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| 1 | Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial显示文摘 | Ronald P DeMatteo Karla V Ballman Cristina R Antonescu Robert G Maki Peter WT Pisters George D Demetri Martin E Blackstein Charles D Blanke Margaret von Mehren Murray F Brennan Shreyaskumar Patel Martin D McCarter Jonathan A Polikoff Benjamin R Tan Kouros | 2009 | The Lancet2009，，9669： | 2 |
| 2 | A novel approach to digital beamforming显示文摘 | Roger G Pridham Ronald A Mucci | 1978 | J Acoust Soc Am1978，63，2： | 1 |
| 3 | Genetic support for the dual nature of attention deficit hyperactivity disorder:Substantial genetic overlap between the inattentive and hyperactive - impulsive components显示文摘 | McLougblin G Ronald A Kuntsi J | 2007 | J Abnorm Child Psychol2007，35，6： | 1 |
| 4 | The hnpact of the Alliance on the Partners: a Look at Cause- Brand Alliances 显示文摘 | Lafferty Barbara A Gold Smith Ronald E Huh G Tomas M | 2004 | Psychology & Marketing2004，21，7： | 1 |
| 5 | The global fi- nancial crisis : experiences of and implications for community - based organizations providing health and social services in South Africa显示文摘 | OLAGOKE A NETSAI B G RONALD L | 2016 | Critical Public Health2016，，263： | 1 |
| 6 | Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s:findings from the aberdeen children of the 1950s prospective cohort study显示文摘 | LAWLOR D A RONALDS G | 2005 | Circulation2005，6，10： | 1 |
| 7 | Ion exchange of cation-terminated poly(ethylene oxide) chains on mics surfaces显示文摘 | Michael O G Ronald A S Walter R C | 1997 | J Colloid Interface Sci1997，，189： | 1 |
| 8 | Electroantennogram response of alfalfa seed chalcid, Bruchophagus roddi (Hymenoptera: Eurytomidae) to host-and nonhost-plant volatiles 显示文摘 | Douglas M In James A K Ronald G R | 1992 | Journal of Chemical Ecology1992，18，3： | 1 |
| 9 | The psychosocial impact of macular degeneration显示文摘 | Williams Rebecca A Brody Barbara M P H Thomas Ronald G | 1998 | Archives of Ophthalmology1998，116，4： | 1 |
| 10 | Capital Structure: Perspectives For Managers显示文摘 | John C G Ronald C A | 1997 | Management Decision1997，35，7： | 1 |
| 11 | Real-time seam tracking forrobotic laser welding using trajectory-based control显示文摘 | Menno D G Ronald A Ben J | 2010 | ControlEngineering Practice2010，18，8： | 1 |
| 12 | Comparing scheduling rules for flexible flow lines显示文摘 | Mary E K Ronald G A | 2003 | Production Economics2003，85，： | 1 |
| 13 | Dacus dorsa- lis flies can learn to find and accept host fruit显示文摘 | RONALD J P THOMAS A G ROGER I V | 1990 | J Insect Behav1990，3，5： | 1 |
| 14 | The Kasai portoenterostomy for biliary atresia: a review of a 27-year experience with 81 patients显示文摘 | Barbara E Wildhaber Arnold G Coran Robert A Drongowski Ronald B Hirschl James D Geiger Joseph L Lelli Daniel H Teitelbaum | 2003 | Journal of Pediatric Surgery2003，，10： | 1 |
| 15 | Forming effective worker teams with multi-functional skill requirements显示文摘 | Erin L F Ronald G A | 2005 | Computers & Industrial Engineering2005，48，3： | 1 |
| 16 | Augmented Robust Estimators显示文摘 | Douglas C M | 1980 | Technometrics1980，22，3： | 1 |
| 17 | Suppress of the acquisition footprint for seismic sequence attribute mapping显示文摘 | Kurt J Marfurt Ronald M Scheet John A Sharp Mark G Harper | 1998 | Geophysics1998，63，3： | 1 |
| 18 | The psychosocial impact of macular degeneration显示文摘 | Rebecca A Barbara L Ronald G | 1998 | Arch 0phthalmol1998，116，： | 1 |
| 19 | Thermal activated ('thermal') battery technology Part Ⅲa:FeS2 cathode material显示文摘 | PATRICK J M RONALD A G | 2008 | Journal of Power Sources2008，177，： | 1 |
| 20 | Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo显示文摘AIM:To generate an adenoviral vector specifically targeting the EphA2 receptor(EphA2R) highly expressed on pancreatic cancer cells in vivo.METHODS:YSA,a small peptide ligand that binds the EphA2R with high affinity,was inserted into the HI loop of the adenovirus serotype 5 fiber knob.To further increase the specificity of this vector,binding sites for native adenoviral receptors,the coxsackie and adenovirus receptor(CAR) and integrin,were ablated from the viral capsid.The ablated retargeted adenoviral vector was produced on 293T cells.Specifi c targeting of this novel adenoviral vector to pancreatic cancer was investigated on established human pancreatic cancer cell lines.Upon demonstrating specifi c in vitro targeting,in vivo targeting to subcutaneous growing human pancreatic cancer was tested by intravenous and intraperitoneal administration of the ablated adenoviral vector.RESULTS:Ablation of native cellular binding sites reduced adenoviral transduction at least 100-fold.Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor.YSA-mediated transduction was inhibited by addition of synthetic YSA peptide.The transduction specificity of the ablated retargeted vector towards human pancreatic cancer cells was enhanced almost 10-fold in vitro.In a subsequent in vivo study in a nude(nu/nu) mouse model however,no increased adenoviral targeting to subcutaneously growing human pancreas cancer nodules was seen upon injection into the tail vein,nor upon injection into the peritoneum.CONCLUSION:Targeting the EphA2 receptor increases specificity of adenoviral transduction of human pancreatic cancer cells in vitro but fails to enhance pancreatic cancer transduction in vivo. | Michael A van Geer Conny T Bakker Naoya Koizumi Hiroyuki Mizuguchi John G Wesseling Ronald PJ Oude Elferink Piter J Bosma | 2009 | World Journal of Gastroenterology2009，15，22： | 1 |
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