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您的检索式：作者名="Ram Chaulagain"
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| 1 | 开心散乙醇提取物中远志皂苷的入血成分及体内代谢产物分析显示文摘目的:鉴定开心散60%乙醇提取物(KXS-60%E)及其血中移行成分中的远志皂苷类成分,分析大鼠体内远志皂苷类成分的代谢产物。方法:应用UPLC-TOF-MS技术,分析TOF-MS/MS给出的二级离子信息,结合液质联用工作站Mass Lynx v4.1分析软件及现有的文献数据库,鉴定KXS-60%E中远志皂苷类成分、灌服KXS-60%E后血清中的远志皂苷类成分及其代谢产物。结果:鉴定了KXS-60%E中14个远志皂苷类成分,主要为三萜型皂苷;鉴定了大鼠口服KXS-60%E后血中的5个原型皂苷类成分及4个代谢产物。结论:远志皂苷类成分及4个代谢产物可能是KXS-60%E潜在的活性成分及直接药效物质基础,这将有助于阐明开心散防治阿尔兹海默症的有效成分及作用机制。 | Reeju Maharjan Chiranjivi Thapa 汪娜 Ram Chaulagain 薛迪 贾永明 邓竹君 黄树明 刘学伟 | 2017 | 中国实验方剂学杂志2017，23，19： | 13 |
| 2 | UHPLC-MS法鉴定大鼠灌服开心散后血中远志糖酯类化合物及其代谢产物显示文摘本研究利用超高效液相色谱-飞行时间质谱联用技术(UHPLC-TOF/MS),借助液质联用工作站Masslynx V4.1分析软件,结合现有文献及相关数据库,鉴定了开心散60%乙醇提取物(KXS-60%E)中20个远志糖酯类成分;在此基础上,进一步指认并鉴定了灌服KXS-60%E后大鼠血中的14个远志糖酯类化合物及4个来源于远志糖酯类成分的代谢产物。以上研究结果表明,远志糖酯类化合物及其代谢产物是KXS-60%E的主要血中移行成分,原形及代谢产物可能是开心散防治AD的潜在药效物质基础。 | 汪娜 Hassan AHMAD 贾永明 薛迪 Ram CHAULAGAIN 黄树明 刘学伟 | 2017 | 药学学报2017，52，10： | 11 |
| 3 | Local Adaptation Mechanisms to Address Climate Led Food Insecurity in Far-western Nepal:The Case of Badimalika Municipality显示文摘The study was carried out to understand the food security situation and coping mechanisms due to an effect of climate change on food security of Badimalika Municipality of Bajura district in the far-western region;an acute food deficit district of Nepal.Literature review,household questionnaire survey to document primary data,stakeholders’consultation with field observations were the principle methods applied to explore the possible adaptation measures for securing food and livelihood of people.The research revealed that the district is food insecure for at least six to nine months of a year which is worsened by climate induced natural disasters:flood,landslides and drought.Sudden and unpredictable precipitation both in winter and monsoon has distorted the productions over the years.Considerable proportions of grazing land and forested area have been converted into farmland especially in the highlands.Migrating working class manpower to India to seek livelihoods is a menace to development in the place while seasonal migration in and outside the country is an interesting adaptive mechanism in the district.Drought resistant crop varieties such as Finger Millet(Elusine coracana),Foxtail Millet(Setaria italic L.),Wheat(Triticum aestivum),and Amaranth(Amaranthus sp.)are highly potential cereal crops that need to be promoted.Some humanitarian agencies with the support of GoN have been playing an important role in reducing the impact of food deficiency in the region.National Food Corporation District Office supplies the deficit quantity of food to the people.The government needs to make agriculture the highest priority with increased investment schemes to avert the looming food crisis with emphasis on further research based activities through understanding the impact of climate change on specific crops and respective technological interventions,incorporating local adaptation mechanisms for disasters and climate change.Slow-forming terraces,conservation tillage,crop diversification,selection and promotion of drought-resistant varieties of crops,ecological pest management,seed and grain storages etc.are some technological innovations to be considered for enhancing food security. | Deepak Chaulagain Parshu Ram Rimal | 2019 | Journal of Food Science and Engineering2019，9，1： | 0 |
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