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| 1 | High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells显示文摘AIM: To analyze the relevance of the microRNA miR-196a for colorectal oncogenesis. METHODS: The impact of miR-196a on the restriction targets HoxA7, HoxB8, HoxC8 and HoxD8 was analyzed by reverse transcription polymerase chain reaction (RT-PCR) after transient transfection of SW480 cancer cells. The miR-196a transcription profile in colorectal cancer samples, mucosa samples and diverse cancer cell lines was quantifi ed by RT-PCR. Transiently miR-196a-transfected colorectal cancer cells were used for diverse functional assays in vitro and for a xenograft lung metastasis model in vivo. RESULTS: HoxA7, HoxB8, HoxC8 and HoxD8 were restricted by miR-196a in a dose-dependent and gene-specific manner. High levels of miR-196a activated the AKT signaling pathway as indicated by increased phosphorylation of AKT. In addition, high levels of miR-196a promoted cancer cell detachment,migration, invasion and chemosensitivity towards platin derivatives but did not impact on proliferation or apoptosis. Furthermore, miR-196a increased the development of lung metastases in mice after tail vein injection. CONCLUSION: miR-196a exerts a pro-oncogenic influence in colorectal cancer. | Carl Christoph Schimanski Kirsten Frerichs Fareed Rahman Martin Berger Hauke Lang Peter R Galle Markus Moehler Ines Gockel | 2009 | World Journal of Gastroenterology2009，15，17： | 40 |
| 2 | Early acute kidney injury after liver transplantation: Predisposing factors and clinical implications显示文摘AIM To investigate the additional clinical impact of hepatic ischaemia reperfusion injury(HIRI) on patients sustaining acute kidney injury(AKI) following liver transplantation.METHODS This was a single-centre retrospective study of consecutive adult patients undergoing orthotopic liver transplantation(OLT) between January 2013 and June 2014. Early AKI was identified by measuring serum creatinine at 24 h post OLT(> 1.5 × baseline) or by the use of continuous veno-venous haemofiltration(CVVHF) during the early post-operative period. Patients with and without AKI were compared to identify risk factors associated with this complication. Peak serum aspartate aminotransferase(AST) within 24 h post-OLT was used as a surrogate marker for HIRI and severity was classified as minor(< 1000 IU/L), moderate(1000-5000 IU/L) or severe(> 5000 IU/L). The impact on time to extubation, intensive care length of stay, incidence of chronic renal failure and 90-d mortality were examined firstly for each of the two complications(AKI and HIRI) alone and then as a combined outcome. RESULTS Out of the 116 patients included in the study, 50% developed AKI, 24% required CVVHF and 70% sustainedmoderate or severe HIRI. Median peak AST levels were 1248 IU/L and 2059 IU/L in the No AKI and AKI groups respectively(P = 0.0003). Furthermore, peak serum AST was the only consistent predictor of AKI on multivariate analysis P = 0.02. AKI and HIRI were individually associated with a longer time to extubation, increased length of intensive care unit stay and reduced survival. However, the patients who sustained both AKI and moderate or severe HIRI had a longer median time to extubation(P < 0.001) and intensive care length of stay(P = 0.001) than those with either complication alone. Ninety-day survival in the group sustaining both AKI and moderate or severe HIRI was 89%, compared to 100% in the groups with either or neither complication(P = 0.049). CONCLUSION HIRI has an important role in the development of AKI post-OLT and has a negative impact on patient outcomes, especially when occurring alongside AKI. | Suehana Rahman Susan V Mallett Brian R Davidson | 2017 | World Journal of Hepatology2017，9，18： | 6 |
| 3 | Loss of p27 nuclear expression in a prognostically favorable subset of well-differentiated pancreatic neoplasms 显示文摘 | Rahman A Maitra A Ashfaq R | 2003 | Am J Clin pathol2003，120，5： | 2 |
| 4 | An expert system based algorithm for short term load forecast显示文摘 | Rahman S Bhatnagar R | 1988 | IEEE Trans on Power Systems1988，3，2： | 2 |
| 5 | DynamicYoung's modulus and dimensional stability of Batai tropical wood impregnated with polyvinyl alcohol显示文摘 | ISLAM M S HAMDAN S RAHMAN M R | 2010 | Journal of Scientific Research2010，2，2： | 1 |
| 6 | A decision support technique for the design of hybrid solar-wind power systems显示文摘 | Chedid R Akiki H Rahman S | 1998 | IEEE Trans on Energy Conversion1998，13，1： | 1 |
| 7 | Early surgery for epiretinal membrane preserves more vision for patients显示文摘 | Rahman R Stephenson J | 2014 | Eye(Lond)2014，28，： | 1 |
| 8 | Cerebral hypoxia- ischemia and middle cerebral artery occlusion induce expres- sion of the cannabinoid CB2 receptor in the brain显示文摘 | Ashton J C Rahman R M Nair S M | 2007 | Neuros- ci Lett2007，412，2： | 1 |
| 9 | Replica Placement strategiesin data grid显示文摘 | Rahman R M Barker K Alhajj R | 2008 | Journal of Grid Computing2008，6，1： | 1 |
| 10 | Effects of C / N ratio and periphyton substrates on pond ecology and production perfor- mance in giant freshwater prawn Macrobrachium rosenbergii ( De Man, 1879 ) and tilapia Oreochromis niloticus ( Linnaeus, 1758 ) polycuhure system 显示文摘 | Haque M R Islam M A Rahman M M | 2013 | Aquacuhure Research2013，，： | 1 |
| 11 | Sulindac and exisulind exhibit a significant antiproliferative effect and induce apoptosis in human hepatocellular carcinoma cell lines 显示文摘 | Dhar DK Masunaga R | 2000 | Cancer Res2000，60，： | 1 |
| 12 | Contrast media-induced lipid peroxidation in the rat kidney显示文摘 | Parvez Z Rahman MA0 Moncada R | 1989 | Invest Radiol1989，24，9： | 1 |
| 13 | Combined penile placation surgery and insertion of penile prosthesis for severe penile curvature and erectile dysfunction显示文摘 | Rahman N U Carrion R E Bochinski D | 2004 | J Urol2004，171，： | 1 |
| 14 | hTERT antagonizes p53-induced apoptosis independently of telomerase activity显示文摘 | Rahman R Latonen L Wiman KG | 2005 | Oncogene2005，24，： | 1 |
| 15 | A novel method to determine tearprism height显示文摘 | Jones L Leech R Rahman S | 2002 | Optom Vis Sci2002，79，25： | 1 |
| 16 | Application of genomics, proteomics and metabolomics in drug discov- ery, development and elinic 显示文摘 | Russell C Rahman A Mohammed A R | 2013 | Ther Deliv2013，4，3： | 1 |
| 17 | Plaeental protein13(galeetin-13)has deereased plaeental expression but inereased shedding and maternal serum concentrations in Patients presenting with preterm preeclampsia and HELLP syndrome显示文摘 | Than N Abdul Rahman O Magenheim R | 2008 | Virehows Arch2008，453，4： | 1 |
| 18 | Severity ofleukoaraiosis correlates with clinical outcome after ischemic stroke显示文摘 | Arsava EM Rahman R Rosand J | | 0，，16： | 1 |
| 19 | The organization of genes tightly linked to the Ha locus in Aegilops tauschii the Dgenome donor to wheat显示文摘 | Turnbull K.M Turner M Mukai Y Yamamoto M Morell M.K Appels R and Rahman S | | 0，，02： | 1 |
| 20 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
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