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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Delayed leaf senescence induces extreme drought tolerance in a flowering plant显示文摘 | Rosa M R Mikiko K Amira G | 2007 | Proceedings of the National Academy of Sciences2007，104，19： | 1 |
| 3 | Is the application of carbendazimharmful to healthy plants?Evidence of weak phytotoxicity in tobacco显示文摘 | Pablo C G Juan M R Rosa M R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 4 | Pharmaco- logical evidences for the extracts and secondary metabolites from plants of the genus Hibiscus 显示文摘 | Maganha E G Halmenschlager R D Rosa R M | 2010 | Food Chemistry2010，118，1： | 1 |
| 5 | The role of the crust in the magmatic evolution of the island of Lipari (Aeolian Island, Italy) 显示文摘 | CRISCI G M de ROSA R | 1992 | Contrib Mineral Petrol1992，112，： | 1 |
| 6 | Multiresidue determination of 11 new fungicides in grapses and wines by liquid-liquid extraetion/clean-up and programmable temperature vaporization injection with analyte protectants/ gas chromatography/ion Irasp mass spectrometry 显示文摘 | Rosa M GonzAlez R Beatriz C G | 2009 | Journal of chromatography A2009，1216，： | 1 |
| 7 | Catalytic behavior of the Fe^3 +/Fe^2 + system in the electro-Fenton degradation of the antimicrobial chlorophene 显示文摘 | Ignasi S Jose A G Rosa M R | 2007 | Applied Catalysis B : Environmental2007，72，： | 1 |
| 8 | Real-time risk monitoring in business processes : A sensor-based approach显示文摘 | Conforti R Rosa M L Fortino G | 2013 | Journal of Systems & Software2013，86，11： | 1 |
| 9 | Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres显示文摘 | de Rosa G Iommelli R la Rotonda M I | 2000 | J Controlled Release2000，69，： | 1 |
| 10 | Comparison between metabolite productions in cell culture and in whole plant of Maclura pomifera 显示文摘 | Monache G D De Rosa M C Scurria R | 1995 | Phytochemistry1995，39，3： | 1 |
| 11 | Cadmium uptake and translocation in tumbleweed (Salsola kali), a potential Cd-hyperaccumulator desert plant species: ICP/OES and XAS studies显示文摘 | DE LA ROSA G PERALTA-VIDEA J R MONTES M | 2004 | Chemosphere2004，55，： | 1 |
| 12 | Flagella and motility in Actinobacillus pleuropneumoniae 显示文摘 | ERASMO N A MAGDA E R ROSA M G | 2003 | Bacterioilogy2003，185，2： | 1 |
| 13 | Binding of hepatitis C virus to CD81显示文摘 | Pileri P Uematsu Y Campagnoli S Galli G Falugi F Petracca R Weiner AJ Houghton M Rosa D Grandi G Abrignani S | | 0，，： | 1 |
| 14 | Mineralization of metoprolol by electro-Fenton and photoelectro-Fenton processes显示文摘 | Eloy I C Jose A G Rosa M R | 2011 | J Phys Chem A2011，115，7： | 1 |
| 15 | Catalytic behavior of the Fe^3+/Fe^2+ system in the electro-Fenton degradation of the antimicrobial chlorophene 显示文摘 | Ignasi S Jose A G Rosa M R | 2007 | Appl Catal B: Environ2007，72，34： | 1 |
| 16 | Determinationof 23 pesticide residues in leafy vegetables using gas chromatography-iontrap mass spectrometry and analyte protectants显示文摘 | ROSA M A RODRIGUEZ G RIAL-OTERO R | 2008 | Journal of Chro-matography A2008，，11961197： | 1 |
| 17 | Synchronization rate, size of the ovulatory follicle, and pregnancy rate after synchronization of ovulation beginning on different days of the estrous cycle in lactating dairy cows 显示文摘 | Vasconcelos J L M Silcox R W Rosa G J | 1999 | Theriogenology1999，52，： | 1 |
| 18 | Regulation of superoxide disnmtase activity by dietary manganese 显示文摘 | De Rosa G Keen C L Leach R M | 1980 | J Nutr1980，110，： | 1 |
| 19 | Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation显示文摘 | de la Rosa G Yanez Mo M Samaneigo R | 2005 | J Leukoc Biol2005，77，5： | 1 |
| 20 | DNA-cationic surfactant interactions are different for doubleand singlestranded DNA显示文摘 | Rosa M Dias R Miguel M G | 2005 | Biomacromolecules2005，6，4： | 1 |
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