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| 1 | Influences of Ivabradine treatment on serum levels of cardiac biomarkers sST2, GDF-15, suPAR and H-FABP in patients with chronic heart failure显示文摘长期的心失败(CHF ) 代表住院和死亡的一个主要原因。最近的证据表演那新奇 biomarkers 象 tumorigenicity (sST2 ) 的可溶的抑制那样,生长区别 factor-15 (GDF-15 ) ,可溶的尿激 plasminogen 使活跃之物受体(suPAR ) 和心类型丰满的酸绑定蛋白质(H-FABP ) 被相关与煽动性并且在 CHF 病人的 ischemic 回答。在这研究,我们检验了禁止了 激活hyperpolarization 的周期的核苷酸门隧道的 Ivabradine 的效果( HCN 隧道,也叫的滑稽电流我 从而导致选择心率减小的 f ),和改进的心肌的氧在心脏的 biomarkers sST2 上供应, GDF-15 ,在在 Jena 的大学医院的 50 个 CHF 病人的 suPAR 和 H-FABP 。病人们基于 CHF 的病原学被划分成三个组:扩大心肌症(DCM, n=20 ) , ischemic 心肌症(ICM, n=20 ) 并且高血压的心肌症(HCM, n=10 ) 。病人是管理 Ivabradine (5 mg,为 3 个月的出价,和 7.5 mg 期望推进 3 个月) 。心血管的 biomarkers 的分析在基线以及在 3 月、 6 月的后续被执行。在 6 月的后续, GDF-15 层次显著地与基线层次(P=0.0215 ) 相比被减少,显示在心脏的改变的进步的减小。H-FABP 集中在与 ICM (1.89 对 3.24 g/mL ) 和 HCM 病人(1.89 对 3.80 g/mL ) 相比的 DCM 病人是显著地更低的,并且在 6 月的后续(P=0.0151 ) 上减少了。中部的层次仍然是的 suPAR 提高了,暗示主要进行中的煽动性的过程。是在 GDF-15 和 H-FABP 由重要减少证明层次,在室的改变的减小和无临床症状的局部缺血能被假定。然而,血液动力学的应力(sST2 ) 的标记和发炎(suPAR ) 没在 CHF 病人在 6 月 Ivabradine 治疗以后显示出变化或前进。进一步的研究是必要的验证这些新奇心血管的 biomarkers 的临床的适用性。 | Peter JIRAK Dzeneta FEJZIC Vera PAAR Bernhard WERNLY Rudin PISTULLI Ilonka ROHM Christian JUNG Uta C HOPPE P Christian SCHULZE Michael LICHTENAUER Atilla YILMAZ Daniel KRETZSCHMAR | 2018 | Acta Pharmacologica Sinica2018，39，7： | 31 |
| 2 | 抑制次同步谐振的TCSC主动阻尼控制显示文摘采用同步电压反转(synchronous voltage reversal,SVR)触发控制的可控串联补偿电容(thristor controlled series compensator,TCSC)本身不会诱发系统的次同步谐振(sub-synchronous resonance SSR),而且因为其在次同步频率范围内固有的感性阻抗特性,一直以来工程中都把TCSC作为一种缓解SSR的有效措施。虽然采用SVR触发的TCSC可缓解系统SSR的压力,但其本身却无法主动抑制SSR,该文提出一种TCSC的附加控制——主动阻尼控制,通过调节TCSC的触发,可使系统在危险振荡模式下向机组提供正值的电气阻尼,从而更好地抑制SSR。时域及频域的仿真也验证了该主动阻尼控制的有效性。 | 周长春 刘前进 Lennart Angquist Staffan Rudin | 2008 | 中国电机工程学报2008，28，10： | 19 |
| 3 | The Promise of Pharmacogenomics in ReducingToxicity During Acute Lymphoblastic LeukemiaMaintenance Treatment显示文摘Pediatric acute lymphoblastic leukemia(ALL) affects a substantial number of children every year and requires a long and rigorous course of chemotherapy treatments in three stages, with the longest phase, the maintenance phase, lasting 2–3 years. While the primary drugs used in the maintenance phase, 6-mercaptopurine(6-MP) and methotrexate(MTX), are necessary for decreasing risk of relapse, they also have potentially serious toxicities, including myelosuppression, which may be life-threatening, and gastrointestinal toxicity. For both drugs, pharmacogenomic factors have been identified that could explain a large amount of the variance in toxicity between patients, and may serve as effective predictors of toxicity during the maintenance phase of ALL treatment.6-MP toxicity is associated with polymorphisms in the genes encoding thiopurine methyltransferase(TPMT), nudix hydrolase 15(NUDT15), and potentially inosine triphosphatase(ITPA), which vary between ethnic groups. Moreover, MTX toxicity is associated with polymorphisms in genes encoding solute carrier organic anion transporter family member 1B1(SLCO1B1) and dihydrofolate reductase(DHFR). Additional polymorphisms potentially associated with toxicities for MTX have also been identified, including those in the genes encoding solute carrier family 19 member 1(SLC19A1)and thymidylate synthetase(TYMS), but their contributions have not yet been well quantified. It is clear that pharmacogenomics should be incorporated as a dosage-calibrating tool in pediatric ALL treatment in order to predict and minimize the occurrence of serious toxicities for these patients. | Shoshana Rudin Marcus Marable R. Stephanie Huang | 2017 | Genomics, Proteomics & Bioinformatics2017，15，2： | 5 |
