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| 1 | Cellulose based polymers in development of amorphous solid dispersions显示文摘Cellulose derivatives have gained immense popularity as stabilizers for amorphous solid dispersion owing to their diverse physicochemical properties. More than 20 amorphous solid dispersion-based products that have been approved for marketing consist of cellulose derivatives as stabilizers, thus highlighting their importance in generation of amorphous solid dispersions. These polymers offer numerous advantages like drug solubilization, crystallization inhibition and improvement in release patterns of drugs. Exploring their potential and exploiting their chemistry and p H responsive behaviour have led to the synthesis of new derivatives that has broadened the scope of the use of cellulose derivatives in amorphous formulation development. The present review aims to provide an overview of different mechanisms by which these cellulose derivatives inhibit the crystallization of drugs in the solid state and from supersaturated solution. A summary of different categories of cellulose derivatives along with the newly explored polymers has been provided. A special segment on strengths, weaknesses, opportunities, and threats(SWOT) analysis and critical quality attributes(CQAs) which affect the performance of the cellulose based amorphous solid dispersion will aid the researchers in identifying the major challenges in the development of cellulose based solid dispersion and serve as a guide for further formulation development. | Rahul B Chavan Sneha Rathi Vaskuri G S Sainaga Jyothi Nalini R Shastri | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，3： | 5 |
| 2 | Erythropoietin therapy after out-of-hospital cardiac arrest:A systematic review and meta-analysis显示文摘AIM To assess safety and efficacy of early erythropoietin(Epo) administration in patients with out-of-hospital cardiac arrest(OHCA).METHODS A systematic literature search was performed using PubM ed,MEDLINE,EMBASE,EBSCO,CINAHL,Web of Science and Cochrane databases,of all studies published from the inception through October 10,2016.Inclusion criteria included:(1) Adult humans with OHCA and successful sustained return of spontaneous circulation;and(2) studies including mortality/brain death,acute thrombotic events as their end points.Primary efficacyoutcome was 'brain death or Cerebral Performance Category(CPC) score of 5'.Secondary outcomes were 'CPC score 1,and 2-4','overall thrombotic events' and 'acute coronary stent thrombosis'.RESULTS We analyzed a total of 606 participants(n = 276 received Epo and n = 330 with standard of care alone) who experienced OHCA enrolled in 3 clinical trials.No significant difference was observed between the Epo and no Epo group in brain death or CPC score 5(OR = 0.77;95%CI:0.42-1.39),CPC score 1(OR = 1.16,95%CI:0.82-1.64),and CPC score 2-4(OR = 0.77,95%CI:0.44-1.36).Epo group was associated with increased thrombotic complications(OR = 2.41,95%CI:1.26-4.62) and acute coronary stent thrombosis(OR = 8.16,95%CI:1.39-47.99).No publication bias was observed.CONCLUSION Our study demonstrates no improvement in neurological outcomes and increased incidence of thrombotic events and acute coronary stent thrombosis in OHCA patients who were treated with Epo in addition to standard therapy. | Rahul Chaudhary Jalaj Garg Parasuram Krishnamoorthy Kevin Bliden Neeraj Shah Nayan Agarwal Rahul Gupta Abhishek Sharma Karl B Kern Nainesh C Patel Paul Gurbel | 2017 | World Journal of Cardiology2017，9，12： | 2 |
| 3 | Agreement of Time-Domain and Spectral-Domain Optical Coherence Tomography with Fluorescein Leakage from Choroidal Neovascularization显示文摘 | Rahul N. Khurana Bénédicte Dupas Neil M. Bressler | 2010 | Ophthalmology2010，，7： | 1 |
| 4 | Cervical total disc arthroplast显示文摘 | Rahul B Hood KA | 2012 | Global Spine J2012，2，2： | 1 |
| 5 | Multivariate analysis of relationships between material properties, process parameters and tablet tensile strength for a-lactose m0nohydrates 显示文摘 | Rahul V H Ingunn T Annette B B | 2009 | Eur J Pharm Biopharm2009，73，： | 1 |
| 6 | An Empirical Examination Of VolatiliW Spillover Between the Indian and Us Swap Markets显示文摘 | Vivek B Malhotra D K Philip R Rahul S | 2012 | Intemational Journal of Emerging Markets2012，7，3： | 1 |
| 7 | Exploiting mobility for energy efficient data collection in wireless sensor networks显示文摘 | SUSHANT J RAHUL C S WAYLON B | 2006 | Mobile Networks and Applications2006，11，3： | 1 |
| 8 | Reliability of lead-free copper columns in comparison with tin-lead solder column interconnects显示文摘 | Park S B Joshi Rahul Goldmann Lewis | 2008 | Microelectronics Reliability2008，48，5： | 1 |
| 9 | Human umbilical cord perivascular(HUCPV)cells:a source of mesenchyreal progenitors显示文摘 | Rahul S David L Dolores B | 2005 | Stem Cells2005，23，2： | 1 |
| 10 | An Improved Synthetic Route for the Synthesis of Sulfonamides 显示文摘 | Vasant B Jagrut Rahul A Waghmare Ramrao A Mane | 2011 | International Journal of ChemTech Research2011，3，3： | 1 |
| 11 | New-onset Diabetes: a Potential clue to the early diagnosis of pancreatic cancer I显示文摘 | Rahul P Ananda B Gloria M | 2009 | Lancet Onco12009，10，1： | 1 |
| 12 | Synthon Robustness and Solid-State Architecture in Substituted Gem-Alkynols显示文摘 | Rahul B Raju M Judith A K | 2006 | Crystal Growth & Design2006，6，4： | 1 |
| 13 | Pancreatic lipase inhibitors from natural sources: unexplored potential显示文摘 | Rahul B Birari and Kamlesh K Bhutani | 2007 | Drug Discovery Today2007，12，1920： | 1 |
| 14 | Microsatellite sequences of mammals and their applications in genome analysis in pigs a review显示文摘 | Rahul B N Sheoran J B Tantia M S | 2002 | Asian-Australasian Journal of Animal Sciences2002，15，12： | 1 |
| 15 | Association of vascular endothelial growth factor single nucleotide polymorphisms on the prognosis of breast cancer patients 显示文摘 | Rani J Rahul B Ramesh G | 2014 | Indian J Cancer2014，51，4： | 1 |
| 16 | Control of pore size and functionality in isoreticular zeolitic imidazolate frameworks and their carbon dioxide selective capture properties 显示文摘 | Rahul B Hiroyasu F David B | 2009 | Journals of American Chemical Society2009，131，： | 1 |
| 17 | Integration of oxygen transport membranes in an IGCC power plant with CO2 capture显示文摘 | Rahul A Olav B | 2011 | Chemical Engineering Transactions2011，，25： | 1 |
| 18 | Human umbilical cord perivascular (HUCPV)cells:a source of mesenchymal progenitors显示文摘 | Rahul S David L Dolores B | 2005 | Stem Cells2005，23，22： | 1 |
| 19 | Amicrosatellite(SSR) based linkage map of Brssica rapa显示文摘 | Rahul K Surindar S B Shashi K B | 2009 | New Biotechnol2009，26，5： | 1 |
| 20 | Inadequate investment impacting India's innovation returns-a perspective显示文摘 | KAUSHIK B RAHUL T | 2013 | International Journal of Innovation Science2013，，5： | 1 |
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