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| 1 | Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years. | Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer | 2014 | World Journal of Gastroenterology2014，20，7： | 5 |
| 2 | The Effect of Cannabidiol and URB597 on Conditioned Gaping(a Model of Nausea)Elicited by a Lithium-Paired Context in the Rat显示文摘 | Rock E M Limebeer C L Mechoulam R | 2008 | Psychopharmacology (Berl)2008，196，3： | 1 |
| 3 | Repcatplateletpheresis: the effects on the donor and the yield 显示文摘 | Rock G Tittley P Sternbach M | 1992 | Vox Sang1992，63，5： | 1 |
| 4 | Dividend Policy Under Asymmetric Information显示文摘 | Miller M H Rock K | 1985 | Journal of Finance1985，，40： | 1 |
| 5 | Surhee-eom- plex films of guanidine on tantalum nitride electrochemically characterized for application in chemical mechanical planariza- tion 显示文摘 | ROCK S E CRAIN D J PETTIT C M | 2012 | Thin Solid Films2012，520，7： | 1 |
| 6 | Commonage Land and Farmer Up- take of the Rural Environment Protection Scheme in Ireland 显示文摘 | Van Rensburg T M Murphy E Rocks P | 2009 | Land Use Policy2009，26，2： | 1 |
| 7 | The contribution of platelets in the production of cryoprecipitates for use in a fibrin glue 显示文摘 | Rock G Neurath D Lu M | 2006 | Vox Sang2006，91，3： | 1 |
| 8 | Geochemistry, mineralogy and petrology of a new find of ultramafic lamprophyres from bull- jah Pool, nabberu Basin, Yilgarn Craton, Western Australia 显示文摘 | Hamilton R Rock N M S | 1990 | Lithos1990，24，： | 1 |
| 9 | Outlier detection in the multiple cluster setting using the minimum covariance determinant estimator显示文摘 | HARDIN J ROCKED M | 2004 | Computational Statistics and Data Analysis2004，44，： | 1 |
| 10 | A compariaon of different ligation methods on friction显示文摘 | Hain M Dhopatkar A Rock P | 2006 | Am J Orhtod Dentofacial Orthop2006，130，5： | 1 |
| 11 | Trends in mortality from coronary heart and cerebrovascular diseases in the Americas: 1970-2000显示文摘 | Rock iguez T Malvezzi M Chatenoud L | 2006 | Heart2006，92，4： | 1 |
| 12 | Age-and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans ptgressiva 显示文摘 | Rocke DM Zasloff M Pper J et at | 1994 | Clinical Orthopaedics and Related Research1994，301，： | 1 |
| 13 | Prevemive managemellt of cerebrosplnal fluid leakage in translagyrinthine surgery显示文摘 | Meyerson L R Monsell E M Rock J R | 1996 | Laryngoscope1996，106，5： | 1 |
| 14 | Geochemical discrimination between shoshonitic and potassic volcanic rocks in different tectonic settings: a pilot study显示文摘 | Muller D Rock N M S Groves D I | 1992 | Mineralogy and Petrology1992，46，： | 1 |
| 15 | The nature and origin of lamprophyres: An overview显示文摘 | ROCK N M S | 1987 | Geol Soc London Spee Pub1987，30，： | 1 |
| 16 | Early salt stress effects on the differential expression of vacuolar H -ATPase genes in roots and leaves of mesembryanthemum erystallinum 显示文摘 | LOW R ROCKED B KRISH M | 1996 | Plant Physiol1996，110，1： | 1 |
| 17 | Is the in vitro antioxidant potential of whole-grain cereals and cereal products well reflected in vivo显示文摘 | Fardet A Rock E Rémésy C | | 0，，02： | 1 |
| 18 | Can lamprophyres resolves the genetic controversy over mesothermal gold deposit? 显示文摘 | Rock N M S Groves D I | 1988 | Geology1988，16，： | 1 |
| 19 | Analysis of the products of cryoprecipi-tation : RiCoF is deficient in cryosupernatant plasma 显示文摘 | FREEDMAN M ROCK G | 2010 | TransfusApher Sci2010，43，2： | 1 |
| 20 | Who drops out of high school and why?Findings from a na tional study显示文摘 | Ekstrom R B Goertz M E Pollack J M Rock DA | 1986 | Teachers College Record1986，，87： | 1 |
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