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| 1 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 2 | Usefulness of ω-3 fatty acid supplementation in addition to mesalazine in maintaining remission in pediatric Crohn's disease: A double-blind, randomized, placebo-controlled study显示文摘AIM: To assess the value of long-chain ω-3 fatty acids (FAs) supplementation in addition to amino-salicylic-acid (5-ASA) in pediatric patients with Crohn's disease (CD).METHODS: Thirty-eight patients (20 males and 18females, mean age 10.13 years, range 5-16 years)with CD in remission were randomized into two groups and treated for 12 mo. Group Ⅰ (18 patients) received 5-ASA (50 mg/kg/d)+ω-3 FAs as triglycerides in gastroresistant capsules, 3 g/d (eicosapentanoic acid, EPA, 400mg/g, docosahexaenoic acid, DHA, 200 mg/g). Group Ⅱ (20 patients) received 5-ASA (50 mg/kg/d)+olive oil placebo capsules. Patients were evaluated for fatty acid incorporation in red blood cell membranes by gas chromatography at baseline 6 and 12 mo after the treatment.RESUJLTS: The number of patients who relapsed at 1year was significantly lower in group Ⅰ than in group Ⅱ(P<0.001). Patients in group Ⅰ had a significant increase in the incorporation of EPA and DHA (P<0.001) and a decrease in the presence of arachidonic acids.CONCLUSION: Enteric-coated ω-3 FAs in addition to treatment with 5-ASA are effective in maintaining remission of pediatric CD. | C Romano S Cucchiara A Barabino V Annese C Sferlazzas SIGENP Italian Study Group of Pediatric Inflammatory Bowel Diseases | 2005 | World Journal of Gastroenterology2005，11，45： | 4 |
| 3 | Predicting lower limb periprosthetic joint infections: A review of risk factors and their classification显示文摘AIM To undertook a systematic review to determine factors that increase a patient's risk of developing lower limb periprosthetic joint infections(PJI).METHODS This systematic review included full-text studies that reviewed risk factors of developing either a hip or knee PJI following a primary arthroplasty published from January 1998 to November 2016. A variety of keywords were used to identify studies through international databases referencing hip arthroplasty, knee arthroplasty, infection, and risk factors. Studies were only included if they included greater than 20 patients in their study cohort, and there was clear documentation of the statistical parameter used; specifically P-value, hazard ratio, relative risk, or/and odds ratio(OR). Furthermore a quality assessment criteria for the individual studies was undertaken to evaluate the presence of record and reporting bias. RESULTS Twenty-seven original studies reviewing risk factors relating to primary total hip and knee arthroplasty infections were included. Four studies(14.8%) reviewed PJI of the hip, 3(11.21%) of the knee, and 20(74.1%) reviewed both joints. Nineteen studies(70.4%) were retrospective and 8(29.6%) prospective. Record bias was identified in the majority of studies(66.7%). The definition of PJI varied amongst the studies but there was a general consensus to define infection by previously validated methods. The most significant risks were the use of preoperative high dose steroids(OR = 21.0, 95%CI: 3.5-127.2, P < 0.001), a BMI above 50(OR = 18.3, P < 0.001), tobacco use(OR = 12.76, 95%CI: 2.47-66.16, P= 0.017), body mass index below 20(OR = 6.00, 95%CI: 1.2-30.9, P = 0.033), diabetes(OR = 5.47, 95%CI: 1.77-16.97, P = 0.003), and coronary artery disease(OR = 5.10, 95%CI: 1.3-19.8, P = 0.017).CONCLUSION We have highlighted the need for the provider to optimise modifiable risk factors, and develop strategies to limit the impact of non-modifiable factors. | David A George Lorenzo Drago Sara Scarponi Enrico Gallazzi Fares S Haddad Carlo L Romano | 2017 | World Journal of Orthopedics2017，8，5： | 3 |
| 4 | Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans 显示文摘 | ARCIONI R DELLA ROCCA M ROMANO S | 2002 | Anesth Analg2002，94，6： | 1 |
| 5 | Clinical recommenda- tions for avoiding and managing surgical complications associated with implant dentistry: a review 显示文摘 | S reenstein G Cavallaro J Romanos G | 2008 | J Periodont2008，79，8： | 1 |
| 6 | Gastro-duodenal perforations: conventional plain film, US and CT findings in 166 consecutive patients 显示文摘 | Grassi R Romano S Pinto A | 2004 | Ear J Radiol2004，50，1： | 1 |
| 7 | Current diagnosis and management ofsymptomatic intracranial atherosclerotic disease 显示文摘 | Prabhakaran S Romano JG | 2012 | Curr OpinNeurol2012，，： | 1 |
| 8 | Adenovirus-mediated VEGF165 gene transfer enhances wound healing by promoting angiogenesis in CDI diabetic mice显示文摘 | S ROMANO DI PEPPE A MANGONI G ZAMBRUNO | 2002 | GENE THERAPY2002，9，19： | 1 |
| 9 | Rapamycin stimulates apop- tosis of childhood acute lymphoblastic leukemia cells显示文摘 | AveUino R Romano S Parasole R | 2005 | Blood2005，106，： | 1 |
| 10 | Role of helical CT in diagnosis of gallstone ileus and related conditions显示文摘 | Lassandro F Romano S Ragozzino A | 2005 | AJR2005，185，5： | 1 |
| 11 | mi R-34c may protect lung cancer cells from paclitaxel-induced apoptosis显示文摘 | Catuogno S Cerchia L Romano G | 2013 | Oncogene2013，32，3： | 1 |
| 12 | Hystvroscopy may be justified after two miscarriages显示文摘 | Weiss A Shalev E Romano S | 2005 | Hum Reprod2005，20，9： | 1 |
| 13 | Thyroid cancer in pregnancy显示文摘 | Yasmeen S Cress R Romano PS | 2005 | Int J Gynaecol Obstet2005，91，1： | 1 |
| 14 | Hepatitis E in Italy: a long-term prospective study显示文摘 | Romano L Paladini S Tagliacarne C | 2011 | J Hepatol2011，54，1： | 1 |
| 15 | Acute tracheohronehiaI injuries: impact of imaging on diagnosis and management implications显示文摘 | Scaglione M Romano S Pinto A | 2006 | Eur J Radiol2006，59，3： | 1 |
| 16 | Phase noise in digital frequency dividers 显示文摘 | LEVANTINO S ROMANO L PELLERANO S | 2004 | IEEE Journal of Solid-State Circuits2004，39，5： | 1 |
| 17 | NUMB-ing down cancerby more than just a NOTCH显示文摘 | Pece S Confalonieri S?Romano P | 2011 | Biochim Biophys Acta2011，185，1： | 1 |
| 18 | The Promise and Peril of Cor- porate Governance Indices显示文摘 | Bhagat S Bohon B J Romano R | 2008 | Columbia Law Review2008，108，8： | 1 |
| 19 | Seven-year follow-up of cor- onary artery bypass performed with and without eardiopulmo- nary bypass 显示文摘 | Gundry S Romano M Shattuck O | 1998 | Journal of Thoracic and Cardiovascular Surger- y1998，115，02： | 1 |
| 20 | Phase Noise in Digital Frequency Dividers显示文摘 | Levantino S Romano L Pellerano S | 2004 | IEEE J of Solid-State Circuits2004，39，5： | 1 |
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