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| 1 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 2 | Structural organization of the Helieoverpa zea gene encoding the precursor protein for pheromone biosynthesis activating neuropeptide and other neuropeptides 显示文摘 | MA P W K KNIPPLE D C ROELOFS W L | 1994 | Proc Natl Acad Sci USA1994，91，14： | 1 |
| 3 | Enchytraeus crypticus as model species in soil ecotoxicology 显示文摘 | Castro-Ferreira M P Roelofs D van Gestel C A | 2012 | Chemosphere2012，87，11： | 1 |
| 4 | ENA imaging:seeing the invisible显示文摘 | Son Brandt P C Mitchell D G Roelof E C | 2005 | Johns Hopkins APL Technical Digest2005，26，2： | 1 |
| 5 | On the structure of activated hydrotalcites as solid base catalysts for liquid-phase aldol condensation显示文摘 | ROELOFS J C A A LENSVELD D J DILLEN A J JONG K P | 2001 | J Catal2001，203，1： | 1 |
| 6 | Nonsteroidal anti-in- flammatory drugs for low back pain: an updated Coehrane review 显示文摘 | ROELOFS P D DEYO R A KOES B W | 2008 | Spine2008，33，16： | 1 |
| 7 | An Event Horizon Imager(EHI) Mission Concept Utilizing Medium Earth Orbit Sub-mm Interferometry显示文摘Submillimeter interferometry has the potential to image supermassive black holes on event horizon scales,providing tests of the theory of general relativity and increasing our understanding of black hole accretion processes.The Event Horizon Telescope(EHT) performs these observations from the ground,and its main imaging targets are Sagittarius A~* in the Galactic Center and the black hole at the center of the M87 galaxy.However,the EHT is fundamentally limited in its performance by atmospheric effects and sparse terrestrial(u,v)-coverage(Fourier sampling of the image).The scientific interest in quantitative studies of the horizon size and shape of these black holes has motivated studies into using space interferometry which is free of these limitations.Angular resolution considerations and interstellar scattering effects push the desired observing frequency to bands above 500 GHz.This paper presents the requirements for meeting these science goals,describes the concept of interferometry from Polar or Equatorial Medium Earth Orbits(PECMEO) which we dub the Event Horizon Imager(EHI),and utilizes suitable space technology heritage.In this concept,two or three satellites orbit at slightly different orbital radii,resulting in a dense and uniform spiral-shaped(u,v)-coverage over time.The local oscillator signals are shared via an inter-satellite link,and the data streams are correlated on-board before final processing on the ground.Inter-satellite metrology and satellite positioning are extensively employed to facilitate the knowledge of the instrument position vector,and its time derivative.The European space heritage usable for both the front ends and the antenna technology of such an instrument is investigated.Current and future sensors for the required inter-satellite metrology are listed.Intended performance estimates and simulation results are given. | KUDRIASHOV V MARTIN-NEIRA M ROELOFS F FALCKE H BRINKERINK C BARYSHEV A HOGERHEIJDE M YOUNG A POURSHAGHAGHI H KLEIN-WOLT M MOSCIBRODZKA M DAVELAAR J BARAT I DUESMANN B VALENTA V PERDIGUES ARMENGOL J M DE WILDE D MARTIN IGLESIAS P ALAGHA N VAN DER VORST M | 2021 | 空间科学学报2021，41，2： | 0 |
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