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| 1 | Neoadjuvant-intensified treatment for rectal cancer:Time to change?显示文摘AIM:To investigate whether neoadjuvant-intensified radiochemotherapy improved overall and disease-free survival in patients with locally advanced rectal cancer.METHODS:Between January 2007 and December 2011,80 patients with histologically confirmed rectal adenocarcinoma were enrolled.Tumors were clinically classified as either T3 or T4 and by the N stage based on the presence or absence of positive regional lymph nodes.Patients received intensified combined modality treatment,consisting of neoadjuvant radiation therapy(50.4-54.0 Gy) and infusional chemotherapy(oxaliplatin 50 mg/m 2) on the first day of each week,plus five daily continuous infusions of fluorouracil(200 mg/m 2 per die) from the first day of radiation therapy until radiotherapy completion.Patients received five or six cycles of oxaliplatin based on performance status,clinical lymph node involvement,and potential risk of a non-sphincter-conserving surgical procedure.Surgery was planned 7 to 9 wk after the end of radiochemotherapy treatment;adjuvant chemotherapy treatment was left to the oncologist's discretion and was recommended in patients with positive lymph nodes.After treatment,all patients were monitored every three months for the first year and every six months for the subsequent years.RESULTS:Of the 80 patients enrolled,75 patients completed the programmed neoadjuvant radiochemotherapy treatment.All patients received the radiotherapy prescribed total dose;five patients suspended chemotherapy indefinitely because of chemotherapyrelated toxicity.At least five cycles of oxaliplatin were administered to 73 patients.Treatment was well tolerated with high compliance and a good level of toxicity.Most of the acute toxic effects observed were classified as grades 1-2.Proctitis grade 2 was the most common symptom(63.75%) and the earliest manifestation of acute toxicity.Acute toxicity grades 3-4 was reported in 30% of patients and grade 3 or 4 diarrhoea reported in just three patients(3.75%).Seventy-seven patients underwent surgery;low anterior resection was performed in 52 patients,Miles' surgery in 11 patients and total mesorectal excision in nine patients.Fifty patients showed tumor downsizing ≥ 50% pathological downstaging in 88.00% of tumors.Out of 75 patients surviving surgery,67 patients(89.33%) had some form of downstaging after preoperative treatment.A pathological complete response was achieved in 23.75% of patients and a nearly pathologic complete response(stage ypT1ypN0) in six patients.An involvement of the radial margin was never present.During surgery,intra-abdominal metastases were found in only one patient(1.25%).Initially,45 patients required an abdominoperineal resection due to a tumor distal margin ≤ 5 cm from the anal verge.Of these patients,only seven of them underwent Miles' surgery and sphincter preservation was guaranteed in 84.50% of patients in this subgroup.Fourteen patients received postoperative chemotherapy.In the full analysis of enrolled cohort,eight of the 80 patients died,with seven deaths related to rectal cancer and one to unrelated causes.Local recurrences were observed in seven patients(8.75%) and distant metastases in 17 cases(21.25%).The fiveyear rate of overall survival rate was 90.91%.Using a median follow-up time of 28.5 mo,the cumulative incidence of local recurrences was 8.75%,and the overall survival and disease-free survival rates were 90.00% and 70.00%,respectively.CONCLUSION:The results of this study suggest oxaliplatin chemotherapy has a beneficial effect on overall survival,likely due to an increase in local tumor control. | Daniela Musio Francesca De Felice Nadia Bulzonetti Roberta Guarnaccia Rossella Caiazzo Caterina Bangrazi Nicola Raffetto Vincenzo Tombolini | 2013 | World Journal of Gastroenterology2013，19，20： | 5 |
