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| 1 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 2 | Effects of acute stress]on blood dotting and yeast killing by phagocytes of rainbow trout显示文摘 | RUIS M A W BAYNE C J | 1997 | Journal of Aquatic Animal Health1997，9，： | 1 |
| 3 | The unique enve lope gene of the subgroup J avian leukosis virus de rives from ev/J provirus, a novel family of avian en dogenous viruses显示文摘 | Benson S J Ruis B Fadly A M | 1998 | J Virol1998，72，10： | 1 |
| 4 | Principal component analysis as tool of characterization of quince (Cydonia oblonga Miller) jam 显示文摘 | Branca M S Paula B A Rui C M | 2006 | Food Chemistry2006，94，4： | 1 |
| 5 | Persistence and Global Stability of a Ratio-Dependent Predator-Prey Model with Stage Structure显示文摘 | Chaplain M A J Davidson F A | 2004 | Appl Math Comput2004，158，： | 1 |
| 6 | Expression of defender against apoptotic death (DAD-1) in lr/s and Dianthus petals显示文摘 | Van Der Kop D A M Ruys G Dees D | 2003 | Physiolo- gia Plantarum2003，117，2： | 1 |
| 7 | Precipitation of hydroxyapatite nanoparticles:effects of precipitation method on electrophoretic deposition显示文摘 | Wei M Ruys A J Milthorpe B K | 2005 | Journal of Materials Science:Materials in Medicine2005，16，4： | 1 |
| 8 | Permanence and periodicity of a delayed ratio-dependent predator-prey model withstage structure显示文摘 | Xu Rui Chaplain M A J Davidson F A | 2005 | Math Anal Appl2005，303，： | 1 |
| 9 | Mutual information:a measure of dependency for nonlineartime series 显示文摘 | Andreia D Rui M Diana A M | 2004 | Physica A2004，344，2： | 1 |
| 10 | Coupling of acrylic dyeing wastewater treatment by heterogeneous Fenton oxidation in a continuous stirred tank reactor with biological degradation in a sequential batch reactor 显示文摘 | Esteves B M Rodrigues C S D Boaventura Rui A R | 2016 | Journal of Environmental Management2016，166，： | 1 |
| 11 | Sensitivity and accuracy of quantitative realtime polymerase chain reaction using SYBR green I depends on cDNA synthesis conditions 显示文摘 | LEKANNE DEPREZ R H FIJNVANDRAAT A C RUI JTER J M | 2002 | Analytical Biochemistry2002，307，： | 1 |
| 12 | Mutual information: a measure of dependency for nonlinear time series显示文摘 | Andreia D Rui M Diana A M | 2004 | Physica A2004，344，2： | 1 |
| 13 | Fenton oxidation of cork cooking wastewater-overall kinetic analysis 显示文摘 | Anabela M F M Guedes Luis M P Madeira Rui A R Boaventura | 2003 | Water Research2003，37，13： | 1 |
| 14 | Eleetrophoretie Deposition of Hydroxyapatite Coatings on Metal Sub- strates: A Nanoparticulate Dual-Coating Approach显示文摘 | Wei M Ruys A J Milthorpe B K | 2001 | Journal of Sol-Gel Science and Technology2001，21，： | 1 |
| 15 | Global stability for a delayed ratio-dependent predator-prey system without dominating instantaneous negative feedbacks显示文摘 | Rui Xu Chaplain M A J Lansun Chen | 2001 | Communications on Applied Nonlinear Analysis2001，8，4： | 1 |
| 16 | A systematic review of the role of intrapartum hypoxia-ischemia in the causation of neonatal encephalopathy 显示文摘 | ] Graham E M Ruis K A Hartman A L | 2008 | Am J Obstetr Gyneco12008，199，6： | 1 |
| 17 | Periodic Solutions for A Predator-prey Model with Holling-type Functional Response and Time Delay显示文摘 | Xu Rui Chaplin M A Davidson F A | 2005 | Appl Math Comput2005，161，： | 1 |
| 18 | Personalities in female domesticated pigs:behavioural and physiological indications显示文摘 | Ruis M A W te Brake J H A van de Burgwal J A | 2000 | Appl Anim Behav Sci2000，66，： | 1 |
| 19 | Optimization of the azo dye Procion Red H-EXL degradation by Fenton's reagent using experimental design 显示文摘 | Carmen S D Rodrigues Luis M Madeira Rui A R Boaventura | 2009 | Journal of Hazardous Materials2009，164，2： | 1 |
| 20 | Interfacial bond strength of electrophoretically deposited hydroxyapatite coatings on metals 显示文摘 | Wei M Ruys A J Swain M V | 1999 | J Mater Sci : Mater Med1999，10，： | 1 |
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