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| 1 | Review of the treatment of liver hydatid cysts显示文摘A review was carried out in Medline,LILACS and the Cochrane Library.Our database search strategy included the following terms: 'hydatid cyst','liver','management','meta-analysis' and 'randomized controlled trial'.No language limits were used in the literature search.The latest electronic search date was the 7th of January 2014.Inclusion and exclusion criteria: all relevant studies on the assessment of therapeutic methods for hydatid cysts of the liver were considered for analysis.Information from editorials,letters to publishers,low quality review articles and studies done on animals were excluded from analysis.Additionally,well-structured abstracts from relevant articles were selected and accepted for analysis.Standardized forms were designed for data extraction; two investigators entered the data on patient demographics,methodology,recurrence of HC,mean cyst size and number of cysts per group.Four hundred and fourteen articles were identified using the previously described search strategy.After applying the inclusion and exclusion criteria detailed above,57 articles were selected for final analysis: one meta-analysis,9 randomized clinical trials,5 non-randomized comparative prospective studies,7 non-comparative prospective studies,and 34 retrospective studies(12 comparative and 22 noncomparative).Our results indicate that antihelminthic treatment alone is not the ideal treatment for liver hydatid cysts.More studies in the literature support the effectiveness of radical treatment compared with conservative treatment.Conservative surgery with omentoplasty is effective in preventing postoperative complications.A laparoscopic approach is safe in some situations.Percutaneous drainage with albendazole therapy is a safe and effective alternative treatment for hydatid cysts of the liver.Radical surgery with preand post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates. | Concepción Gomez i Gavara Rafael López-Andújar Tatiana Belda Ibáez José M Ramia ngel ngel Moya Herraiz Francisco Orbis Castellanos Eugenia Pareja Ibars Fernando San Juan Rodríguez | 2015 | World Journal of Gastroenterology2015，21，1： | 8 |
| 2 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 3 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 4 | Cloning the cDNA for a new human zinc finger protein defines a group of closely related Kruppel-like transcription factors显示文摘 | Nobukyuki M Friedrich L Rafael A | 1998 | The Journal of Biological Chemistry1998，273，28： | 1 |
| 5 | Antibiotics and an- tibiotic resistance in water environments 显示文摘 | Femando B Jose L M Rafael C | 2008 | Current opinion in biotechnology2008，19，3： | 1 |
| 6 | Effect of simultane-ous down-regulation of pectate lyase and endo-(3-l,4-glucanasegenes on strawberry fruit softening显示文摘 | YOUSSEF S M IRAIDA A L^PEZ-ARANDA J M’ RAFAELS VICTORIANO V GIORGIO C ROSARIO B-P FERNAN-DO P-A OUESADA M A MERCADO J A | 2013 | Molecular Breeding2013，31，： | 1 |
| 7 | Generation maintenance scheduling considering transmission constraints显示文摘 | da Silva E L Th Schilling M Rafael M C | 2000 | IEEE Trans on Power Systems2000，15，2： | 1 |
| 8 | Synthesis of photo- andelectroactive stilbenoid dendrimers carrying dibutylamino peripheral groups显示文摘 | Jose L S Rafael G Nazario M | 2001 | Organic Letters2001，3，17： | 1 |
| 9 | Agricultural use of three (sugar-beet) vinasse composts: effect on crops and chemical properties of a Cambisol soil in the Guadalquivir river valley (SW Spain)显示文摘 | Engracia Madejón Rafael López José M Murillo Francisco Cabrera | 2001 | Agriculture Ecosystems and Environment2001，，1： | 1 |
| 10 | River channelizatione effects on fish population structure in the Larraun river (Northern Spain)显示文摘 | JAVIER O PEDROM L RAFAEL M | 2005 | Hydrobiologia2005，543，： | 1 |
| 11 | Micronucleus induction in erythrocytes of the hyla pulchella tadpoles (amphibia hylidae) exposed to insecticide endosulfan显示文摘 | Rafael C L Mariana C Paola M | 2005 | Mutation Research2005，587，： | 1 |
| 12 | Al-tematives for treatment and disposal cost reduction of regulated medical wastes显示文摘 | Byeong K L Michael J E Rafael M E | 2004 | Waste Management2004，24，： | 1 |
| 13 | A dynamic panel data model显示文摘 | Belen R Rafael L M Asun G Effect of low-cost airlines on tourism in spain | 2011 | Journal of Air Transport Management2011，，17： | 1 |
| 14 | Determination of tea components with antioxidant activity 显示文摘 | RAFAEL C C GIMENEZ M C L | 2003 | Agric Food Chem2003，51，： | 1 |
| 15 | A Kinematic Model of Infiltration and Runoff Generation in Layered and Sloped Soils显示文摘 | Cabral M C Garrote L Rafael L B | 1992 | Advances in Water Resources1992，，15： | 1 |
| 16 | Er-doped ZnO thin films grown by pulsed-laser deposition 显示文摘 | RAFAEL P C ARACELI G L OLIVIER P Y M | 2005 | J Appl Phys2005，97，5： | 1 |
| 17 | Developmental changes of functional and directed resting-state connectivities associated with neuronal oscillations in EEG显示文摘 | Lars M Muthuraman M Rafael L | 2013 | NeuroImage2013，81，： | 1 |
| 18 | A human-robot cooperative learning system for easy installation of assistant robots in new working environments显示文摘 | Elena L M Rafael B B L Miguel | 2004 | Journal of Intelligent and Robotic Systems2004，40，3： | 1 |
| 19 | Global uncertainty and sensitivity analysis of a spatially distributed ecological mod- el 显示文摘 | GARETH L GREGORY K RAFAEL M | 2014 | Ecological Modelling2014，275，： | 1 |
| 20 | Applications of ionic liquids in the removal of contaminants from refinery feedstocks:an industrial perspective 显示文摘 | Rafael M P Rafael L | 2014 | Energy & Environmental Science2014，7，： | 1 |
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