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| 1 | Assessment of bone turnover and bone quality in type 2 diabetic bone disease: current concepts and future directions显示文摘Substantial evidence exists that in addition to the well-known complications of diabetes,increased fracture risk is an important morbidity.This risk is probably due to altered bone properties in diabetes.Circulating biochemical markers of bone turnover have been found to be decreased in type 2 diabetes(T2D) and may be predictive of fractures independently of bone mineral density(BMD).Serum sclerostin levels have been found to be increased in T2D and appear to be predictive of fracture risk independent of BMD.Bone imaging technologies,including trabecular bone score(TBS) and quantitative CT testing have revealed differences in diabetic bone as compared to non-diabetic individuals.Specifically,high resolution peripheral quantitative CT(HRp QCT) imaging has demonstrated increased cortical porosity in diabetic postmenopausal women.Other factors such as bone marrow fat saturation and advanced glycation endproduct(AGE) accumulation might also relate to bone cell function and fracture risk in diabetes.These data have increased our understanding of how T2D adversely impacts both bone metabolism and fracture risk. | Mishaela R Rubin Janina M Patsch | 2016 | Bone Research2016，4，1： | 10 |
| 2 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 3 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 4 | Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease显示文摘Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)cancers.However,these therapies can also induce autoimmune-like side effects in healthy tissue across the body.One of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI malignancies.We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology. | Alexa R Weingarden Samuel J S Rubin John Gubatan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 5 | Antimicrobial peptides and the gut microbiome in inflammatory bowel disease显示文摘Antimicrobial peptides(AMP)are highly diverse and dynamic molecules that are expressed by specific intestinal epithelial cells,Paneth cells,as well as immune cells in the gastrointestinal(GI)tract.They play critical roles in maintaining tolerance to gut microbiota and protecting against enteric infections.Given that disruptions in tolerance to commensal microbiota and loss of barrier function play major roles in the pathogenesis of inflammatory bowel disease(IBD)and converge on the function of AMP,the significance of AMP as potential biomarkers and novel therapeutic targets in IBD have been increasingly recognized in recent years.In this frontier article,we discuss the function and mechanisms of AMP in the GI tract,examine the interaction of AMP with the gut microbiome,explore the role of AMP in the pathogenesis of IBD,and review translational applications of AMP in patients with IBD. | John Gubatan Derek R Holman Christopher J Puntasecca Danielle Polevoi Samuel JS Rubin Stephan Rogalla | 2021 | World Journal of Gastroenterology2021，27，43： | 3 |
| 6 | Ionizing radiation activates transcription of the EGR gene via CArG elements显示文摘 | Datta R Rubin E Sukhatme V P | 1992 | Proc Natl Acad Sci U S A1992，89，10： | 2 |
| 7 | The propertiesof HDL in genetically engineered mice 显示文摘 | Schultz J R Rubin E M | 1994 | Curn Opin Lipidol1994，5，： | 2 |
| 8 | Inhibition of early atherogenesis in Transgenic mice by human apolipoprotein Al 显示文摘 | Rubin E M Krauss R M Spangler E A | 1991 | Nature1991，353，19： | 2 |
| 9 | The future of hip fractures in the United States:numbers,costs,and potential effects of postmenopausal estrogen显示文摘 | Cummings S R Rubin S M Black D | 1990 | Clinical Orthopaedics1990，252，： | 1 |
| 10 | Orbital reconstruction using porous polyethylene sheets 显示文摘 | RUBIN P A BILYK J R SHORE J W | 1994 | Ophthalmology1994，101，10： | 1 |
| 11 | Reappriaisal of partial lateral internal sphineterotomy 显示文摘 | Pernikoff BJ Eisenstat TE Rubin R J | 1994 | Dis Colon Rectum1994，37，10： | 1 |
| 12 | Role expecta- tions as antecedents of citizenship and the moderating effects of work context 显示文摘 | DIERDORFF E C RUBIN R S BACHRACH D G | 2012 | Journal of Management2012，38，2： | 1 |
| 13 | Regula- tion as the mother of innovation: the ease of SO2 Contrgl 显示文摘 | TAYLAR M R RUBIN E S HOUNSHELL D A | 2005 | Environmental Technology2005，27，2： | 1 |
| 14 | The anabolic effectsof parathyroid hormone 显示文摘 | Rubin MR Cosman F Lindsay R etal | 2002 | Osteoporos Int ’2002，13，4： | 1 |
| 15 | The influence of material build up around artifcial defects on rolling fatigue life and failuremechanism 显示文摘 | Dommarco R C Bastias P C Rubin C A | 2006 | Wear2006，260，： | 1 |
| 16 | Institutional ownership, volatility and dividends 显示文摘 | Rubin A Smith D R | 2009 | Journal of Banking & Finance2009，33，： | 1 |
| 17 | A rapid protein profiling system that speeds study of cancer and other diseases显示文摘 | Rubin R B Merchant M | 2000 | Am Clin Lab2000，19，8： | 1 |
| 18 | Tissue microarray sampling strategy for prostate cancer biomarker analysis显示文摘 | Rubin MA Dunn R Strawderman M | 2002 | Am J Surg Pathol2002，26，3： | 1 |
| 19 | AIR Trial Study Group : Long term (5 Year) safety of bronchial thermoplasty : Asthma Intervention Research(AIR)trial显示文摘 | Thomson N Rubin A Niven R | 2011 | BMC Pulm Med2011，11，： | 1 |
| 20 | A randomized phase Ⅱ trial of two schedules of docetaxel in elderly or poor performance status patients with advance non-small cell lung cancer显示文摘 | Lilenbaum R Rubin M Samuel J | 2007 | J Thorac Oncol2007，2，4： | 1 |
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