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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Discovering functional gene expression patterns in the metabolic network of Escherichia coli with wavelets transforms 显示文摘 | RAINER K GUNNAR S MARCUS O | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 3 | Scientists'Transition to Academic Entrepreneurship显示文摘 | MAXIMILIAN G MART1N O RAINER K S | 2012 | Economic and Psychological Determinants2012，，7： | 1 |
| 4 | Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat显示文摘 | Rainer G Menapace R Findl O | 2003 | J Cataract Refract Surg2003，29，9： | 1 |
| 5 | Comparison of 4 methods for quantifying posterior capsule opacification显示文摘 | Findl O Buehl W Menapace R Georgopoulos M Rainer G Siegl H | 2003 | JCataract Refract Surg2003，29，1： | 1 |
| 6 | Assessment of optic disk blood flow in patients with open-angle glaucoma显示文摘 | Findl O Rainer G Dallinger S | 2000 | Am J Ophthalmol2000，130，5： | 1 |
| 7 | Partial coherence interferometry:a novel approach to biometry in cataract surgery显示文摘 | Drexler W Findl O Menapace R Rainer G Vass C Hitzenberger CK | 1998 | Am J Ophthalmol1998，126，4： | 1 |
| 8 | Bilateral primary adrenal non-Hodgkin's lymphoma and primary adrenocortieal carcinoma-review of the literature preoperative differentiation of adrenal tumors 显示文摘 | Alexanara O Joachim D Rainer L | 2008 | Endocrine Journal2008，55，4： | 1 |
| 9 | Central corneal thickness measurements with partial coherence interferometry, ultrasound, and the Orbscan system 显示文摘 | Rainer G Findl O Petternel V | 2004 | Ophthalmology2004，111，： | 1 |
| 10 | Trust in Software Outsourcing Relationships:An Empirical Investigation of Indian Software Companies显示文摘 | Nilay V O Tracy Hail and Austen Rainer | 2006 | Information and Software Technology2006，，48： | 1 |
| 11 | Species identification of formed fishery products and high pressure-treated fish by electrophoresis:a collaborative study显示文摘 | Monique Etienne Marc Jér(o)me Jo(e)l Fleurence Hartmut Rehbein Rainer Kündiger Rogério Mendes Helena Costa and Iciar Martínez | 2001 | Food Chemistry2001，72，1： | 1 |
| 12 | Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thickness显示文摘 | Rainer G Pettemel V Findl O et ol | 2002 | J Cataract Refract Surg2002，28，： | 1 |
| 13 | Comparison of ultrasound pachymetry and partial coherence interferometry in the measurement of central corneal thickness显示文摘 | Rainer G Petternel V Findl O | 2002 | J Cataract Refract Surg2002，28，12： | 1 |
| 14 | A comparison of data-parallel and message-passing versions of the Miami Isopycnic Coordinate Ocean Model (MICOM)显示文摘 | Rainer Bleck Sumner Dean Matthew O' Keefe | 1995 | Parallel Computing1995，21，10： | 1 |
| 15 | The capsular tension ring: Designs, applications, and techniques 显示文摘 | Menapace R Findl O Georgopoulos M Rainer G Vass C Schmeto terer K | 2000 | J Cataract Refrac Surg2000，26，6： | 1 |
| 16 | Randomised fellow eye comparison of the effectiveness of apraclonidine and acetazolamide on intraocular pressure显示文摘 | Rainer G Menapace R Findl O | 2000 | Eye2000，14，： | 1 |
| 17 | Antioxidant drugs combined with alpha-interferon in chronic hepatitis C not responsive to alpha-interferon alone: a randomized, multicentre study显示文摘 | Gaetano Idéo Antonio Bellobuono Silvana Tempini Luca Mondazzi Aido Airoldi Gianpiero Benetti Franco Bissoli Cristina Cestari Enrico Colombo Paolo Del Poggio Osvaldo Fracassetti Sergio Lazzaroni Achille Marelli Bruno Paris Alberto Prada Enrico Rainer Luigi | 1999 | European Journal of Gastroenterology & Hepatology1999，，11： | 1 |
| 18 | Intraoeular pressure after small incision cataract surgery with Healon5 and Viscoat显示文摘 | Rainer G Menapace R Findl O | 2000 | J Cataract Refract Surg2000，26，2： | 1 |
| 19 | Changes in intraocular lens position after neodymium: YAG capsulotomy显示文摘 | Findl O Drexler W Menapace R Georgopoulos M Rainer G Hitzenberger CK | 1999 | J Cataract Refract Surg1999，25，5： | 1 |
| 20 | MRI Scanning and Incus Fixation in Vibrant Soundbridge Implantation 显示文摘 | Ingo T Rainer O S Sven M | 2004 | Otology & Neurotology2004，25，： | 1 |
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