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| 1 | Impairment of hepatic stat-3 activation and reduction of PPAR alpha activity in fructose-fed rats显示文摘 | Roglans N Vila L Farre M | 2007 | Hepatology2007，45，： | 1 |
| 2 | Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight显示文摘 | Laguna J C Alegret M Roglans N | 2014 | Nutrients2014，6，12： | 1 |
| 3 | Way back for fructose and liver metabolism:Bench side to molecular insights显示文摘The World Health Organization recommends that the daily intake of added sugars should make up no more than 10% of total energy.The consumption of sugarsweetened beverages is the main source of added sugars.Fructose,together with glucose,as a component of high fructose corn syrups or as a component of the sucrose molecule,is one of the main sweeteners present in this kind of beverages.Data from prospective and intervention studies clearly point to high fructose consumption,mainly in the form of sweetened beverages,as a risk factor for several metabolic diseases in humans.The incidence of hypertension,nonalcoholic fatty liver disease(NAFLD),dyslipidemia(mainly hypertriglyceridemia),insulin resistance,type 2 diabetes mellitus,obesity,and the cluster of many of these pathologies in the form of metabolic syndrome is higher in human population segments that show high intake of fructose.Adolescent and young adults from lowincome families are especially at risk.We recently reviewed evidence from experimental animals and human data that confirms the deleterious effect of fructose on lipid and glucose metabolism.In this present review we update the information generated in the past 2 years about high consumption of fructose-enriched beverages and the occurrence of metabolic disturbances,especially NAFLD,type 2 diabetes mellitus,and metabolic syndrome.We have explored recent data from observational and experimental human studies,as well as experimental data from animal and cell models.Finally,using information generated in our laboratory and others,we provide a view of the molecular mechanisms that may be specifically involved in the development of liver lipid and glucose metabolic alterations after fructose consumption in liquid form. | Alba Rebollo Núria Roglans Marta Alegret Juan C Laguna | 2012 | World Journal of Gastroenterology2012，18，45： | 1 |
| 4 | Bezafibratc induces acyl-CoA oxidase mRNA levels and fatty acid poroxisomal beta-oxidation in rat white adipose tissue显示文摘 | VAZQUEZ M ROGLANS N CABRERO A | 2001 | Mol Cell Biochem2001，216，： | 1 |
| 5 | Fibrate treatment does not modify the expression of acylcoenzyme A oxidase in human liver显示文摘 | Roglans N Bellido A Rodriguez C | 2002 | Clin Pharmacol Ther2002，72，6： | 1 |
| 6 | Impairment of hepatic Stat‐3 activation and reduction of PPARα activity in fructose‐fed rats显示文摘 | Núria Roglans Laia Vilà Mireia Farré Marta Alegret Rosa María Sánchez Manuel Vázquez‐Carrera Juan Carlos Laguna | 2007 | Hepatology2007，，3： | 1 |
| 7 | Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism 显示文摘 | Vila L Roglans N Alegret M | 2008 | Hepatology2008，48，5： | 1 |
| 8 | Suppressor of cytokine signaling-3(SOCS-3) and a deficit of serine/threonine(Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism显示文摘 | Vila L Roglans N Alegret M | 2008 | Hepatology2008，48，： | 1 |
| 9 | Impairment of hepatic Stat-3 activa?tion and reduction of PP ARalpha activity in fructose-fed rats显示文摘 | Roglans N Vila L Farre M | 2007 | Hepa?tology2007，45，： | 1 |
| 10 | Metabolic alterations and in- creased liver mTOR expression precede the development of autoim- mune disease in a murine model of lupus erythematosus 显示文摘 | Vila L Roglans N Baena M | 2012 | PLoS One2012，，： | 1 |
| 11 | Atorvastatin reverses age-related reduction in rat hepatic PPAR and HNF-4显示文摘 | Sanguino E Roglans N Alegret M | 2005 | Br J Pharmacol2005，145，： | 1 |
| 12 | Atorvastatin treatment induced peroxisome prollferator-activated receptor alpha expression and decreased plasma nonesterilied fatty acids and liver triglyceride in fructose-fed rats显示文摘 | Roglans N Sanguino E Peris C | 2002 | J Pharmacol Exp Ther2002，302，1： | 1 |
| 13 | Ageing introduces a complex pattern of changes in several rat brain transcription factors depending on gender and anatomical localization显示文摘 | Sanguino E Roglans N Rodriguez-Calvo R | 2006 | Exp Gerontol2006，41，4： | 1 |
| 14 | Impairment of hepatic stat-3 activation and reduction of PPAR alpha activity in fructose-fed rats显示文摘 | Roglans N Vila L Farre M | 2007 | Hepatology2007，45，： | 1 |
| 15 | PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats显示文摘 | Aina Rodríguez-Vilarrupla Bàrbara Lavi?a Héctor García-Calderó Lucia Russo Eugenio Rosado Núria Roglans Jaume Bosch Joan Carles García-Pagán | 2012 | Journal of Hepatology2012，，5： | 1 |
| 16 | Fibrates modify the expression of key factors involved in bile-acid synthesis and biliar- y-lipid secretion in gallstone patients 显示文摘 | Roglans N Vazquez-Carrera M Alegret M | 2004 | Ear J Clin Pharmacol2004，59，12： | 1 |
| 17 | Atorvastat in treatment induced peroxisome pro-Liferator activated receptor expression and decreased plasma non-esterified fatty acids and liver triglyceride in fructose2fed rats显示文摘 | ROGLANS N | | 0，，： | 1 |
| 18 | Liquid Fructose Downregulates Liver Insulin Receptor Substrate 2 and Gluconeogenic Enzymes By Modifying Nutrient Sensing Factors In Rats显示文摘 | Alba Rebollo Núria Roglans Miguel Baena Anna Padrosa Rosa M. Sánchez Manuel Merlos Marta Alegret Juan C. Laguna | 2013 | The Journal of Nutritional Biochemistry2013，，： | 1 |
| 19 | Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients显示文摘 | Roglans N Vazquez-Carrera M Alegret M | 2004 | Eur J Clin Pharmacol2004，59，12： | 1 |
| 20 | Suppressor of cytokine signaling-3 (SOCS-3) and a deficit of serine/threonine (Ser/Thr) phosphoproteins involved in leptin transduction mediate the effect of fructose on rat liver lipid metabolism 显示文摘 | Vila L Roglans N Megret M | 2008 | Hepatology2008，48，5： | 1 |
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