| 1 | A scientific perspective of how and why Omicron is less severe than SARS-CoV-2显示文摘Omicron is currently the dominant variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the coronavirus responsible for the coronavirus disease 2019(COVID-19)pandemic.Omicron is associated with mild symptoms,although it can cause harmful effects in high-risk patient populations.Omicron and COVID-19 affect multiple organ systems,including the respiratory system,gastrointestinal tract,cardiovascular system,central nervous system,ophthalmic system,genitourinary tract,and musculoskeletal system.COVID-19 infects additional organ systems,including the hematological system,hepatobiliary system,renal system,and dermatologic system.The viral-induced complications were compared to discuss the effects of Omicron versus the authentic SARS-CoV-2 virus,revealing less detrimental outcomes for Omicron.Moreover,COVID-19 is more likely to infect older adults,males,and obesity with mild to severe symptoms.Omicron causes mild symptoms in younger populations and overweight females.Data were acquired using PubMed,Centers for Disease Prevention and Control,and the World Health Organization.COVID-19 and Omicron mechanisms causing organ system-related complications are likely because of the natural immune response to the active infection,the uncontrollable release of cytokines causing cytokine release syndrome,and direct viral damage through angiotensin-converting enzyme 2/transmembrane serine protease 2 receptor binding and entrance to the host cell for infection. | Rachel Parise Sindhu Ramesh Jun Ren Manoj Y.Govindarajulu Rishi M.Nadar Suhrud Pathak Timothy Moore Muralikrishnana Dhanasekaran | 2023 | Emergency and Critical Care Medicine2023，3，3： | 0 |
| 2 | Health influence of SARS-CoV-2(COVID-19)on cancer:a review显示文摘The novel coronavirus,namely,SARS-CoV-2(COVID-19),broke out two years ago and has caused major global health issues.Adequate treatment options are still lacking for the management of COVID-19 viral infections.Many patients afflicted with COVID-19 may range from asymptomatic to severe symptomatic,triggering poor clinical outcomes,morbidity,and mortality.Cancer is one of the leading causes of death worldwide.It is pertinent to re-examine cancer prevalence during the COVID-19 pandemic to prevent mortality and complications.Understanding the impact of SARS-CoV-2 on cancer is key to appropriate healthcare measures for the treatment and prevention of this vulnerable population.Data was acquired from PubMed using key search terms.Additional databases were utilized,such as the Centers for Disease Prevention and Control,American Cancer Society(ACS),and National Cancer Institute(NCI).Cancer patients are more prone to SARS-CoV-2 infection and exhibit poor health outcomes,possibly due to a chronic immunosuppressive state and anticancer therapies.Male sex,older age,and active cancer disease or previous cancer are risk factors for COVID-19 infection,leading to possible severe complications,including morbidity or mortality.The speculated mechanism for potentially higher mortality or COVID-19 complications is through reduced immune system function and inflammatory processes through cancer disease,anticancer therapy,and active COVID-19 infection.This review includes prostate,breast,ovarian,hematologic,lung,colorectal,esophageal,bladder,pancreatic,cervical,and head and neck cancers.This review should help better maintain the health of cancer patients and direct clinicians for COVID-19 prevention to improve the overall health outcomes. | Rachel Parise Yiran ELi Rishi MNadar Sindhu Ramesh Jun Ren Manoj Yogish Govindarajulu Timothy Moore Muralikrishnan Dhanasekaran | 2022 | Acta Biochimica et Biophysica Sinica2022，54，10： | 0 |
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