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| 1 | Tissue differential expression of lycopene β-cyclase gene in papaya显示文摘Carotene pigments in flowers and fruits are distinct features related to fitness advantages such as attracting insects forpollination and birds for seed dispersal.In papaya,the flesh color of the fruit is considered a quality trait that correlateswith nutritional value and is linked to shelf-life of the fruit.To elucidate the carotenoid biosynthesis pathway in papaya,we took a candidate gene approach to clone the lycopene β-cyclase gene,LCY-B.A papaya LCY-B ortholog,cpLCY-B,was successfully identified from both cDNA and bacterial artificial chromosome(BAC)libraries and complete genomicsequence was obtained from the positive BAC including the promoter region.This cpLCY-B shared 80% amino acididentity with citrus LCY-B.However,full genomic sequences from both yellow- and red-fleshed papaya were identical.Quantitative real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth yellow-and red-fleshed genotypes.Further expression analyses of cpLCY-B showed that its expression levels wereseven- and three-fold higher in leaves and,respectively,flowers than in fruits,suggesting that cpLCY-B is down-regulatedduring the fruit ripening process. | Rachel L Skelton Qingyi Yu Rajeswari Srinivasan Richard Manshardt Paul H Moore Ray Ming | 2006 | Cell Research2006，16，8： | 8 |
| 2 | Emission analysis of alternative diesel fuels using a compression ignition benchtop engine generator显示文摘 | GREGORY S B RACHEL L M MICHAEL P H | 2011 | Energy & Fuels2011，25，： | 1 |
| 3 | Antisense inhibition of the NR Gene restores norml ripening to the tomato Never- ripe mutant consistent with the ethylene receptor- inhibition model 显示文摘 | Rachel M H Chin - Wen Ho Zhefeng L | 2000 | Plant Physiol2000，，10： | 1 |
| 4 | Control of pollen tube tip growth by a Rop GTPase dependent pathway that leads to tip localized calcium influx显示文摘 | Hal L Yakang L Rachel H Michael Z | 1999 | Plant Cell1999，11，： | 1 |
| 5 | Sodium nitrate particles: physical and chemical properties during hydration and dehydration, and implications for aged sea salt aerosols显示文摘 | Rachel H Alexander L Barbara F | 2004 | Aerosol Science2004，，： | 1 |
| 6 | Barley arabinoxylan arabinofnranohydrolases : purification , characterization and determination of primary structures from cDNA clones 显示文摘 | Robert C L Rachel A B Maria H | 2001 | Biochemical Journal2001，356，： | 1 |
| 7 | The Carotenoids β-carotene, Canthaxanthin and Zeaxanthin Inhibit Macrophage-mediated LDL Oxidation显示文摘 | Keri L H Carpenter Carina Van Der Veen Rachel Hird | 1996 | Federation of European Biochemical Societies1996，，401： | 1 |
| 8 | Modulation ofNonspecific Binding in Ultrafiltration Protein BindingStudies 显示文摘 | Kyoung-Jin L Rachel M Tom H | 2003 | Pharmaceutical Research2003，20，7： | 1 |
| 9 | Effect of 5'-regulatory region polymorphism on paraoxonase gene (PON) expression显示文摘 | Victoria H Rachel L James B | 2001 | Am J Hum Genet2001，68，： | 1 |
| 10 | Protein, lipid, and DNA radicals to measure skin UVA damage and modulation by melanin显示文摘 | RACHEL H FABRICE R MARTIN L | 2008 | Free Radical Biology and Medicine2008，44，6： | 1 |
| 11 | Type 2 diabetes, glucose homeostasis and incident atrial fibrillation: the atherosclerosis risk in communities study 显示文摘 | Rachel H Alvaro A Faye L | 2012 | Heart2012，98，2： | 1 |
| 12 | Hematopoietic colony-forming cells derived from human embryonic stem cells显示文摘 | Dan S K Eric T H Rachel L L | 2001 | Proc Natl Acad Sci2001，98，10： | 1 |
| 13 | Nitroaromatic explo- sive sorption and sensing using electrochemically processed polyaniline-titanium dioxide hybrid nanocomposite显示文摘 | Yong X G Rachel H Y James L | 2014 | Mater Chem Phys2014，143，3： | 1 |
