|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of vitamin B_(12) on methylmalonyl-CoA mutase activity显示文摘Vitamin B 12 is an organometallic compound with important metabolic derivatives that act as cofactors of certain enzymes,which have been grouped into three subfamilies depending on their cofactors.Among them,methylmalonyl-CoA mutase (MCM) has been extensively studied.This enzyme catalyzes the reversible isomerization of L-methylmalonyl-CoA to succinyl-CoA using adenosylcobalamin (AdoCbl) as a cofactor participating in the generation of radicals that allow isomerization of the substrate.The crystal structure of MCM determined in Propionibacterium freudenreichii var.shermanii has helped to elucidate the role of this cofactor AdoCbl in the reaction to specify the mechanism by which radicals are generated from the coenzyme and to clarify the interactions between the enzyme,coenzyme,and substrate.The existence of human methylmalonic acidemia (MMA) due to the presence of mutations in MCM shows the importance of its role in metabolism.The recent crystallization of the human MCM has shown that despite being similar to the bacterial protein,there are significant differences in the structural organization of the two proteins.Recent studies have identified the involvement of an accessory protein called MMAA,which interacts with MCM to prevent MCM's inactivation or acts as a chaperone to promote regeneration of inactivated enzyme.The interdisciplinary studies using this protein as a model in different organisms have helped to elucidate the mechanism of action of this isomerase,the impact of mutations at a functional level and their repercussion in the development and progression of MMA in humans.It is still necessary to study the mechanisms involved in more detail using new methods. | Tóshiko TAKAHASHI-IIGUEZ Enrique GARCíA-HERNANDEZ Roberto ARREGUíN-ESPINOSA María Elena FLORES | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，6： | 3 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Targeted next‐generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas显示文摘 | Eliana Amato Marco dal Molin Andrea Mafficini Jun Yu Giuseppe Malleo Borislav Rusev Matteo Fassan Davide Antonello Yoshihiko Sadakari Paola Castelli Giuseppe Zamboni Anirban Maitra Roberto Salvia Ralph H Hruban Claudio Bassi Paola Capelli Rita T Lawlor Mi | 2014 | J. Pathol2014，，3： | 2 |
| 4 | High frequency ozone generation system显示文摘 | Roberto D Daniel M Fidela T | 2001 | Ozone Science & Engineering2001，23，2： | 2 |
| 5 | Bolted Steel Connections: Tests on T Stub Components 显示文摘 | James A S Roberto T L | 2000 | Journal of Structural Engineering2000，，1： | 1 |
| 6 | Epidermal growth factor induced intracellular Ca2+ oscillations in microvascular endothelial cells显示文摘 | Francesco M Roberto B Simona T | 2003 | J Cell Physiol2003，194，2： | 1 |
| 7 | DNA and RNA binding properties of an arginine-based ' Extended Chiral Box' Peptide Nucleic Acid显示文摘 | Alessandro C Tullia T Roberto C | | 0，，02： | 1 |
| 8 | Food analysis and food authentication by peptide nucleic acidPNA)-based technologies显示文摘 | Stefano S Roberto C Tullia T | | 0，，01： | 1 |
| 9 | Plant-microorganism-soil interactions influence the Fe availability in the rhizosphere of cucumber plants 显示文摘 | Youry P Alexander P Roberto T | 2015 | Plant Physiology and Biochemistry2015，87，： | 1 |
| 10 | Body fat and insulin resist- ance independently predict increased serum C-reactive protein in hyperandrogenic women with polycystic ovary syndrome 显示文摘 | Flavia T Romolo D Roberto C | 2009 | Eur J Endocrinol2009，161，5： | 1 |
| 11 | DTG combustion behaviour of charcoals 显示文摘 | Roberto T Marilena G Paolo G | 1987 | Fuel1987，66，12： | 1 |
| 12 | Bolted Steel Connections:Tests on T-stub components显示文摘 | James A S Roberto T L | 2000 | Journal of Structural Engineering2000，2000，： | 1 |
| 13 | Using weather ensemble predic- tions in electricity demand forecasting 显示文摘 | James W T Roberto B | 2003 | International Journal of Forecasting2003，，19： | 1 |
| 14 | Rigorous analysis of the GIEM cell显示文摘 | ROBERTO DE LEO T ROZZI | 1991 | IEEE Trans EMC1991，39，3： | 1 |
| 15 | Bolted Steel Connectio ns: Tests on T-stub components 显示文摘 | JAMES A Swanson ROBERTO T Leon | 2000 | Journal of Structural Engineering2000，126，1： | 1 |
| 16 | Obtaining CeO2-ZrO2 mixed oxides by coprecipitation:role of preparation conditions显示文摘 | Sonia L Claudio A T Roberto R A | 2005 | Applied Catalysis B:Environmental2005，58，34： | 1 |
| 17 | Safety and efficacy of endo-scopic colonic stenting as a bridge to surgery in the managementof intestinal obstruction due to left colon and rectal cancer: A sys-tematic review and meta-analysis 显示文摘 | Roberto C Eriberto Stefano T | 2013 | Eur J Surg Oncol2013，22，1： | 1 |
| 18 | Experimen- tal characterization of FRP composite-wood pile structural re- sponse by bending tests显示文摘 | ROBERTO L A ANTONIS P MICHAEL T C | 2003 | Marine Structures2003，16，： | 1 |
| 19 | Direct analysis for design evaluation of partially restrained steel framing systems显示文摘 | ANDREA E S DONALD W W ROBERTO T L | 2005 | Journal of Structural Engineering ASCE2005，131，9： | 1 |
| 20 | Inhibitory Action of Aqueous Coffee Ground Extracts on the Corrosion of Carbon Steel in HCl Solution显示文摘 | VANESSA V T ROBERTO S A CAMILA F de S | | 0，，07： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员