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| 1 | Research advances on the multiple uses of Moringa oleifera: a sustainable alternative for socially neglected population显示文摘Moringa oleifera Lam(Moringaceae) is a plant with high nutritional and medicinal value. Native to India, it is now widely distributed throughout tropical and subtropical regions of the world. Its different parts are sources of proteins, vitamins and minerals and present different pharmacological and biotechnological potential. Moreover, M. oleifera seeds are widely used in water and effluent treatment, for their coagulation, flocculation and sedimentation properties, their ability of improving water quality, by reducing organic matter and microbial load, with special applicability in intensive animal production systems, such as aquaculture. In addition, due to its high nutritional value and several medicinal properties, this tree may act as a nutritional and medical alternative for socially neglected populations. In this context, this review gathers information on M. oleifera, emphasizing its chemical constituents, nutritional, pharmacological and antimicrobial properties, applications in the treatment of water effluents, and ecological and social aspects. | Raimunda Samia Nogueira Brilhante Jamille Alencar Sales Vandbergue Santos Pereira Débora de Souza Collares Maia Castelo-Branco Rossana de Aguiar Cordeiro Célia Maria de Souza Sampaio Manoel de Araújo Neto Paiva Joao Bosco Feitosa dos Santos JoséJúlio CostaSidrim Marcos Fábio Gadelha Rocha | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，7： | 10 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | Mesa-Perez J M Cortez L A B Rocha J D | 2005 | Fuel Processing Technology2005，86，5： | 1 |
| 4 | Replication of the tumor necrosis factor receptor-associated factor 1/complement component 5 region as a susceptibility locus for rheumatoid arthritis in a European family-based study显示文摘 | Kurreeman F A S Rocha D Houwing-Duistermaat J | 2008 | Arthritis &Rheumatism2008，58，9： | 1 |
| 5 | Unidimensional heat transfer analysis of elephant grass and sugar cane bagasse slow pyrolysis in a fixed bed reactor显示文摘 | L A B Cortez J D Rocha | 2005 | Fuel Processing Technology2005，86，： | 1 |
| 6 | A comparison of proper orthngonal decomposition and Mote Carlo simulation of wind pressure data显示文摘 | Rocha M M Cabral S V S Riera J D | 2000 | Journal of Wind Engineering Industrial Aerodynamics2000，84，： | 1 |
| 7 | A comparison of proper orthogonal decomposition and Monte Carlo simulation of wind pressure显示文摘 | M M Rocha S VS Cabral J D Riera | 2000 | Wind Englnd Aerodyn2000，84，： | 1 |
| 8 | Regulation of NF- kappaB and p53 through activation of ATR and Chkl by the ARF tumour suppressor 显示文摘 | Rocha S Garrett M D Campbell K J | 2005 | EMBO J2005，24，6： | 1 |
| 9 | Isotopic evidence for variations in the marine calcium cycle over the Cenozoic显示文摘 | De La Rocha C L DePaolo D J | 2000 | Science2000，289，： | 1 |
| 10 | Luminesc-ent multifunctional lanthanides-based metal-organic frameworks显示文摘 | Rocha J Carlos L D Paz F A A | 2011 | Chem Soc Rev2011，40，2： | 1 |
| 11 | High envi- ronmental temperature and humidity decrease oocyte quality in Bos taurus but not in Bos indicus cows显示文摘 | Rocha A Randel R D Broussard J R | 1998 | Theriogenology1998，49，3： | 1 |
| 12 | Automatic fruit and vegetable classification from images 显示文摘 | ROCHA A HAUAGGE D C WAINER J | 2010 | Computers and Electronics in Agriculture2010，70，1： | 1 |
| 13 | IL-1β and IL-1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis显示文摘 | Queiroz D M Guerra J B Rocha G A | 2004 | Gastroenterology2004，127，1： | 1 |
| 14 | Biomass briquetting and its perspectives in Brazil显示文摘 | Felfli F F Mesa P J M Rocha J D | 2011 | Biomass and Bioenergy2011，35，1： | 1 |
| 15 | Isotopic evidence for variations in the marine calcium cycle over the Cenozoic显示文摘 | De La Rocha C L DePaolo D J | 2000 | Science2000，289，： | 1 |
| 16 | Hydropyrolysis: a versatile technique for solid fuel liquefaction, sulphur speciation and biomarker release 显示文摘 | ROCHA J D BROWN S D LOVE G D | 1997 | J Analy Appl Pyroly1997，40，41： | 1 |
| 17 | Biologicalactivities of sulfated polysaccharides from tropical seaweeds显示文摘 | Costa L S Fidelis G P Cordeiro S L R M Oliveira D A Sabry R B G CSmara L T D B Nobre MSS PCosta J Almeida-Lima E H C Farias E L Leite H A 0 Rocha | 2010 | Biomedicine & Pharmacotherapy2010，64，1： | 1 |
| 18 | Hydropyrolysis: a versatile technique for solid fuel liquefaction, sulphur speciation and biomarker release显示文摘 | Rocha J D Brown S D Love G D | 1997 | Journal of Analyti- cal and Applied Pyrolysis1997，40，41： | 1 |
| 19 | A comparison of proper orthogonal decomposition and Monte Carlo simulation of wind pressure显示文摘 | Rocha M M Cabral S V S Riera J D | 2000 | J Wind Eng Ind Aerodyn2000，84，3： | 1 |
| 20 | Mechanisms involved in the gastroprotective activity of esculin on acute gastric lesions in mice显示文摘 | Rios ER Rocha NF Ven(a)ncio ET Moura BA Feitosa ML Cerqueira GS Soares PM Woods D J de Sousa FC Leal LK Fonteles MM | | 0，，1： | 1 |
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