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| 1 | Modeling cardiac arrest and resuscitation in the domestic pig显示文摘Cardiac arrest remains a leading cause of death and permanent disability worldwide. Although many victims are initially resuscitated, they often succumb to the extensive ischemia-reperfusion injury inflicted on the internal organs, especially the brain. Cardiac arrest initiates a complex cellular injury cascade encompassing reactive oxygen and nitrogen species, Ca2+ overload, ATP depletion, pro- and anti-apoptotic proteins, mitochondrial dysfunction, and neuronal glutamate excitotoxity, which injures and kills cells, compromises function of internal organs and ignites a destructive systemic inflammatory response. The sheer complexity and scope of this cascade challenges the development of experimental models of and effective treatments for cardiac arrest. Many experimental animal preparations have been developed to decipher the mechanisms of damage to vital internal organs following cardiac arrest and cardiopulmonary resuscitation(CPR), and to develop treatments to interrupt the lethal injury cascades. Porcine models of cardiac arrest and resuscitation offer several important advantages over other species, and outcomes in this large animal are readily translated to the clinical setting. This review summarizes porcine cardiac arrest-CPR models reported in the literature, describes clinically relevant phenomena observed during cardiac arrest and resuscitation in pigs, and discusses numerous methodological considerations in modeling cardiac arrest/CPR. Collectively, published reports show the domestic pig to be a suitable large animal model of cardiac arrest which is responsive to CPR, defibrillatory countershocks and medications, and yields extensive information to foster advances in clinical treatment of cardiac arrest. | Brandon H Cherry Anh Q Nguyen Roger A Hollrah Albert H Olivencia-Yurvati Robert T Mallet | 2015 | World Journal of Critical Care Medicine2015，4，1： | 2 |
| 2 | Stability constrained optimal power flow显示文摘 | Gan D Q Robert J T Zimmerman R D | 2000 | IEEE Trans on Power Systems2000，15，2： | 1 |
| 3 | Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis 显示文摘 | PADMAVATHY S N DAVID C L ROBERT Q T | 1995 | Molecular and Cellular Biology1995，15，5： | 1 |
| 4 | Potas-sium nutrition effects on Lint Yield and Fiber Quali-ber of Acalacotton显示文摘 | Cassman K Q Kerby T A Roberts B A | 1990 | Crop Science1990，30，： | 1 |
| 5 | Risk management framework for BOT power projects in China显示文摘 | WANG S Q ROBERT L K T TING S K | 1999 | Journal of Project Finance1999，4，4： | 1 |
| 6 | Reduction of the Gangli oside Binding Activity of the Tetanus Toxin HC Fragment Destroys Immunogenicity: Implications for Development of Nove Tetanus Vaccines显示文摘 | Omar Q Dorothea S Robert T | 2006 | Infection and Immunity2006，74，8： | 1 |
| 7 | Zirconates as New Materials for Thermal Barrier Coatings 显示文摘 | Robert V Cao X Q Frank T | 2000 | Journal of American Ceramic Society2000，83，8： | 1 |
| 8 | The evolution of the type I interferons显示文摘 | Roberts R Liu L M Guo Q T | 1998 | J Interferon Cytokine Res1998，18，10： | 1 |
| 9 | New insight into the measurement of short fiber content 显示文摘 | Cui X Calamari T A Jr Robert K Q | 2000 | Proceedings of the Belt- wide Cotton Production Conference2000，，2： | 1 |
| 10 | Potassium nutrition effects on lint yield and fiber quality of Acala cotton显示文摘 | CASSMAN K Q KERBY T A ROBERTS B A BRYANT D C BROUDER S M | 1990 | Crop Science1990，30，： | 1 |
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