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| 1 | RTOG 0211:a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients显示文摘PURPOSE: To determine the safety and efficacy of gefitinib,an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor,in combination with radiation for newly diagnosed glioblastoma(GBM) patients.METHODS AND MATERIALS: Between March 21,2002,and May 3,2004,Radiation Therapy Oncology Group(RTOG) 0211 enrolled 31 and 147GBM patients in the phase 1 and 2 arms,respectively.Treatment consisted of daily oral gefinitnib started at the time of conventional cranial radiation therapy(RT) and continued post RT for 18 months or until progression.Tissue microarrays from 68 cases were analyzed for EGFR expression.RESULTS: The maximum tolerated dose(MTD) of gefitinib was determined to be 500 mg in patients on non-enzyme-inducing anticonvulsant drugs(non-EIAEDs).All patients in the phase 2 component were treated at a gefitinib dose of 500 mg;patients receiving EIADSs could be escalated to 750 mg.The most common side effects of gefitinib in combination with radiation were dermatologic and gastrointestinal.Median survival was 11.5 months for patients treated per protocol.There was no overall survival benefit for patients treated with gefitinib + RT when compared with a historical cohort of patients treated with RT alone,matched by RTOG recursive partitioning analysis(RPA) class distribution.Younger age was significantly associated with better outcome.Per protocol stratification,EGFR expression was not found to be of prognostic value for gefitinib + RT-treated patients.CONCLUSIONS: The addition of gefitinib to RT is well tolerated.Median survival of RTOG 0211 patients treated with RT with concurrent and adjuvant gefitinib was similar to that in a historical control cohort treated with radiation alone. | Chakravarti A Wang M Robins HI Lautenschlaeger T Curran WJ Brachman DG Schultz CJ Choucair A Dolled-Filhart M Christiansen J Gustavson M Molinaro A Mischel P Dicker AP Bredel M Mehta M | 2013 | 中国神经肿瘤杂志2013，11，1： | 8 |
| 2 | Precision atomic gravimeter based on Bragg diffraction显示文摘 | P A Altin M T Johnsson V Negnevitsky G R Dennis R P Anderson J E Debs S S Szigeti K S Hardman S Bennetts G D McDonald L D Turner J D Close N P Robins | 2013 | New Journal of Physics2013，，2： | 2 |
| 3 | Maximum likelihood from incomplete data via the EM algorithm显示文摘 | Dempster A P Laird N M Robin D B | 1977 | Journal of the Royal Statistical Society1977，39，1： | 1 |
| 4 | Predicting the flexural loaddeflection response of steel fibre reinforced concrete from strain, crack-width,fibre pull-out and distribution data 显示文摘 | Jones P A Austin S A Robins P J | 2008 | Materialsand Structures2008，41，3： | 1 |
| 5 | The effect of international institutional factors on properties of accounting eamings显示文摘 | Ball R Kotharis P Robin A | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
| 6 | The flow around a surface-mounted cube in uniform and turbulent streams显示文摘 | CASTRO I P ROBINS A G | 1977 | J Fluid Mech1977，79，2： | 1 |
| 7 | Turning, compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | E1 Kader N A Robin P Paillat J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 8 | Comparison of the behavior of manufactured and other airborne nanoparticles and the consequences for prioritising research and regulation activities 显示文摘 | KUMAR P FENNELL P ROBINS A | 2010 | Journal of Nanoparticle Research2010，12，： | 1 |
| 9 | The effect of international institutional factors on properties of accounting earnings显示文摘 | Ball R Kothari S P Robin A | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
| 10 | The role of GDH in plant nitrogen metabolism 显示文摘 | Robin S A Slade A P Phillips R | 1991 | Plant Physiol1991，95，： | 1 |
| 11 | A per oxiredoxin antioxidant is encoded by a dormancy related gene,Perl , expressed during late development in the aleu rone and embryo of barley grains显示文摘 | Robin A P Stacy Else Munthe Terie Steinum | 1996 | Plant Molecular Biology1996，31，： | 1 |
| 12 | Numerical considerations for simulations of flow and dispersion around buildings显示文摘 | COWAN I R CASTRO I P ROBINS A G | 1997 | Journal of Wind Engineering and Industrial Aerodynamics1997，67，8： | 1 |
| 13 | The Effect of International Institutional Factors on Properties of Accounting Earnings 显示文摘 | Ball R Kothari S P Robin A | 2000 | Journal of accounting and economics2000，29，1： | 1 |
| 14 | The Effect of International Institutional Factors on Properties of Accounting Earnings 显示文摘 | R Ball S P Kothari A Robin | 2000 | Journal of Accounting and Economics2000，29，： | 1 |
| 15 | The effect of international institutional factors on properties of accounting earnings 显示文摘 | Ball R Kothari S P Robin A | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
| 16 | Turning,compacting and the addition of water as factors affecting gaseous emissions in farm manure composting显示文摘 | EL KADER N A ROBIN P PAILLAT J M | 2007 | Bioresource Technology2007，98，14： | 1 |
| 17 | Molecularpaleohydrology: Interpreting the hydrogen isotopiccomposition of lipid biomarkers from photosynthesizing organisms 显示文摘 | Sachse D Billault I Bowen G Y Chikaraishi Y Dawson T E Feakins S J Freeman K H Magill C R McInerney F A vander Meer M T J Polissar P Robins R J Sachs J P Schmidt HL Sessions A L White J W C West J B Kahmen A | 2012 | Ann Rev Earth Planet Sci2012，40，： | 1 |
| 18 | The Effect of International Institutional Factors on Properties of Accounting Earnings显示文摘 | Kothari S P Robin A | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
| 19 | EIS study of Ti-23Ta alloy in artificial saliva显示文摘 | ROBIN A MERIRELIS J P | 2009 | Corrosion Engineering Science and Technology2009，44，5： | 1 |
| 20 | The Effect of International Institutional Factors on Properties of Accounting Earnings 显示文摘 | Ball R S P Kothari and A Robin | 2000 | Journal of Accounting and Economics2000，29，1： | 1 |
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