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| 1 | In vitro α-amylase inhibitory activity and in vivo hypoglycemic effect of methanol extract of Citrus macroptera Montr.fruit显示文摘Objective:To investigate the therapeutic effects of methanol extract of Citrus macroptera Montr,fruit inα-amylase inhibitory activity(in vitro)and hypoglycemic activity in normal and glucose induced hyperglycemic rats(in vivo).Methods:Fruits of Citrus macroptera without rind was extracted with pure methanol following cold extraction and tested for presence of phytochemical constituents,α-amylase inhibitory activity,and hypoglycemic effect in normal rats and glucose induced hyperglycemic rats.Results:Presence of saponin,steroid and terpenoid were identified in the extract.The results showed that fruit extract had moderateα-amylase inhibitory activity[IC_(50)value=(3.638±0.190)mg/mL]as compared to acarbose.Moreover at 500 mg/kg and 1000 mg/kg doses fruit extract significantly(P<0.05 and P<0.01 respectively)reduced fasting blood glucose level in normal rats as compared to glibenclamide(5 mg/kg).In oral glucose tolerance test,500 mg/kg dose significantly reduced blood glucose level(P<0.05)at 2 h but 1000 mg/kg dose significantly reduced blood glucose level at 2 h and 3 h(P<0.05 and P<0.01 respectively)whereas glibenclamide(5 mg/kg)significantly reduced glucose level at every hour after administration.Overall time effect is also considered extremely significant with F value=23.83 and P value=0.0001 in oral glucose tolerance test.Conclusion:These findings suggest that the plant may be a potential source for the development of new oral hypoglycemic agent. | Nizam Uddin Rakib Hasan Monir Hossain Arjyabrata Sarker A.H.M.Nazmul Hasan A.F.M.Mahmudul Islam Mohd.Motaher H.Chowdhury Sohel Rana | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，6： | 4 |
| 2 | Toward simple,generalizable neural networks with universal training for low-SWaP hybrid vision显示文摘Speed,generalizability,and robustness are fundamental issues for building lightweight computational cameras.Here we demonstrate generalizable image reconstruction with the simplest of hybrid machine vision systems:linear optical preprocessors combined with no-hidden-layer,'small-brain' neural networks. Surprisingly,such simple neural networks are capable of learning the image reconstruction from a range of coded diffraction patterns using two masks. We investigate the possibility of generalized or 'universal training' with these small brains. Neural networks trained with sinusoidal or random patterns uniformly distribute errors around a reconstructed image,whereas models trained with a combination of sharp and curved shapes (the phase pattern of optical vortices) reconstruct edges more boldly. We illustrate variable convergence of these simple neural networks and relate learnability of an image to its singular value decomposition entropy of the image. We also provide heuristic experimental results. With thresholding,we achieve robust reconstruction of various disjoint datasets. Our work is favorable for future real-time low size,weight,and power hybrid vision:we reconstruct images on a 15 W laptop CPU with 15,000 frames per second:faster by a factor of 3 than previously reported results and 3 orders of magnitude faster than convolutional neural networks. | BAURZHAN MUMINOV ALTAI PERRY RAKIB HYDER M.SALMAN ASIF LUAT T.VUONG | 2021 | Photonics Research2021，9，7： | 2 |
| 3 | LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol显示文摘The aim of the present investigation was to demonstrate an approach involving use of liquid chromatography(LC) and liquid chromatography-mass spectrometry(LC–MS) to separate, identify and characterize very small quantities of degradation products(DPs) of acebutolol without their isolation from the reaction mixtures. The drug was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions as per International Conference on Harmonization(ICH) guideline Q1 A(R2). Among all the stress conditions the drug was found to be labile in hydrolytic(acidic & basic) and photolytic stress conditions, while it was stable in water-induced hydrolysis, oxidative and thermal stress conditions. A total of four degradation products were formed. A C18 column was employed for the separation of all the DPs on a gradient mode by using high-performance liquid chromatography(HPLC). All