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| 1 | Recent trends in the surgical management of inflammatory bowel disease显示文摘Surgery is required in the vast majority of patients with Crohn’s disease (CD) and in approximately one-third of patients with ulcerative colitis (UC). Similar to medical treatments for IBD, significant advances have occurred in surgery. Advances in CD include an emphasis upon conservatism as exemplified by more limited resections, strictureplasties, and laparoscopic resections. The use of probiotics in selected patients has improved the outcome in patients with pouchitis following restorative proctocolectomy for UC. It is anticipated that ongoing discoveries in the molecular basis of IBD will in turn identify those patients who will best respond to surgery. | Robert E Roses John L Rombeau | 2008 | World Journal of Gastroenterology2008，14，3： | 10 |
| 2 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 3 | An elastodynamic hybrid boundary element study for elastic guided wave interactions with a surface breaking defect显示文摘 | Younho Cho Rose J L | 2000 | Int J of Solids and Stru2000，37，23： | 2 |
| 4 | Wave reflection and transmission in beams containing delamination and inhomogeneity 显示文摘 | Wang C H Rose L R F | 2003 | Journal of Sound and Vibration2003，264，： | 1 |
| 5 | A method for the solubilization of a (1→3)-β-D-glucan isolated from Saccharomyces cerevisiae显示文摘 | Williams David L McNamee Rose B Jones Ernest L | 1991 | Carbohydrate Research1991，219，： | 1 |
| 6 | Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events 显示文摘 | Ridker PM Rifai N Rose L | 2002 | N Engl J Med2002，347，20： | 1 |
| 7 | Nursery and field fertilization of 2 + 0 ponderosa pine seedlings: the effect on morphology, physiology, and field performance 显示文摘 | Gleason J F Duryea M L Rose R | 1990 | Can J For Res1990，20，： | 1 |
| 8 | Intrinsic muscle flaps: the treatment of painful neuromas in continuity显示文摘 | ROSE J BELSKY M R MILLENDER L H | 1996 | J Hand Surg Am1996，21，4： | 1 |
| 9 | Guidelines on the diagnosis and management of the thrombotic microangiopathic haemolytic anaemias 显示文摘 | Allford S L Hunt BJ Rose P | 2003 | Br J Haemotol2003，120，4： | 1 |
| 10 | Ultrasonic guided wave and acoustic impact methods for pipe fouling detection显示文摘 | HAY T R ROSE J L | 2003 | Journal of Engineering2003，56，5： | 1 |
| 11 | Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events 显示文摘 | Richer PM Riled N Rose L Buring JE Cook NR | 2002 | N Engl J Med2002，347，20： | 1 |
| 12 | Early warning fire detection system using a probabilistic neural network 显示文摘 | SUSAN L ROSE P | 2003 | Fire Technology2003，39，： | 1 |
| 13 | Facade failure effects on blast propagation along city streets显示文摘 | SMITH P D ROSE T A KRAHE S L | 2003 | Structures and Buildings2003，156，4： | 1 |
| 14 | The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages显示文摘 | Whiteman M Li L Rose P | | 0，，10： | 1 |
| 15 | Excitation and propagation of non - axi- symmetric guided waves in a hollow cylinder 显示文摘 | LI Jian Rose J L | 2001 | Acoustical Society of American2001，109，2： | 1 |
| 16 | Interleukin-17 family and IL-17 receptors 显示文摘 | Moseley TA Haudenschild DR Rose L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 17 | Effects of human disturbances on the behavior of wintering ducks显示文摘 | PEASE M L ROSE R K BUTLER M J | 2005 | Wildlife Society Bulletin2005，33，1： | 1 |
| 18 | Credit Cards as Lifestyle Facilitators 显示文摘 | BERNTHAL M J CROCKETT D ROSE R L | 2005 | The Journal of Consumer Research2005，32，1： | 1 |
| 19 | Interleukin-17 family and IL-17 receptors显示文摘 | Moseley TA Haudenschild DR Rose L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 20 | Biochemical mechanisms and diagnostic microassays for pyrethroid, carbamate, and organophosphate insecticide resistance/ cross-resistance in the tobacco budworm, Heliothis virescens 显示文摘 | Zhao G Y Rose R L Hodgson E | 1996 | Pesticide Biochemistry and Physiology1996，56，3： | 1 |
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