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| 1 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 2 | Posterior vitreous detachment induced by microplasmin显示文摘 | Gandorfer A Rohleder M Sethi C | | 0，，02： | 1 |
| 3 | A proposal for standardization in forensic canine DNA typing: allele nomenclature of six canine-specific STR loci 显示文摘 | Hellmann AP Rohleder U Eichmann C Pfeiffer I Parson W Schleenbecker U | 2006 | Journal of Forensic Science2006，51，： | 1 |
| 4 | Salivary alpha amylase as marker for adrenergic activity during stress: effect of be- tablockade 显示文摘 | Van Stegeren A Rohleder N Everaerd W | 2006 | Psychoneuroendocrinology2006，31，1： | 1 |
| 5 | Epiretinal pathology of diffuse diabetic macular edema associated with vitreomacular traction显示文摘 | Arnd Gandorfer Matthias Rohleder Sabine Grosselfinger Christos Haritoglou Michael Ulbig Anselm Kampik | 2005 | American Journal of Ophthalmology2005，，4： | 1 |
| 6 | Determinants of the diurnal course of salivary alpha-amylase 显示文摘 | Nater U M Rohleder N Schlotz W Ehlert U Kir- schbaum C | 2007 | Psyehoneuroendoerinol- ogy2007，32，5： | 1 |
| 7 | Biologi- cal cost of caring for a cancer patient : dysregulation of pro-and antiinflammatory signaling pathways 显示文摘 | Rohleder N Matin T T Ma R Miller G E | 2009 | J Clin Oncol2009，27，5： | 1 |
| 8 | Posterior vitreous detachment induced by microplasmin 显示文摘 | Gandorfer A Rohleder M Sethi C | 2004 | Invest Ophthalmol Vis Sci2004，45，2： | 1 |
| 9 | Epiretinal pathology of vit- reomacular traction syndrome 显示文摘 | Gandorfer A Rohleder M Kampik A | 2002 | Br J Ophthalmol2002，85，8： | 1 |
| 10 | Acute stress respon- ses in salivary alpha-amylase predict increases of plasma norepineph- rine显示文摘 | Thoma MV Kirschbaum C Wolf JM Rohleder N | 2012 | Biol Psychol2012，91，： | 1 |
| 11 | Determinants of salivary α- amylase in humans and methodological considerations 显示文摘 | ROHLEDER N NATER U M | 2009 | Psychoneuroendocrinology2009，34，4： | 1 |
| 12 | Human salivary alpha-amylase reactivity in a psychosocial stress paradigm显示文摘 | Nater UM Rohleder N Gaab J Berger S Jud A Kirschbanm C Ehlert U | 2005 | Int J Psychophysiol2005，55，： | 1 |
| 13 | Neuroendocrine and Psychometric Evaluation of a Placebo Version of the 'Trier Social Stress Test'显示文摘 | HET S ROHLEDER N SCHOOF D | | 0，，07： | 1 |
| 14 | Determinants of salivary alpha - amylase in hu- mans and methodological considerations 显示文摘 | Rohleder N Nater UM | 2009 | Psychoneuroendocrinology2009，34，4： | 1 |
| 15 | The psychosocial stress - induced increase in salivary alpha - amylase is independent of saliva flow rate 显示文摘 | Rohleder N Wolf JM Maldonado EF | 2006 | Psychophysiology2006，43，6： | 1 |
| 16 | Salivary alpha-amylase as a non-invasive biomarker for the sympathetic nervous system : current state of research 显示文摘 | NATER U M ROHLEDER N | 2009 | Psychoneuroendocrinology2009，34，： | 1 |
| 17 | The psychosocial stress-induced increase in salivary alpha amylase is independent of sa- liva flow rate 显示文摘 | Rohleder N Wolf JM Maldonado EF Kirschbaum C | 2006 | Psychophysiology2006，43，： | 1 |
| 18 | Clinical depression and reg- ulation of the inflammatory response during acute stress显示文摘 | Miller G E Rohleder N Stetler C | 2005 | Psycho- somatic Medicine2005，67，5： | 1 |
| 19 | Human salivary alpha-amylase reactivity in a psychosocial stress paradigm 显示文摘 | NATER U M ROHLEDER N GAAB J | 2005 | Int J Psychophysiol2005，55，3： | 1 |
| 20 | Psyehosocial stress-induced activation of salivary alpha-amylase : an indicator of sympathetic activity显示文摘 | Rohleder N Nater UM Wolf JM Ehlert U Kirschbaum C | 2004 | Ann N Y Acad Sci2004，1032，： | 1 |
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