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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging 显示文摘 | Marckmann P Skov L Rossen K | 2006 | J Am Soc Nephrol2006，17，： | 1 |
| 3 | Inhibition of PCRby components of food samples,microbial diagnostic assays and DNA-extraction solutions显示文摘 | ROSSEN L NORSKOV P HOLMSTROM K | 1992 | Int J Food Microbiol1992，17，1： | 1 |
| 4 | Media as a teaching tool in psy- chiatric nursing education显示文摘 | Wall B M Rossen E K | 2004 | Nurs Educ2004，29，1： | 1 |
| 5 | Inhibition of PCR by components of food samples,microbial diagnostic assays and DNA-extraction solutions显示文摘 | Rossen L Nrskov P Holmstrm K | 1992 | Int J Food Microbiol1992，17，1： | 1 |
| 6 | An improved finite-time ruin probability formula and its Mathematica implementation 显示文摘 | Ignatov Zvetan G Kaishev Vladimir K Krachunov Rossen S | 2001 | Insurance : Mathematics and Economics2001，29，： | 1 |
| 7 | Nephrogenic systemic fibrosis:suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging显示文摘 | Skov L Rossen K | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 8 | Nephrogenic Systemic Fibrosis: Suspected Causative Role of Gadodiamide Used for Contrast- enhanced Magnetic Resonance Imaging 显示文摘 | Marekmann P Skov L Rossen K | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 9 | Clinical supervision of nurses working with patients with borderline personality disorder 显示文摘 | Bland A R Rossen E K | 2005 | Issues Ment Health Nurs2005，26，5： | 1 |
| 10 | Inhibition of PCR by components of food samples, microbial diagnostic assays and DNA-extraction solutions显示文摘 | ROSSEN L NORSKOV P HOLMSTROM K | 1992 | Food Microbiology1992，17，： | 1 |
| 11 | CD56+ lyrnphoma with skin involvement:clinicopathologic features and classification显示文摘 | Rossen K Raltkier E | 2004 | Arch Dermatol2004，140，4： | 1 |
| 12 | CD56+ lymphoma with skin involvement: clinicopathologic features and classification显示文摘 | Gniadecki R Rossen K Ralfkier E | 2004 | Arch Dermatol2004，140，4： | 1 |
| 13 | Rotavirus enterotoxin NSP4 binds to the extracellular matrix proteins laminin-beta 3 and fibronectin显示文摘 | Boshuizen J A Rossen J W Sitaram C K | 2004 | J Virol2004，78，10： | 1 |
| 14 | Expression of Tcell activation marker CD134 (OX40) in lymphomatoid papulosis显示文摘 | Gniadecki R Rossen K | 2003 | Brit J Derma tol2003，148，5： | 1 |
| 15 | Nephrogenic systemic fibrosis : suspected causative role of gadodiamide used for contrast- enhanced magnetic resonance imaging 显示文摘 | Marckmann P Skov L Rossen K | 2006 | J Am Soc Nephrol2006，17，2： | 1 |
| 16 | Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging显示文摘 | Marckmann P Skov L Rossen K | 2006 | J Am Soc Nephrol2006，17，9： | 1 |
| 17 | Case-control study of gadodiamide-related nephrogenic systemic fibrosis显示文摘 | Marckmann P Skov L Rossen K | 2007 | Nephrol Dial Transplant2007，22，： | 1 |
| 18 | Synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677 显示文摘 | MALIGRES P E HOUPIS L ROSSEN K | 1997 | Tetrahedron1997，53，10： | 1 |
| 19 | Crystallizationinduced diastereoselection:Asymmetric synthesis of substance P inhibitors显示文摘 | Pye P J Rossen K Weissman S A | 2002 | Chem Eur J2002，8，： | 1 |
| 20 | Metallothionein expression in basaloid proliferations overlying dermatofibromas and in basal cell carcinomas 显示文摘 | Haerslev T Hou ensen K | 1997 | Br J Dermatol1997，136，1： | 1 |
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