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| 1 | Neutron-gamma discrimination method based on blind source separation and machine learning显示文摘The discrimination of neutrons from gamma rays in a mixed radiation field is crucial in neutron detection tasks.Several approaches have been proposed to enhance the performance and accuracy of neutron-gamma discrimination.However,their performances are often associated with certain factors,such as experimental requirements and resulting mixed signals.The main purpose of this study is to achieve fast and accurate neutron-gamma discrimination without a priori information on the signal to be analyzed,as well as the experimental setup.Here,a novel method is proposed based on two concepts.The first method exploits the power of nonnegative tensor factorization(NTF)as a blind source separation method to extract the original components from the mixture signals recorded at the output of the stilbene scintillator detector.The second one is based on the principles of support vector machine(SVM)to identify and discriminate these components.In addition to these two main methods,we adopted the Mexican-hat function as a continuous wavelet transform to characterize the components extracted using the NTF model.The resulting scalograms are processed as colored images,which are segmented into two distinct classes using the Otsu thresholding method to extract the features of interest of the neutrons and gamma-ray components from the background noise.We subsequently used principal component analysis to select the most significant of these features wich are used in the training and testing datasets for SVM.Bias-variance analysis is used to optimize the SVM model by finding the optimal level of model complexity with the highest possible generalization performance.In this framework,the obtained results have verified a suitable bias–variance trade-off value.We achieved an operational SVM prediction model for neutron-gamma classification with a high true-positive rate.The accuracy and performance of the SVM based on the NTF was evaluated and validated by comparing it to the charge comparison method via figure of merit.The results indicate that the proposed approach has a superior discrimination quality(figure of merit of 2.20). | Hanan Arahmane El-Mehdi Hamzaoui Yann Ben Maissa Rajaa Cherkaoui El Moursli | 2021 | Nuclear Science and Techniques2021，32，2： | 2 |
| 2 | Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers显示文摘 | Annika Allqvist Jun Miura Leif Bertilsson Rajaa A. Mirghani | 2007 | European Journal of Clinical Pharmacology2007，，2： | 1 |
| 3 | In Vivo Generation of Dental Pulp-like Tissue by Using Dental Pulp Stem Cells,a Collagen Scaffold, and Dentin Matrix Protein 1 after Subcutaneous Transplantation in Mice 显示文摘 | Rebecca SP Rajaa A Mohamed IF | 2008 | J Endod2008，34，4： | 1 |
| 4 | Listeria protein ActA mimics WASP family proteins:It activates filament barbed end branching by Arp2/3 complex显示文摘 | Rajaa Boujemaa-Paterski Edith Gouin Guido Hansen | 2001 | Biochemistry2001，40，11： | 1 |
| 5 | Prevalence of cor- onary risk factors, clinical presentation, and complications in a- cute coronary syndrome patients living at high vs low altitudes in Yemen显示文摘 | A1-Huthi MA Rajaa YA A1-Noami M | 2006 | MedGenMed2006，8，4： | 1 |
| 6 | Biomimetic approach to perforation repair using dental pulp stem cells and dentin matrix protein 显示文摘 | Rajaa A Sriram R Mohamed IF er al | 2011 | J Endodontics2011，37，8： | 1 |
| 7 | Novel tetrabydropyrido isoindolone derivatives ( Valm- erins) :Potent cyelin-dependent kinase/glycogen synthase kinase 3 inhibitors with antiproliferative activities and an- titumor effects in human tumor xenografts 显示文摘 | Rajaa Boulahjar Aziz Ouaeh Chiurato Matteo | 2012 | J Med Chem2012，55，： | 1 |
| 8 | Fault current contribution from synchronous machine and inverter based distributed generators显示文摘 | Natthaphob N Gerald T H RajaA | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 9 | Room temperatureelectrodeposition of aluminum antimonide compoundsemiconductor显示文摘 | Gandhia T Rajaa K S Misra M | 2008 | Electrochimica Acta2008，53，： | 1 |
