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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 3 | Molecular differenc- es between hydrocarbon and fluorocarbon surfaetants at the COJ water interface 显示文摘 | Stone M T Da Rocha S R P Rossky P J | 2003 | Journal of Physics Chemistry2003，107，10： | 1 |
| 4 | Preparation and characterization of affinity magnetoliposomes useful for the detection of antiphospholipid antibodies显示文摘 | ROCHA F M DE PINDO S C ZOLLERATION R L | 2001 | J Magn Magn Mater2001，225，12： | 1 |
| 5 | Epigallocatechin gallate- loaded polysaccharide nanoparticles for prostate cancer chemoprevent- ion 显示文摘 | Rocha S Generalov R Pereira Mdo C | 2011 | Nanomedicine2011，，： | 1 |
| 6 | Anticancer, antichemotactic and antimicrobial activities of marine sponges collected off the coast of Santa Catarina, southern Brazil显示文摘 | Noel R Monks Clea Lerner Amélia T Henriques Fabiane M Farias Elfrides E.S Schapoval Edna S Suyenaga Adriana B da Rocha Gilberto Schwartsmann Beatriz Mothes | 2002 | Journal of Experimental Marine Biology and Ecology2002，，1： | 1 |
| 7 | Oil sludge treatment by photocatalysis applying black and white light显示文摘 | ROCHA O R S DANTAS R F DUARTE M M M B | 2010 | Chemical Engineering Journal2010，157，1： | 1 |
| 8 | The use of software product lines for business process management:a systematic literature review显示文摘 | ROCHA R S FANTINATO M | 2013 | Information and Software Technology2013，55，8： | 1 |
| 9 | Working area, safe- ty zones, and angles of approach for posterior C1 lateral mass screw placement: a quantitative anatomical and morphometric evaluation显示文摘 | Rocha R Safavi-Abbasi S Reis C | 2007 | J Neurosurg Spine2007，6，3： | 1 |
| 10 | Needs of nursing guidance for self-care of clients on hemodialysis therapy 显示文摘 | Dos S I Rocha R P Berardinelli L M | 2011 | Rev Bras Enferm2011，64，2： | 1 |
| 11 | Chloroplast-localized protein kinases:A step forward towards a complete inventory显示文摘 | BAYER R G STAEL S ROCHA A G | 2012 | Journal of Experimental Botany2012，63，4： | 1 |
| 12 | Water in car- bon dioxide macroemulsions and miniemulsions with a hydrocar- bon surfactant显示文摘 | Johnston K P Cho Dongman Da Rocha S R P | 2001 | Langmuir2001，17，23： | 1 |
| 13 | Wet depositionand related atmospheric chemistry in the S(a)o Paulo Metropolis,Brazil:Part 1-Major inorganic ions in rainwater as evaluated by capillary electrophoresis with contactless conductivity detection显示文摘 | F R Rocha S Fracassi A José | 2003 | Atmos Environ2003，37，： | 1 |
| 14 | Sediment-contact fishembryo toxicity assay with Danio rerio to assess particle-boundpollutants in the Tiete River Basin(Sao Paulo,Brazil)显示文摘 | Rocha P S Bernecker C Strecker R | 2011 | Ecotoxicology and Environmental Safety2011，74，7： | 1 |
| 15 | 查看详情显示文摘 | Rocha R A Muccillo E N S | | 0，，1： | 1 |
| 16 | Emission quantum yield of europium (Ⅲ) mixed complexes with thenoyhriiluoroacetonate and some aromatic ligands 显示文摘 | Silva F R G E Menezes J F S Rocha G B Rocha G B Alves S Brito H F Longo R L Malta O L | 2000 | Journal of Alloys and Compounds2000，303，304： | 1 |
| 17 | Constructive heuristic algorithm for the DC model in network transmission expansion planning 显示文摘 | Romero R Rocha C Mantovani J R S | 2005 | IEE Proceedings of Generation Transmission and Pistribution2005，152，2： | 1 |
| 18 | Is myeloperox?idase a key component in the GSH-PX-induced vascular damage related to nephropathy in type 2 diabetes?显示文摘 | Hovira-Llopis S Rocha M Falcon R | 2013 | Antioxid Redox Signal2013，，： | 1 |
| 19 | Use of rice straw as biosorbent for removal of Cu(Ⅱ),Zn(Ⅱ),Cd(Ⅱ) and Hg(Ⅱ)ion in industrial effluents显示文摘 | ROCHA C G ZAIA D A M ALFAYA R V D S | | 0，，： | 1 |
| 20 | Notch-dependent VEGFR3 up- regulation allows angiogenesis without VEGF-VEGFR2 signalling显示文摘 | Benedito R Rocha S F Woeste M Zamykal M Radtke F Casanovas O | 2012 | Nature2012，484，： | 1 |
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