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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Nitric oxide-related oxidants in acute lung injury显示文摘 | ROYALL J A KOOY N W BEEKMAN J S | 1995 | New Horiz1995，3，1： | 1 |
| 3 | The ovalbumin gene regions:common features in the organisation of three genes expressed in chicken-oviduct under hormonal control显示文摘 | Royal A Garapin A C Cami B | 1979 | Nature1979，279，： | 1 |
| 4 | Identification of an a typical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2 dependent and-independent recruitment of Gab1 to receptor tyrosine kinases 显示文摘 | Lock L S Royal I Naujokas M A | 2000 | J Biol Chem2000，275，31： | 1 |
| 5 | Transcriptional activation of the neuronal peripherin-encoding gene depends on a G+C-rich element that binds Sp1 in vitro and in vivo显示文摘 | Desmarais D Royal A | 1995 | Gene1995，159，2： | 1 |
| 6 | Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and-independent recruitment of Gabl to receptor tyrosine kinases 显示文摘 | Lock L S Royal I Naujokas M A | 2000 | J Biol Chem2000，275，31： | 1 |
| 7 | Design principles for chutes to handle bulk solids显示文摘 | DICK D S ROYAL T A | 1992 | Bulk Solids Handling1992，12，3： | 1 |
| 8 | Nitric oxide related oxidants in acute lung injury显示文摘 | Royall J A Kooy N W Beckman J S | 1995 | New Heriz1995，3，： | 1 |
| 9 | Evaluation of 2',7'-dichlomrofluorescin and dihydrorhodamine 123 as fluorescent prubes for intracellular H2O2 in cultured endothelial cells显示文摘 | Royall J A Ischiropoulos H | 1993 | Arch Biochem Biophys1993，302，2： | 1 |
| 10 | The ovalbumin gene region : common features in the organisation of three genes expressed in chicken oviduct under hormonal control 显示文摘 | ROYAL A GARAPIN A CAMI B | 1979 | Nature1979，279，5709： | 1 |
| 11 | Evaluation of 2', 7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells 显示文摘 | Ischiropoulos H | 1993 | Arch Bioch Bio1993，302，： | 1 |
| 12 | Evidence for in vivo peroxy nitric production in human acute lung injury显示文摘 | Kooy N W Royall J A Ye Y Z | 1995 | Am J Respir CritCare Med1995，151，： | 1 |
| 13 | Strategies for Reversing the Trend Towards Subfertility in Dairy Ca'itle显示文摘 | Royal M Mann G E Flint A P F | 2000 | The Veterinary Jour- nal2000，160，1： | 1 |
| 14 | Expired breath hydrogen peroxide is a marker of acute airway inflammation in pediatric patients with asthma 显示文摘 | Dohlman A W Black H R Royall J A | 1993 | Am Rev Respir Dis1993，148，41： | 1 |
| 15 | Evidence for in vivo peroxynitrite production in human acute lung injury显示文摘 | KOOY N W ROYALL J A YE Y Z | 1995 | Am J Respir Crit Care Med1995，151，： | 1 |
| 16 | CLOX:an executive clock drawing task显示文摘 | Royall D R Cordes J A Polk M | 1998 | J Neurol Neurosurg Psychiatry1998，64，5： | 1 |
| 17 | Shock-induced chemical reactions in titanium-silicon powder mixtures of different morphologies: Time-resolved pressure measurements and materials analysis 显示文摘 | Thadhani N N Graham R A Royal T | 1997 | J Appl Phys1997，82，3： | 1 |
| 18 | Chronic fatigue syndrome: Clinical practice guidelines-2002显示文摘 | A Working Group convened under the auspices of the Royal Australasian College of Physicians | 2002 | The Medical Journal of Australia2002，176，： | 1 |
| 19 | Using Social Network Analysis to Evaluate Research Productivity and Collaborations显示文摘 | Royal K D Akers K S Lybarger M A | 2014 | The Journal of Faculty Development2014，28，1： | 1 |
| 20 | Understanding and eliminating particle segregation problems显示文摘 | CARSON J W ROYAL T A GOODWILL D J | 1986 | Bulk Solids Handling1986，6，1： | 1 |
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