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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 3 | Germanium recovery from gasification fly ash: Evaluation of end-products obtained by precipitation methods 显示文摘 | ARROYO F FONT O FERNANDEZ-PEREIRA C QUEROL X JUAN R RUIZ C COCA P | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 4 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSO-GARCIA M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials & Solar Cells2006，90，3： | 1 |
| 5 | Fast and selective determination of triterpenic compounds in olive leaves by liquid chromatography tandem mass spectrometry with multiple reaction monitoring after microwave-assisted extraction显示文摘 | SANCHEZ A N PRIEGO C F RUIZ J J | 2009 | Talanta2009，78，1： | 1 |
| 6 | Restoration SPOT images using PSF-drived deconvolution filters 显示文摘 | Ruiz C P Ariza Lopez F J | 2002 | International Journal of Remote Sensing2002，23，12： | 1 |
| 7 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSO-GARC1A M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials and Solar Cells2006，90，3： | 1 |
| 8 | Global spread of microorganisms by ships显示文摘 | Ruiz G M Rawlings T K Dobbs F C | 2000 | Nature2000，408，6808： | 1 |
| 9 | Comparative bioaccumulation of tracemetal in Penaeussty cirostrisine stuarine and wastal environments 显示文摘 | Paez O F Ruiz F C | 1995 | Estuarine Coastal and Shelf Sciende1995，40，1： | 1 |
| 10 | Modelling Austenite Flow Curves in Low Alloy and Microalloyed Steels显示文摘 | Hernandez C A Medina S F Ruiz J | 1996 | Acta Materialia1996，44，1： | 1 |
| 11 | Aldose reductasest ructures: implica- tions for mechanism and inhibition 显示文摘 | EKE Ruiz F Darmanin C | 2004 | Cell Mol Life Sci2004，61，78： | 1 |
| 12 | Modeling austenite flow curve in low alloy and microalloyed steel显示文摘 | HERNADEZ C A MEDINA S F RUIZ J | 1996 | Acta Mater1996，44，1： | 1 |
| 13 | Experimental study of mismatch and shading effects in the I-V characteristic of a photovoltaic module 显示文摘 | ALONSOGARCIA M C RUIZ J M CHENLO F | 2006 | Solar Energy Materials & Solar Cells2006，，90： | 1 |
| 14 | Recycling of an electric arc furnace flue dust to obtain high grade ZnO显示文摘 | RUIZ 0 CLEMENTE C ALONSO M ALGUACIL F J | 2007 | Journal of Hazardous Materials2007，141，1： | 1 |
| 15 | Discharge of Nutrients from Shrimp Farming to Coastal Waters of the Gulf of California显示文摘 | Paez-osuna F Guerrro S R Ruiz A C | 1999 | Marine Pollution Bulletin1999，38，7： | 1 |
| 16 | Analytical speciation as a tool to assess arsenic behaviour in soils polluted by mining显示文摘 | RUIZ C M J LOPEZ S J F RUBIO R | 2007 | Analytical and Bioanalytical Chemistry2007，387，： | 1 |
| 17 | Aldose reductase structures: implications for mechanism and inhibition 显示文摘 | E1-Kabbani O Ruiz F Darmanin C | 2004 | Cell Mol Life Sci2004，61，78： | 1 |
| 18 | Coal mine methane:a review of capture and utilization practices with benefits to mining safety and to greenhouse gas reduction显示文摘 | Karacan C (O) Ruiz F A Cotè M | | 0，，： | 1 |
| 19 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 20 | New approaches to the extraction of arsenic species from soils显示文摘 | RUIZ C M J SABE R LOPEZ S J F | 2005 | Microchimica Acta2005，151，： | 1 |
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