the DPs were characterized with the help of their fragmentation pattern and the masses obtained upon LC–MS/MS and MSnanalysis. All the hitherto unknown degradation products were identified as 1-(2-(2-hydroxy-3-(isopropylamino)propoxy)-5-(amino)phenyl)ethanone(DP-I), N-(4-(2-hydroxy-3-(isopropylamino)propoxy)-3-acetylphenyl)acrylamide(DP-II), 1-(2-(2-hydroxy-3-(isopropylamino)propoxy)-5-(hydroxymethylamino)phenyl)ethanone(DP-III) and 1-(6-(2-hydroxy-3-(isopropylamino)propoxy)-2,3-dihydro-2-propylbenzo[d]oxazol-5-yl)ethanone(DP-IV). Finally the in-silico carcinogenicity and hepatotoxicity predictions of the drug and all the DPs were performed by using toxicity prediction softwares viz., TOPKAT, LAZAR and Discovery Studio ADMET. The results of in-silico toxicity studies revealed that acebutolol(0.967) and DP-I(0.986) were found to be carcinogenic, while acebutolol(0.490) and DP-IV(0.437) were found to be hepatotoxic. | Uday Rakibe Ravi Tiwari Anand Mahajan Vipul Rane Pravin Wakte | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 4 | Mixing in a Fltlid Jet Agitated Tank: Effects of Jet Angel and Elevation and Nmnber of Jets 显示文摘 | H D Zughbi M A Rakib | 2004 | Chemical Engineering Science2004，59，4： | 1 |
| 5 | Flame progagation in a rotating gas显示文摘 | SIVASHINSKY G I RAKIB Z MATALON M | 1998 | Combust Sci and Tech1998，57，： | 1 |
| 6 | Purification of fire- fighting water containing a fluorinated surfactant by reverse osmosis coupled to electmcoagulation - filtration 显示文摘 | BAUDEQUIN C COUALLIER E RAKIB M | 2011 | Sep Purif Techno12011，76，3： | 1 |
| 7 | Removal of fluorinated surfactants by reverse osmosis : Role of surfactants in membrane fouling 显示文摘 | BAUDEQUIN C MAI Z H RAKIB M | 2014 | J Membr Sci2014，458，： | 1 |
| 8 | New Porous Ceramics for Tangential Filtration显示文摘 | Rakib S Sghyar M Rafiq M | 2001 | Separation and Purification Technology2001，，25： | 1 |
| 9 | Coupling of bipolar membrane eleetrodialysis and ammonia stripping for direct treatment of wastewaters containing ammonium nitrate 显示文摘 | Ali mab Rakib M Laborie S | 2004 | Journal of Membrane Science2004，244，12： | 1 |
| 10 | Mixing in a fluid jet agitated tank:effects of jet angle and elevation and number of jets显示文摘 | H D Zughbi M A Rakib | 2003 | Chemical Engineering Science2003，，： | 1 |
| 11 | Antiproliferative Action of Conjugated Linoleic Acid on Human MCF-7 Breast Cancer Cells Mediated by Enhancement of Gap Junctional Intercellular Commu- nication through Inactivation of NF-κB显示文摘 | RAKIB MA LEE WS KIM GS | 2013 | Evid Based Complement Alternat Med2013，2013，42： | 1 |
| 12 | An innovative cable modem system for broadband communication 显示文摘 | Rakib S | 1997 | Broadcasting Convention1997，，30： | 1 |
| 13 | New Porous Ceramics for Tangential Filtration显示文摘 | RakibS SghyarM RafiqM | 2001 | Separation and Purificatio Technology2001，，25： | 1 |
| 14 | Analytical model for predicting noise and vibration in permanent magnet synchronous motors显示文摘 | Rakib I Irbil H | 2010 | IEEE Transactions on industry applications2010，46，6： | 1 |
| 15 | A cloud-based DSS model for driver safety and monitoring on Australian roads显示文摘 | Shah J M Rakib A | 2011 | International Journal of Emerging Sciences2011，1，4： | 1 |
| 16 | Purification of firefighting water containing a fluorinated surfactant by reverse osmosis coupled to electrocoagulation-filtration显示文摘 | Baudequin C Couallier E Rakib M | | 0，，03： | 1 |
| 17 | Preventive effect of t,t-conjugated linoleic acid on 12-O-tetradecanoylphorbol-13-acetateinduced inhibition of gap junctional intercellular communication in human mammary epithelial MCF-1 0 A cells显示文摘 | Rakib MA Kim YS Jang WJ | 2011 | J Agric Food Chem2011，59，8： | 1 |
| 18 | A Cloud-based DSS Model for Driver Safety and Monitoring on Australian Roads 显示文摘 | Shah J M Rakib A | 2011 | International Journal of Emerging Sciences2011，1，4： | 1 |
| 19 | Perma- nent-magnet synchronous motor magnet designs with skewing for torque ripple and cogging torque reduction 显示文摘 | RAKIB Islam IQBAL Husain ABBAS Fardoun | 2009 | IEEE Transactions on Industry Applications2009，45，1： | 1 |
| 20 | Attenuation of 12-o-tetradecanoylphorbol-13-acetate (TPA)-induced gap junctional intercellular communication (GJIC) inhibition in MCF-10A cells by c9,tl 1-conjugated linoleic acid显示文摘 | RAKIB M A KIM Y S JANG W J | | 0，，： | 1 |
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