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| 1 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 2 | Synthesis of 2,5-and 3,5-diphenylpyridine derivatives for DNA recognition andcytotoxicity显示文摘 | Jacquemard U Routier S Dias N | 2005 | Eur J Med Chem2005，40，11： | 1 |
| 3 | Synthesis and reac- tivity of 7-azaindole ( 1H-pyrrolo pyridine ) 显示文摘 | Popowycz F Routier S Joseph B | 2007 | Tetrahedron2007，63，5： | 1 |
| 4 | Synthesis and biological evaluation of 7-azaindolocarbazoles显示文摘 | Routier S Ayerbe N Merour J Y | 2002 | Tetrahedron2002，58，33： | 1 |
| 5 | Synthesis and biological e valuation of novel phenylcarbazoles as potential anticancer agents显示文摘 | Routier S Mérour JY Dias N | | 0，，02： | 1 |
| 6 | Efficient synthesis of 2 ,4- disubstituted pyrido pyrimidines involving SNAr and Suzuki-Miyaura cross coupling reactions显示文摘 | Tikad A Routier S Akssira M | 2010 | J Mar Chim Heter2010，9，1： | 1 |
| 7 | Free radical production byhydroxy-salen manganese complexes studied by ESR and XANES显示文摘 | VEZIN H LAMOUR E ROUTIER S | 2002 | Journal of Inorganic Biochemistry2002，92，34： | 1 |
| 8 | New efficient access to fused(Het) aryhetrahydroindolizinones via N-acyl iminium intermediates 显示文摘 | CHIURATO M BOULAHJAR R ROUTIER S | 2010 | Tetrahedron2010，66，25： | 1 |
| 9 | Synthesis and reactivity of-7-azaindole(1H-pyrrolopyridine)显示文摘 | Popowycz F Routier S Joseph B | 2007 | Tetrahedron2007，63，： | 1 |
| 10 | Packet train-measurements and a new model for computer network traffic 显示文摘 | Jain R Routier S | 1986 | JSAC1986，4，6： | 1 |
| 11 | Free radical production by hydroxy-salen manganese complexes studied by ESR and XANES 显示文摘 | VEZIN H LAMOUR E ROUTIER S | 2002 | Journal of Inorganic Biochemistry2002，92，： | 1 |
| 12 | Free radical production by hydroxy-salen manganese complexes studied by ESR and XANES 显示文摘 | Vezin H Lamour E Routier S | 2002 | Journal of Inorganic Biochemistry2002，92，34： | 1 |
| 13 | Free Radical Production by Hydroxy-Salen Manganese Complexes Studied by ESR and XANES 显示文摘 | Vezin H Lamour E Routier S | 2002 | Journal of Inorganic Biochemistry2002，92，34： | 1 |
| 14 | A mild and selective method for N -Boc deprotection显示文摘 | Routier S Sauge L Ayerbe N Coudert G Merour J - Y | 2002 | Tet- rahedron letters2002，43，4： | 1 |
| 15 | Mild and selective deprotection of carbamates with Bu4NF 显示文摘 | Jacquemard U Beneteau V Lefoix M Routier S Merour J -Y Coudert G | 2004 | Tetrahedron2004，60，10： | 1 |
| 16 | Free radical production by hydroxy-salen manganese complexes studied by ESR and XANES显示文摘 | Vezin H Lamour E Routier S | 2002 | Journal of Inorganic Biochemistry2002，92，： | 1 |
| 17 | 3D Visualization Applied to Electromagnetic Engineering 显示文摘 | CDR S ELBINGEZ Z USNR ROUTIER R | 1997 | Naval Engineers Journal1997，109，5： | 1 |
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