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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Choledochal cyst 显示文摘 | GAFUR MA RAHMAN ME | 2007 | Mymensingh Med J2007，16，： | 1 |
| 3 | Antibody seroprevalences against Peste des Petits Ruminants (PPR) virus in sheep and goats in Sudan显示文摘 | Osman NA Ali AS A/Rahman ME | 2009 | Trop Anim Health Prod2009，41，7： | 1 |
| 4 | Antibody seroprevalences against Peste des petits ruminants (PPR) virus in sheep and goats in Sudan显示文摘 | Osman NA All AS A/Rahman ME | 2009 | Trop Anita Health Prod2009，41，7： | 1 |
| 5 | The Brd4 extraterminal domain confers transcription activation independent of p TEFb by recruiting multiple proteins,including NSD3显示文摘 | Rahman S Sowa ME Ottinger M | 2011 | Mol Cell Biol2011，31，13： | 1 |
| 6 | Montreal Cognitive Assessment Arabic version:Reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo显示文摘 | Rahman TA Gaafary ME | 2009 | Geriatr Gerontol Int2009，9，1： | 1 |
| 7 | Ventral free oral mucous membrane graft for bulbar urethral stricture显示文摘 | Haque ME Rahman MA Islam MF | | 0，，04： | 1 |
| 8 | Optimizing inventory decisions in a multi-stage supply chain under stochastic demands显示文摘 | ME Seliaman Ab Rahman Ahmad | 2008 | Applied Mathematics and Computation2008，206，2： | 1 |
| 9 | Efficacy of azithromycin in the treatment of childhood typhoid Fever显示文摘 | Islam MN Rahman ME Rouf MA | 2007 | Mymensingh Med J2007，16，2： | 1 |
| 10 | Problem based leaming显示文摘 | Rahman ME Perveen R Chowhury AM | 2003 | Mymensingh Med J2003，12，1： | 1 |
| 11 | Effects of C/N ratio and substrate addition on natural food communities in freshwater prawn monoculture ponds显示文摘 | Asaduzzaman M Rahman MM Azim ME | 2010 | Aquaculture2010，306，14： | 1 |
| 12 | Problem-based learning显示文摘 | RAHMAN ME PERVEEN R CHOWHURY AM | 2003 | Mymensingh Med J2003，12，1： | 1 |
| 13 | E-octadec-7-en-5ynoic acid from the roots of Capparis zeylanica显示文摘 | Haque M Rahman MM | 2004 | Fitoterapia2004，75，2： | 1 |
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