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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Usefulness of ω-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: A double-blind, randomized, placebo-controlled study显示文摘AIM: To assess the value of long-chain ω-3 fatty acids (FAs) supplementation in addition to amino-salicylic-acid (5-ASA) in pediatric patients with Crohn's disease (CD).METHODS: Thirty-eight patients (20 males and 18females, mean age 10.13 years, range 5-16 years)with CD in remission were randomized into two groups and treated for 12 mo. Group Ⅰ (18 patients) received 5-ASA (50 mg/kg/d)+ω-3 FAs as triglycerides in gastroresistant capsules, 3 g/d (eicosapentanoic acid, EPA, 400mg/g, docosahexaenoic acid, DHA, 200 mg/g). Group Ⅱ (20 patients) received 5-ASA (50 mg/kg/d)+olive oil placebo capsules. Patients were evaluated for fatty acid incorporation in red blood cell membranes by gas chromatography at baseline 6 and 12 mo after the treatment.RESUJLTS: The number of patients who relapsed at 1year was significantly lower in group Ⅰ than in group Ⅱ(P<0.001). Patients in group Ⅰ had a significant increase in the incorporation of EPA and DHA (P<0.001) and a decrease in the presence of arachidonic acids.CONCLUSION: Enteric-coated ω-3 FAs in addition to treatment with 5-ASA are effective in maintaining remission of pediatric CD. | C Romano S Cucchiara A Barabino V Annese C Sferlazzas SIGENP Italian Study Group of Pediatric Inflammatory Bowel Diseases | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 3 | Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification显示文摘AIM To undertook a systematic review to determine factors that increase a patient's risk of developing lower limb periprosthetic joint infections(PJI).METHODS This systematic review included full-text studies that reviewed risk factors of developing either a hip or knee PJI following a primary arthroplasty published from January 1998 to November 2016. A variety of keywords were used to identify studies through international databases referencing hip arthroplasty, knee arthroplasty, infection, and risk factors. Studies were only included if they included greater than 20 patients in their study cohort, and there was clear documentation of the statistical parameter used; specifically P-value, hazard ratio, relative risk, or/and odds ratio(OR). Furthermore a quality assessment criteria for the individual studies was undertaken to evaluate the presence of record and reporting bias. RESULTS Twenty-seven original studies reviewing risk factors relating to primary total hip and knee arthroplasty infections were included. Four studies(14.8%) reviewed PJI of the hip, 3(11.21%) of the knee, and 20(74.1%) reviewed both joints. Nineteen studies(70.4%) were retrospective and 8(29.6%) prospective. Record bias was identified in the majority of studies(66.7%). The definition of PJI varied amongst the studies but there was a general consensus to define infection by previously validated methods. The most significant risks were the use of preoperative high dose steroids(OR = 21.0, 95%CI: 3.5-127.2, P < 0.001), a BMI above 50(OR = 18.3, P < 0.001), tobacco use(OR = 12.76, 95%CI: 2.47-66.16, P= 0.017), body mass index below 20(OR = 6.00, 95%CI: 1.2-30.9, P = 0.033), diabetes(OR = 5.47, 95%CI: 1.77-16.97, P = 0.003), and coronary artery disease(OR = 5.10, 95%CI: 1.3-19.8, P = 0.017).CONCLUSION We have highlighted the need for the provider to optimise modifiable risk factors, and develop strategies to limit the impact of non-modifiable factors. | David A George Lorenzo Drago Sara Scarponi Enrico Gallazzi Fares S Haddad Carlo L Romano | 2017 | World Journal of Orthopedics2017，8，5： | 3 |
| 4 | Gemcitabine plus oxaliplatin (GEMOX) combined with cetuximab in patients with progressive advanced stage hepatocellular carcinoma:results of a multicenter phase 2 study显示文摘 | Asnacios A Fartoux L Romano O | | 0，，12： | 2 |
| 5 | Spiral computed tomography in the assessment of vascular lesions of the pelvis due to blunt trauma显示文摘 | Pinto A De Lutio Di Castelguidone E | 2000 | Radiol Med ( Torino)2000，100，12： | 1 |
| 6 | 5-lipoxygenase regulates malignant mesothelial cell survival: involvement of vascular endothelial growth factor 显示文摘 | Romano M Catalano A Nutini M | 2001 | FASEB J2001，15，6： | 1 |
| 7 | Biweekly administration of gemcitabine and vinorelbine as first line therapy in elderly advanced breast cancer 显示文摘 | Dinota A Bilancia D Romano R | 2005 | Breast Cancer Res Treat2005，89，1： | 1 |
| 8 | Production of mouse epidermal growth factor in yeast high-level secretion using Pichia pastoris strains containing muhiple gene copies 显示文摘 | CLARE J J ROMANOS M A RAYMENT F B | 1991 | 105:205 - 2121991，105，： | 1 |
| 9 | Experience of gemc?itabine plus oxaliplatin chemotherapy in patients with advanced bil?iary tract carcinoma 显示文摘 | Hollebecque A Bouche 0 Romano 0 | 2010 | Chemotherapy2010，56，3： | 1 |
| 10 | Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients 显示文摘 | Grassi R Romano S Pinto A | 2004 | Ear J Radiol2004，50，1： | 1 |
| 11 | Experience of gemcitabine plus oxaliplatin chemotherapy in patients with ad- vancedbiliary tract carcinoma显示文摘 | HOLLEBECQUE A BOUCHE O ROMANO O | 2010 | Chemotherapy2010，56，3： | 1 |
| 12 | Laparoscopic approach in abdominal emerg-encies显示文摘 | Agrusa A Romano G Di Buono G | | 0，，11： | 1 |
| 13 | Isocyanoacetate derivatives: Synthesis, reactivity, and application 显示文摘 | Anton V G Alexander G Z Romano V A O | 2010 | Chem Rev2010，110，： | 1 |
| 14 | Gene transfer technology in therapy:current applications and future goals显示文摘 | Romano G Pacilio C Giordano A | 1999 | Stem Cells1999，17，4： | 1 |
| 15 | Foreign gene expression in yeast显示文摘 | Romanos M A Scorer C A Clare J J | 1992 | Yeast1992，8，： | 1 |
| 16 | Adenovirus-mediated VEGF165 gene transfer enhances wound healing by promoting angiogenesis in CDI diabetic mice显示文摘 | S ROMANO DI PEPPE A MANGONI G ZAMBRUNO | 2002 | GENE THERAPY2002，9，19： | 1 |
| 17 | Laparoscopic approach in ab- dominal emergencies: a 5-year experience at a single center 显示文摘 | Agrusa A Romano G Di Buono G | 2012 | G Chir2012，33，1112： | 1 |
| 18 | Role of helical CT in diagnosis of gallstone ileus and related conditions显示文摘 | Lassandro F Romano S Ragozzino A | 2005 | AJR2005，185，5： | 1 |
| 19 | Hystvroscopy may be justified after two miscarriages显示文摘 | Weiss A Shalev E Romano S | 2005 | Hum Reprod2005，20，9： | 1 |
| 20 | Gemcitabine plus oxali- platin (GEMOX) combined with cetuximab in patients with pro- gressive advanced stage hepatocellular carcinoma : results of a mul- ticenter phase 2study显示文摘 | Asnaeios A Fartoux L Romano O | 2008 | Cancer2008，112，12： | 1 |
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