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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling显示文摘 | Benedito R Rocha SF Woeste M | 2012 | Nature2012，484，： | 1 |
| 3 | Pro- moters in Heterogeneous Catalysis : The Role of CI on Ethy- lene Epoxidation overAg 显示文摘 | Rocha T C R Haevecker M Knop-Gericke A | 2014 | J Catal2014，312，： | 1 |
| 4 | Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling显示文摘 | Benedito R Rocha SF Woeste M | | 0，，7392： | 1 |
| 5 | An environmen- tally friendly flow-based procedure with photo-in- duced oxidation for the spectrophotometric determi- nation of chloride in urine and waters 显示文摘 | Rocha Diogo L Rocha Fdbio R P | 2013 | Micro- chemical Journal2013，108，： | 1 |
| 6 | Immobilization of commercial laccase on spent grain显示文摘 | da Silva A M Tavare A P M Rocha C M R | 2012 | Process Biochem2012，479，7： | 1 |
| 7 | Effect of dental surface treatment with Nd:YAG and Er:YAG lasers on bond strength of resin composite to recently bleached enamel显示文摘 | Rocha Gomes Torres C Caneppele TM Del Moral de Lazari R | 2012 | Laser Med Sci2012，27，4： | 1 |
| 8 | Acute generalized, widespread bleeding, diagnosis and management显示文摘 | ROCHA E PARAMO J A MONTES R | 1998 | Haematologica1998，83，： | 1 |
| 9 | Aldosterone target organ protection by eplerenone显示文摘 | Rudolph AE Rocha R McMahon EG | 2004 | Mol Cell Endocrinol2004，217，12： | 1 |
| 10 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 11 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 12 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 13 | Epigallocatechin gallate- loaded polysaccharide nanoparticles for prostate cancer chemoprevent- ion 显示文摘 | Rocha S Generalov R Pereira Mdo C | 2011 | Nanomedicine2011，，： | 1 |
| 14 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 15 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 16 | Rationale for the use of aldosterone antagonists in congestive heart failure显示文摘 | ROCHA R WILLIAMS GH | 2002 | Drugs2002，62，5： | 1 |
| 17 | Rationale for the use of aldosterone antagonists in congestive heart failure 显示文摘 | Rocha R Williams GH | 2002 | Drugs2002，62，： | 1 |
| 18 | Differentially expressed angiogenic genes in diabetic erectile tissue-results from a microarray screening显示文摘 | CASTELA A SOARES R ROCHA F | 2012 | Mol Genet Metab2012，105，2： | 1 |
| 19 | Continuous venovenous hemodiafiltration in patients with multiple organ dysfunction syndrome in an intensive care unit显示文摘 | Abdo AA Castellanos R Rocha M | 2012 | MEDICC Rev2012，14，3： | 1 |
| 20 | Fucan inhibits Chinese ham- ster ovarycell (CHO) adhesion to fibronectin by binding to the extracellular matrix 显示文摘 | ROCHA H FRANCO C R | 2005 | Planta Med2005，71，： | 1 |
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