| 10 | Two dimensional simulation of a direct-current microhollow cathode discharge显示文摘 | Kothnur P S Rajaa L L | 2005 | J Appl Phys2005，97，04： | 1 |
| 11 | Evaluation of Antibacterial Effects of Ginger Extract When Used as One Component of the Root Canal Sealers ; ( An in vitro Study) 显示文摘 | Wafaa Mohammed Ali Nahla Othman Mohammed Tawfiq Rajaa Taher Sulieman | 2008 | Tikrit Journal of Phar- maceutical Sciences2008，8，2： | 1 |
| 12 | Rapid decolourization and mineralization of the azo dye CI Acid Red 14 by heterogeneous Fenton reaction 显示文摘 | Rajaa I A Manuel V Abdlrani Y | 2011 | Journal of Hazardous Materials2011，186，74： | 1 |
| 13 | The design of power acceptability curves显示文摘 | John K RajaA Gerald H | 2002 | IEEETrans on Power Delivery2002，17，3： | 1 |
| 14 | Sensitive assay for the determination of cefazolin or ceftriaxone in plasma utilizing LC 显示文摘 | Sameer Al-Rawithi Rajaa Hussein Dale A Raines | 2000 | Journal of Pharmaceutical and Biomedical Analysis2000，22，2： | 1 |
| 15 | Oxidative stress is a critical mediator of the angiotensin Ⅱ signal in human neutrophils: in- volvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappa B 显示文摘 | Rajaa EB Moisis A Javier M | 2003 | Blood2003，102，2： | 1 |
| 16 | Hepatitis B genotypes/subgenotypes and MHR variants among Moroccan chronic carriers显示文摘 | Bouchra Kitab Abdellah Essaid El Feydi Rajaa Afifi Omar Derdabi Younes Cherradi Mustapha Benazzouz Khadija Rebbani Ikram Brahim Hanane Salih Alj Fabien Zoulim Christian Trepo Isabelle Chemin Sayeh Ezzikouri Soumaya Benjelloun | 2011 | Journal of Infection2011，，1： | 1 |
| 17 | Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells显示文摘AIM: To examine the ability of cyclin-dependent kinase inhibitor (CDKI) roscovitine (Rosco) to enhance the antitumor effects of conventional chemotherapeutic agents acting by different mechanisms against human colorectal cancer. METHODS: Human colorectal cancer cells were treat-ed, individually and in combination, with Rosco, taxol, 5-Fluorouracil (5-FU), doxorubicine or vinblastine. The antiproliferative effects and the type of interaction of Rosco with tested chemotherapeutic drugs were de-termined. Cell cycle alterations were investigated by fluorescence-activated cell sorter FACS analysis. Apop-tosis was determined by DNA fragmentation assay. RESULTS: Rosco inhibited the proliferation of tumor cells in a time-and dose-dependent manner. The ef-ficacies of all tested chemotherapeutic drugs were markedly enhanced 3.0-8.42 × 103 and 130-5.28 × 103 fold in combination with 5 and 10 μg/mL Rosco, re-spectively. The combination of Rosco and chemothera-peutic drugs inhibited the growth of human colorectal cancer cells in an additive or synergistic fashion, and in a time and dose dependent manner. Rosco induced apoptosis and synergized with tested chemothera-peutic drugs to induce efficient apoptosis in human colorectal cancer cells. Sequential, inverted sequential and simultaneous treatment of cancer cells with combi-nations of chemotherapeutic drugs and Rosco arrested the growth of human colorectal cancer cells at various phases of the cell cycle as follows: Taxol/Rosco (G2/M-and S-phases), 5-FU/Rosco (S-phase), Dox/Rosco (S-phase) and Vinb/Rosco (G2/M-and S-phases). CONCLUSION: Since the eff icacy of many anticancer drugs depends on their ability to induce apoptotic cell death, modulation of this parameter by cell cycle inhibi-tors may provide a novel chemo-preventive and chemo-therapeutic strategy for human colorectal cancer. | Mohamed Salah I Abaza Abdul-Majeed A Bahman Rajaa J Al-Attiyah | 2008 | World Journal of Gastroenterology2008，14，33： | 1 |
| 18 | H 2 O 2 -induced mitochondrial fragmentation in C 2 C 12 myocytes显示文摘 | Xiying Fan Rajaa Hussien George A. Brooks | 2010 | Free Radical Biology and Medicine2010，，11： | 1 |
| 19 | Identification,Diagnostic Potential,and Natural Expression of Immunodominant Seroreactive Peptides Encoded by Five Mycobacterium tuberculosis-Specific Genomic Regions显示文摘 | Noora YA Rajaa A Abu S | | 0，，03： | 1 |
| 20 | Biomimetic approach to per-foration repair using dental pulp stem cells and dentin matrix protein显示文摘 | Rajaa A Sriram R Mohamed IF | 2011 | J Endodontics2011，37，8： | 1 |
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