana M Han Li Ambrogini Elena Onal Melda Xiong Jinhu Weinstein Robert S Jilka Robert L O’Brien Charles A Manolagas Stavros C | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 9 | Olanzapin and acute urinary retention in two geriatric patients显示文摘 | Randi C Kirsten MW Robert O | 2007 | The Am- erican Journal of Geriatric Pharmacotherapy2007，5，3： | 1 |
| 10 | Intestinal intraepithelial lymphocytes bind to colon cancer cells by HML-1and CD11a显示文摘 | Roberts A I O’Connell S M and Ebert E C | 1993 | Cancer Res1993，53，7： | 1 |
| 11 | Wheat leaf rust uredospore production and carbon and nitrogen export in relation to lesion size and density显示文摘 | Robert C Bancal M O Lannou C | 2002 | Phytopathology2002，92，： | 1 |
| 12 | Wheat leaf rust uredospore production on adult plants: Influence of leaf nitrogen content and Septoria tritici blotch 显示文摘 | Robert C Bancal M O Lannou C | 2004 | Phytopathology2004，94，7： | 1 |
| 13 | SPARC represses E- eadherin and induces mesenchymal transition during melanoma development 显示文摘 | Robert G Gaggioli C Ballet O | 2006 | Cancer Res2006，66，15： | 1 |
| 14 | Safety and tumor responses with lambrolizumab (anti-PD-1) in melano- ma显示文摘 | Hamid O Robert C Daud A | 2013 | N Engl J Med2013，369，2： | 1 |
| 15 | Mechanism relating cambial electrical resistance to periodic growth rate of balsam fir显示文摘 | Robert O B Waiter C S Weston D | 1983 | Canadian Journal of Forestry Research1983，，13： | 1 |
| 16 | Safety and tumor responses with lambrolizumab ( anti-PD-1 ) in melanoma 显示文摘 | Hamid O Robert C Daud A | 2013 | N Engl J Med2013，369，2： | 1 |
| 17 | Portfolio based assess- ments in medical education: are they valid and reliable for sum- mative purposes 显示文摘 | Roberts C Newble DI O' Rourke AJ | 2002 | Med Educ2002，36，： | 1 |
| 18 | A survey of structure-property relationships of surfaces that resist the adsorption of protein显示文摘 | Emanuele O Robert G C Shuichi T | 2001 | Langmuir2001，17，： | 1 |
| 19 | Measuring Organizational Communication显示文摘 | ROBERT K H O'REILLY C A | 1974 | Journal of Applied Psychology1974，，59： | 1 |
| 20 | Identification of molecular markers for the detection of the yellow rust resistance gene Yrl7 in wheat显示文摘 | Robert O Abelard C Dedryver F | 1999 | Molecular Breeding1999，5，2： | 1 |
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