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您的检索式：作者名="Rajesh R.Naik"
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| 1 | Add-on plasmonic patch as a universal fluorescence enhancer显示文摘Fluorescence-based techniques are the cornerstone of modern biomedical optics,with applications ranging from bioimaging at various scales(organelle to organism)to detection and quantification of a wide variety of biological species of interest.However,the weakness of the fluorescence signal remains a persistent challenge in meeting the ever-increasing demand to image,detect,and quantify biological species with low abundance.Here,we report a simple and universal method based on a flexible and conformal elastomeric film with adsorbed plasmonic nanostructures,which we term a“plasmonic patch,”that provides large(up to 100-fold)and uniform fluorescence enhancement on a variety of surfaces through simple transfer of the plasmonic patch to the surface.We demonstrate the applications of the plasmonic patch in improving the sensitivity and limit of detection(by more than 100 times)of fluorescence-based immunoassays implemented in microtiter plates and in microarray format.The novel fluorescence enhancement approach presented here represents a disease,biomarker,and application agnostic ubiquitously applicable fundamental and enabling technology to immediately improve the sensitivity of existing analytical methodologies in an easy-to-handle and cost-effective manner,without changing the original procedures of the existing techniques. | Jingyi Luan Jeremiah J.Morrissey Zheyu Wang Hamed Gholami Derami Keng-Ku Liu Sisi Cao Qisheng Jiang Congzhou Wang Evan D.Kharasch Rajesh R.Naik Srikanth Singamaneni | 2018 | Light(Science & Applications)2018，7，1： | 0 |
| 2 | 最优化方法在分子识别中的应用(英文)显示文摘分子识别是指两个或多个分子靠非共价键专一地结合在一起.分子识别在物质的形成,细胞信号的传递,基因信息的表达和药物的设计等方面起重要的作用.我们首先对数学和计算方法在分子识别上的应用作了回顾,并从量子力学,经典分子力学和热力学上解释分子识别可转换成一类最优化问题.其次,我们指出了解决这类最优化问题的困难.最后,我们报告了在预报配体与蛋白质识别上所获得的一类新的选择方法.这类方法可将预报的成功率从63%提高到90%. | Zhifeng Kuang Rajesh R.Naik Barry L.Farmer | 2011 | 应用泛函分析学报2011，13，3： | 0 |
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