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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Flexural strength of feldspathic porcelain treated with ion exchange, overglaze and polishing显示文摘 | Russell A Giordano R A 2nd Campbell S | 1994 | J Prosthet Dent1994，71，： | 2 |
| 3 | Silver based batteries for high power applications 显示文摘 | KARPINSKI A P RUSSELL S J SERENYI J R | 2000 | Joumal of Power Sources2000，91，： | 1 |
| 4 | Modeling the crystal-field splitting of energy levels of Era* (4f11 ) in charge-compensated sites of KPbzC15 显示文摘 | GRUBER J B YOW R M NIJJAR A S NIJJAR C RUSSELL C SARDAR D J | 2006 | J Appl Phys2006，100，04： | 1 |
| 5 | Unitary Integrators and Applications to Continuous Othonormalization Techniques显示文摘 | DIECI L RUSSELL R D VAN Vleck E S | 1994 | SIAM J Numer Anal1994，31，： | 1 |
| 6 | Inhibition, inactiva- tion, and recovery of ammonia-oxidizing activity in cometabolism of trichloroethylene by nitrosomonas-eumpaea显示文摘 | HYMAN M R RUSSELL S A ELY R L | 1995 | Applied and Environ- mental Microbiology1995，61，4： | 1 |
| 7 | Ante- cedents and Consequences of the Perceived Adjust ment of Japanese Expatriates in the USA 显示文摘 | TAKEUCHI R YUN S RUSSELL J E A | 2001 | Inter- national Journal of Human Resource Management2001，13，8： | 1 |
| 8 | Plant Root Systems: Their Function and Interaction with the Soil显示文摘 | Russell R S | 1978 | Journal of Applied Ecology1978，125，4： | 1 |
| 9 | Engireering targe- ted viral vectors for gene therapy显示文摘 | WAEHLER R RUSSELL S J CURIEL D T | 2007 | Nat Rev Genet2007，8，8： | 1 |
| 10 | Technological change, techno- logical catch up, and capital deepening:relative contribu- tions to growth and convergence 显示文摘 | KUMAR S RUSSELL R R | 2002 | American Economic Review2002，92，3： | 1 |
| 11 | Technological change, technologi- cal catch-up and capital deepening: Relative contributions to growth and convergence显示文摘 | Kumar S Russell R R | 2002 | American Economic Review2002，92，3： | 1 |
| 12 | Advan- tages of a single-cycle production assay to study cell culture- adaptive mutations of hepatitis C virus显示文摘 | RUSSELL R S MEUNIER J C TAKIKAWA S | 2008 | Proceedings of the Na- tional Academy of Sciences USA2008，105，11： | 1 |
| 13 | Advantages of a single-cycle production assay to study cell culture-adaptive mutationsof hepatitis C virus显示文摘 | Russell R S Meunier J C Takikawa S | 2008 | Proc Natl Acad Sci USA2008，105，11： | 1 |
| 14 | Orexin A interactions in the hypothalamo-pituitary gonadal axis 显示文摘 | Russell S H Snlall C J Kennedy A R | 2001 | Endocrinol2001，142，12： | 1 |
| 15 | Isolation of S-locus F-box alleles in Prunus avium and their application in a novel method to determine self-incompatibility genotype显示文摘 | VAUGHAN S P RUSSELL K SARGENT D J TOBUTT K R | 2006 | Theor Appl Genet2006，112，： | 1 |
| 16 | Induction of cytochrome c-mediated apoptosis by amyloid β 25- 35 requires functional mitochondria 显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 17 | Molecular characterization of MPT83 :a seroreactive antigen of Mycobacterium tuberculosis with homology to MPT70显示文摘 | Hewinson R G Michell S L Russell W P | 1996 | Scand J Immunol1996，43，5： | 1 |
| 18 | Induction of cytochrome e-mediated apoptosis by amyloid β 25-35 requires functional mitochondria显示文摘 | Sandra M C Russell H S Catarina R O | 2002 | Brain Research2002，931，2： | 1 |
| 19 | Land-use a-nd land-cover dynamics in response to changes in cli-matic,biological and socio-political forces:the caseof southwestern Ethiop显示文摘 | Reid R S Russell L K Nvawira M | 2000 | Landscape Ecology2000，15，： | 1 |
| 20 | Biochemistry and immunology of infectious bursal disease virus显示文摘 | Kibenge F S B Dhillon A S Russell R G | | 0，，08： | 1 |
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