| 1 | Formulation development of multi unit particulate system(MUPS) for anti-diabetic drugs显示文摘Metformin hydrochloride and sitagliptin phosphate is the common combination among diabetic drugs.Available dosage forms cannot avoid the dose dumping which leads to the complication such as lactic acidosis,gastrointestinal complication,and severe hypoglycemia.Metformin hydrochloride has a very short half-life,i.e.4 hrs,and thus fails to give action for the long period.This leads to the increase number of dosings per day.Single-unit formulations contain the active ingredient within the single tablet or capsule,whereasmultiple-unit dosage forms comprise a number of discrete particles that are combined into one dosage unit. | Surendra Agrawal Ketaki Joshi Ram Gaud | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，1： | 1 |
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