| 2 | Chemoradiation as definitive treatment for primary squamous cell cancer of the rectum显示文摘In this report,we present a case of advanced squamous cell cancer located in the rectum of a 78-year-old woman treated with chemoradiation with curative intent.The patient showed a complete clinical response to chemoradiation;multiple biopsies were performed at the site of the previous mass 5 mo after the end of treatment and histological examination showed no residual tumour in the specimens.Surgical intervention was avoided and the patient was free of disease 12 mo after the diagnosis of cancer.Primary chemoradiation should be considered as the treatment of choice for this rare malignancy. | Eva Iannacone Francesco Dionisi Daniela Musio Rossella Caiazzo Nicola Raffetto Enzo Banelli | 2010 | World Journal of Radiology2010，2，8： | 2 |
| 3 | Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease显示文摘 | Joseph D. Raffetto Raouf A. Khalil | 2007 | Biochemical Pharmacology2007，，2： | 2 |
| 4 | Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease 显示文摘 | Raffetto JD Khalil RA | 2008 | Biochem Pharmacol2008，75，2： | 1 |
| 5 | TRUS staging and follow-up in patients with anal canal cancer显示文摘 | Drudi FM Raffetto N De Rubeis M | 2003 | Radiol Med(Torino)2003，106，4： | 1 |
| 6 | Matrix Metalloproteinases and their inhibitors in vascular remodeling and vascular disease显示文摘 | Joseph D Raffetto Raouf A Kbalil | 2008 | Biochem Pharmaco2008，75，2： | 1 |
| 7 | Electromagnetic scattering by a multilayer elliptic cylinder under transverse-magnetic illumination: Series solution in terms of Mathieu functions 显示文摘 | Caorsi S Pastorino M Raffetto M | 1997 | IEEE Trans Antennas Propagat1997，45，6： | 1 |
| 8 | Dermal pathology, cellular biology, and inflammation in chronic venous disease显示文摘 | Raffetto JD | 2009 | Thromb Res2009，123，4： | 1 |
| 9 | Matrix metallop mteinases andtheir in- hibitors in vascular remodeling and vascular disease显示文摘 | Joseph D Raffetto Raouf A | 2008 | Biochem Phar- macol2008，75，2： | 1 |
| 10 | Matrix metalloproteinases and their inhibitors in vascular remodeling and vasculardisease显示文摘 | Raffetto J D Khalil R A | | 0，，2： | 1 |
| 11 | Mechanisms of varicose vein formation: valve dysfunction and wall dilation显示文摘 | Raffetto JD Khalil RA | 2008 | Phlebology2008，23，2： | 1 |
| 12 | Matrix metalloproteinase and their in-hibitors in Vascular Remodeling and vascular disease显示文摘 | RAFFETTO J KHALIL R | 2008 | Biochem Pharmacol2008，75，2： | 1 |
| 13 | Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease显示文摘 | Joseph D Raffetto MD Raouf A | 2008 | Bio-chem Pharmacol2008，75，2： | 1 |
| 14 | An in-verse scattering approach based on a neural networktechnique for the detection of dielectric cylinders buriedin a lossy half~space显示文摘 | BERMANI E CAORSI S RAFFETTO M | 2000 | PIER2000，26，4： | 1 |
| 15 | Synopsis on cellular senescence and apoptosis显示文摘 | RAFFETTO J D LEVERKUS M PARK H Y | 2001 | J Vasc Surg2001，34，1： | 1 |
| 16 | Matrix metalloproteinase and their inhibitors in vascular remodeling and vascular disease显示文摘 | Raffetto J Khalil R | 2008 | Biochem Pharmacol2008，75，2： | 1 |
| 17 | Micro-wave detection and dielectric characterization of cylin-drical objects from amplitude-only data by means ofneural networks 显示文摘 | BERMANI E CAORSI S RAFFETTO M | 2002 | IEEE Trans Antennas Propag2002，50，9： | 1 |
| 18 | Managing soft tissue using a laser:a 5-year retrospective显示文摘 | GUTIERREZ T RAFFETTO N | 1999 | Dent Today1999，18，： | 1 |
| 19 | Matrix metalloprotein-ase 2-induced venous dilation via hyperpolarization and ac-tivation of K + channels:relevance to varicose vein forma-tion显示文摘 | Raffetto JD Ross RL Khalil RA | | 0，，2： | 1 |
| 20 | Geomet-ric and dielectric characterization of buried cylinders byusing simple time-domain electromagnetic data and neu-ral networks显示文摘 | BERMANI E CAORSI S RAFFETTO M | 2000 | Microwave Opt Technol Lett2000，24，1： | 1 |
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