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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Angiotensin Ⅱ and the fibroproliferative response to acute lung injury显示文摘 | Richard P M Peter G Rachel C | 2004 | Am J Physiol Lung Cell Mol Physiol2004，286，： | 2 |
| 3 | School-based intervention for adolescents with social anxiety disorder:Result of a controlled study显示文摘 | Carrie Masia-Warner Rachel G Klein Heather C Dent | 2005 | Journal of Abnormal Child Psychology2005，33，6： | 1 |
| 4 | The possible role of the kynurenine pathway in adolescent depression with melancholic features显示文摘 | Vilma Gabbay Rachel G Klein Y Katz | 2010 | Child Psychology Psychiatry2010，51，8： | 1 |
| 5 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | Rachel W Li G David Lin Stephen P Myers David N Leach | 2002 | Journal of Ethnopharmacology2002，，1： | 1 |
| 6 | A study of amber and copal samples using FT-Ramanspeetroscopy显示文摘 | Rachel H Brody Howell G M Edwards | 2001 | Spectrochimica Acta Part A2001，，57： | 1 |
| 7 | Molecular analysis of the rfb O antigen gene cluster of Salmonella enterica serogroup O: 6, 14 and development of a sero-group-specific PCR assay显示文摘 | Collette F Rachel S Linda L G | 2003 | Applied and Environmental Microbiology2003，69，10： | 1 |
| 8 | Changes in the intra- metropolitan loca- tion of producer services in the France (1978--1997) : Do informa- tion technologies promote a more dispersed spatial pattern? 显示文摘 | ORAIN C B RACHEl G | 2004 | Ur- ban Geography2004，25，6： | 1 |
| 9 | Immunostimulalory function of herpes simplex virus isolates from patients with frequent herpes labialis and a deficiency in immunespecific interferon production显示文摘 | Rachel LK Jon A G Spotswood LS | 2005 | Journal of Medical Virology2005，16，3： | 1 |
| 10 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland显示文摘 | Katrina E G Bert B Rachel S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 11 | A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland 显示文摘 | KATRINA E G BERT B RACHEL S C | 2000 | Breast Cancer Res2000，2，3： | 1 |
| 12 | Adoption of Environmental Innova- tions: Analysis from the Waipara Wine Industry 显示文摘 | Sharon L F Ross C Rachel G | 2013 | Wine Economies and Policy2013，2，1： | 1 |
| 13 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | LI RACHEL W DAVID LIN G MYERS STEPLEN P | 2003 | J E thnopharmacol2003，85，1： | 1 |
| 14 | Soluble methionine enhances accumulation of a 15 kDa zein, a methionine- rich storage protein, in transgenic alfalfa but not in transgenic tobacco plants 显示文摘 | Amira G Ifat M Tal A Hana B Shmuel Rachel A | 2005 | Journal of Experimental Botany2005，56，419： | 1 |
| 15 | Appropriate bodymass index and waist circumference cutoffs for categorizationof overweight and central adiposity among Chinese adults显示文摘 | Rachel PW Dongfeng G Kristi R | 2004 | Am J Clin Nutr2004，80，5： | 1 |
| 16 | Prevalence of Physical Activity Among Chinese Adults : Results From the International Collaborative Study of Cardiovascular Disease in Asia 显示文摘 | PAUL M DONFENG G RACHEL P W | 2005 | American Journal of Public Health2005，95，9： | 1 |
| 17 | Personal involvement as a determinant of argument-based persuasion 显示文摘 | Petty R E John T C Rachel G | 1981 | Journal of Personality and Social Psychology1981，41，5： | 1 |
| 18 | Anti-inflamma- tory activity of Chinese medicinal vine plants 显示文摘 | Rachel WL G David L Stephen PM | 2003 | J Ethnopharmacol2003，85，1： | 1 |
| 19 | Interleukin 10 protects mice against staphylococcal enterotoxin B-induced lethal shock显示文摘 | ANDREW G D RACHEL A SYLVIA A | 1993 | Infection and Immunity1993，61，11： | 1 |
| 20 | A comparison of tourists in Koh Phi Phi, Thailand and Gili Trawangan, Indonesia 显示文摘 | Rachel D Sonya R G Mark H | 2010 | Journal of Sustainable Tourism2010，22，3： | 1 |
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