| 4 | Frequently overlooked and rarely listened to: Music therapy in gastrointestinal endoscopic procedures显示文摘To elucidate the role of music therapy in gastrointestinal endoscopic procedures following the conflicting outcomes reported in two recent studies. The findings of our recent meta-analysis that examined this matter were discussed in the context of later studies. Our meta-analysis illustrated the beneficial effects of music therapy on patient anxiety levels when used as a single measure of relaxation and analgesia. Beneficial effects were also shown on analgesia and sedation requirements and procedure duration times when used as an adjunct to pharmacotherapy. These findings are in agreement with those of both studies excluded from analysis and those that followed it. Music therapy is an effective tool for stress relief and analgesia in patients undergoing gastrointestinal endoscopic procedures. | Dan Rudin | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 5 | Feature-oriented image enhancement using shock filters 显示文摘 | Leonid I Rudin Stanley Osher | 1990 | SIAM Journal on Numerical Analysis1990，27，4： | 1 |
| 6 | Nonlinear total variation based noise removal algorithms显示文摘 | RUDIN L I OSHER S FATEMI E | 1992 | Physica D1992，60，： | 1 |
| 7 | Nonlinear total variation based noise removal algorithms显示文摘 | Rudin L Osher S Fatemi E | 1992 | Physics D1992，60，： | 1 |
| 8 | Lung cancer in never smokers: molecular profiles and therapeutic implications 显示文摘 | Rudin CM Avila-Tang E Harris CC | 2009 | Clin Cancer Res2009，15，18： | 1 |
| 9 | Uniqueness theory for Laplace series 显示文摘 | Rudin W | 1950 | Trans Amer Math Soc1950，68，： | 1 |
| 10 | Feature-oriented image enhancement using shock filters 显示文摘 | Osher S J Rudin L I | 1990 | SIAM Journal of Numerical Analysis1990，27，4： | 1 |
| 11 | Feature-oriented image enhancement using shock filters显示文摘 | OSHER S J RUDIN L I | 1990 | SIAM Journal on Numerical Analysis1990，27，4： | 1 |
| 12 | A phase II study of obatoclax mesylate, a Bcl-2 antagonist, plus topoteean in relapsed small cell lung cancer显示文摘 | Paik PK Rudin CM Pietanza MC | 2011 | Lung Cancer2011，74，： | 1 |
| 13 | A Study on the Crystallization Behaviour of Polypropylene/Polyethylene and Their Blends by Dynamic Mechanical and Thermal Methods 显示文摘 | Teh J W Blom H P Rudin A | 1994 | Polymer1994，35，： | 1 |
| 14 | Nonlinear Total Veriation Based Noise Removal Algorithms显示文摘 | Rudin L Osher S Fatemi E | 1992 | Physica D1992，，60： | 1 |
| 15 | Nonlinear total variation based noise removal algorithms 显示文摘 | Rudin L Osher S Fatemi E | 1992 | Physica D (S0167-2789)1992，60，： | 1 |
| 16 | Nonlinear total variation based noise removal algorithms 显示文摘 | RUDIN L OSHER S FATEMI E | 1992 | Physiea D1992，，60： | 1 |
| 17 | Nonlinear total variation noise removal algorithm显示文摘 | RUDIN L I 'OSHER S FATEMI E | 1992 | Physica D1992，60，14： | 1 |
| 18 | Nonlinear total variation based noise removal algorithms显示文摘 | Rudin L I Osher S Fatemi E | 1992 | Physica D:Nonlinear phenomena1992，60，1234： | 1 |
| 19 | Nonlinear total variation based noi re- moval algorithms 显示文摘 | Rudin L Osher S Fatemi E | 1992 | PhysJca D1992，60，1： | 1 |
| 20 | Nonlinear total variation based noise removal algorithms显示文摘 | Leonid I Rudin Stanley Osher Emad Fatemi | 1992 | Physica D1992，60，14： | 1 |
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