| 14 | Application of Immunological Methods to Differetiate Between Foam-Positive and Haze-Active Proteins Originating from Malt显示文摘 | Evans D Evan Tolhurst Rachel L Robinson Louisem H | 2003 | J Am Soc Brew Chem2003，61，2： | 1 |
| 15 | Coffee, decaffeinated coffee, and tea consumption in relation to incident type 2 diabetes mellitus 显示文摘 | Rachel H Crystal L Federica B | 2009 | Arch Intern Med2009，169，22： | 1 |
| 16 | Cardiogenicity and regenerative potential of cardiac-derived stem cells isolated from adult human and porcine endomyocardial biopsy specimens显示文摘 | Rachel R S Baffle L Cho H C etal | 2006 | Circulation2006，114，： | 1 |
| 17 | Oxidation of chlorinated ethenes by heat-activated persulfate:kinetics and products显示文摘 | Rachel H Waldemer Paul G Tratnyek Richard L Johnson | 2007 | Environmental Science&Technology2007，41，3： | 1 |
| 18 | Constituents of cinnamon inhibit bacterial acetyl coa carboxylase显示文摘 | Glen Jr M Rachel L H Grover L W | 2010 | Planta Med2010，76，： | 1 |
| 19 | Emotional and behavioral adjustment in children born prematurely 显示文摘 | Rachel L S Gili E Dov H E | 2010 | Pediatric2010，7，7： | 1 |
| 20 | Supply and quality of colonoscopy according to the characteristics of gastroenterologists in the French population-based colorectalcancer screening program显示文摘BACKGROUND Since its complete roll-out in 2009,the French colorectal cancer screening program(CRCSP)experienced 3 major constraints[use of a less efficient Guaiac-test(gFOBT),stopping the supply of Fecal-Immunochemical-Test kits(FIT),and suspension of the program due to the coronavirus disease 2019(COVID-19)]affecting its effectiveness.AIM To describe the impact of the constraints in terms of changes in the quality of screeningcolonoscopy(Quali-Colo).METHODS This retrospective cohort study included screening-colonoscopies performed by gastroenterologists between Jan-2010 and Dec-2020 in people aged 50-74 living in Ile-de-France(France).The changes in Quali-colo(Proportion of colonoscopies performed beyond 7 mo(Colo_7 mo),Frequency of serious adverse events(SAE)and Colonoscopy detection rate)were described in a cohort of Gastroenterologists who performed at least one colonoscopy over each of the four periods defined according to the chronology of the constraints[gFOBT:Normal progress of the CRCSP using gFOBT(2010-2014);FIT:Normal progress of the CRCSP using FIT(2015-2018);STOP-FIT:Year(2019)during which the CRCSP experienced the cessation of the supply of test kits;COVID:Program suspension due to the COVID-19 health crisis(2020)].The link between each dependent variable(Colo_7 mo;SAE occurrence,neoplasm detection rate)and the predictive factors was analyzed in a two-level multivariate hierarchical model.RESULTS The 533 gastroenterologists(cohort)achieved 21509 screening colonoscopies over gFOBT period,38352 over FIT,7342 over STOP-FIT and 7995 over COVID period.The frequency of SAE did not change between periods(gFOBT:0.3%;FIT:0.3%;STOP-FIT:0.3%;and COVID:0.2%;P=0.10).The risk of Colo_7 mo doubled between FIT[adjusted odds ratio(aOR):1.2(1.1;1.2)]and STOPFIT[aOR:2.4(2.1;2.6)];then,decreased by 40%between STOP-FIT and COVID[aOR:2.0(1.8;2.2)].Regardless of the period,this Colo_7 mo’s risk was twice as high for screening colonoscopy performed in a public hospital[aOR:2.1(1.3;3.6)]compared to screening-colonoscopy performed in a private clinic.The neoplasm detection,which increased by 60%between gFOBT and FIT[aOR:1.6(1.5;1.7)],decreased by 40%between FIT and COVID[aOR:1.1(1.0;1.3)].CONCLUSION The constraints likely affected the time-to-colonoscopy as well as the colonoscopy detection rate without impacting the SAE’s occurrence,highlighting the need for a respectable reference time-tocolonoscopy in CRCSP. | AkoïKoïvogui Catherine Vincelet Gaëlle Abihsera Hamou Ait-Hadad Hélène Delattre Tu Le Trung Agnès Bernoux Rachel Carroll Jérôme Nicolet | 2023 | World Journal of Gastroenterology2023，29，9： | 0 |
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