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| 1 | 决定新生儿脓毒性休克转归和预后的因素显示文摘背景有关新生儿脓毒性休克转归和预后的资料相对缺乏。目的描述新生儿脓毒性休克的转归,研究与死亡或负面转归相关的因素。设计回顾性队列研究。场所一所大学医院的三级NICU。对象6年期间所有符合下述标准的NICU患儿:证实或高度怀疑感染;伴低血压和(或)需液体复苏或血管活性药物治疗。干预无。测量指标和主要结果主要转归指标为28d病死率,负面转归定义为纠正年龄18个月时确定死亡或存在严重后遗症(脑瘫、严重发育迟缓、听力损害、致盲或短肠综合征)。共有48例患儿纳入研究,其中46例在纠正年龄18个月时获得随访数据。结果发现,28d病死率为40%(19例死亡);24例在纠正年龄18个月时观察到负面转归(病死率为52%;死亡19例,严重后遗症5例)。总计28%的患儿存活且18个月时检查正常。有负面转归的患儿孕周、出生体重、Apgar评分、发生脓毒症时的体质量、pH值均偏低。差异具有显著性。更常见的负面因素包括革兰阴性菌感染、胎儿发育迟缓、低血糖和血小板减少。经多因素分析,对28d病死率和纠正年龄18个月时负面转归较有意义的预测因素是脓毒症发生时体重(OR值分别为0.14、0.21;95%a分别为0.03~0.55、0.06~0.74),以及革兰阴性菌感染(OR值分别为10.1、45.5;95%CI分别为1.5~65.7.3~637)。结论新生儿脓毒性休克的转归很差。研究结果强调极低出生体重儿对脓毒性休克,尤其革兰阴性菌感染所致者抵抗力极差。 | Kermorvant-Duchemin E Laborie S Rabilloud M | 2008 | 中国小儿急救医学2008，15，2： | 2 |
| 2 | Silver staining of proteins in polyaerylamide gels 显示文摘 | Chevallet M Luehe S Rabilloud T | 2006 | Nat Protoe2006，1，4： | 1 |
| 3 | Two - dimensional electrophoresis of human placental mitochondria and protein i- dentification by mass spectrometry: toward a human mitochon- drial proteome 显示文摘 | Rabilloud T Kieffer S Procaccio V | 1998 | Electrophoresis1998，19，6： | 1 |
| 4 | Two-dimensional electrophoresis of proteins discriminates aphid clones of Sitobion avenae differing in BYDV-PAV transmission显示文摘 | Papura D Jacquot E Dedryver C A Luche S Riault G Bossis M Rabilloud T | | 0，，： | 1 |
| 5 | The mitochondrial antioxidant defence system and its response to oxidative stress 显示文摘 | RABILLOUD T HELLE M | 2001 | Proteomics2001，1，9： | 1 |
| 6 | Improvement and simplification of low-background silver staining of protein by using sodium dithionite 显示文摘 | Rabilloud T Carpentier G Tarroux P | 1998 | Electmphoresis1998，9，： | 1 |
| 7 | Two-dimensional gel electrophoresis in proteomies: old, old fashioned, but it still elimbs up the mountains 显示文摘 | Rabilloud T | 2002 | Proteomies2002，2，： | 1 |
| 8 | Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 weeks gestation (DOMINOS study)显示文摘 | Pasquier JC Picaud JC Rabilloud M | 2009 | Eur J Obstet Gynecol Reprod Biol2009，143，： | 1 |
| 9 | Sample application by in-gel rehydration improves the resolution of two dimensional electrophoresis with immobilized pH gradients in the first dimension显示文摘 | Rabilloud T H Ualette C Lawrence J J | 1994 | Electrophoresis1994，15，： | 1 |
| 10 | Solubilization of proteins in 2-D electrophoresis:an outline显示文摘 | RABILLOUD T | 1999 | Methods Mol Biol1999，12，： | 1 |
| 11 | Silver staining of proteins in polyacrylamide gels显示文摘 | Chevallet M Luche S Rabilloud T | 2006 | Nat Protocol2006，1，4： | 1 |
| 12 | Improvement of the solubilization of proteins in two-dimensional electrophoresis with immobilized pH gradients显示文摘 | RABILLOUD T ADESSI C GIRAUDEL | 1997 | Electrophoresis1997，18，34： | 1 |
| 13 | Multidimensional separation prior to mass spectrometry: getting closer to the bottom of the iceberg 显示文摘 | Mayr M Rabilloud T | 2013 | Proteomics2013，13，20： | 1 |
| 14 | Neonatal outcomes after elective delivery management of preterm premature rupture of the membranes before 34 week' s gestation ( DOMINOS study ) 显示文摘 | Pasquier JC Picaud JC Rabilloud M | 2009 | Eur J Obstet Gynecol Reprod Biol2009，，143： | 1 |
| 15 | Two-dimensional gel electrophoresis in proteomics: old fashioned, but it still climbs up the mountains显示文摘 | Rabilloud T | 2002 | Proteomics2002，2，1： | 1 |
| 16 | Two-dimensional gel electrophoresis in proteomics:old,old fashioned,but it still climbs up the mountains显示文摘 | Rabilloud T | 2002 | Proteomics2002，2，1： | 1 |
| 17 | Solubilization of protein for electrophoretic analyses显示文摘 | Rabilloud T | 1996 | Electrophoresis1996，17，5： | 1 |
| 18 | Three-dimensional organization of thyroid cells into follicle structures is a pivotal factor in the control of sodium/iodide symporter expression 显示文摘 | Bemier-Valentin F Trouttet-Masson S Rabilloud R | 2006 | Endocrinology2006，147，4： | 1 |
| 19 | Two-dimensional electrophoresis of human placental mitochondria and protein identification by mass spectrometry:toward a human mitochodrial proteome 显示文摘 | Rabilloud T Kieffer S Procaccio V | 1998 | Electrophoresis1998，19，： | 1 |
| 20 | A nonradio- active double detection method for the assignment of spots in two dimensional blots 显示文摘 | Chewallet M Procaccio V Rabilloud T | 1997 | Analytical Biochemistry1997，251，1： | 1 |
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