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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | MicroRNA control of lymphocyte differentiation and function显示文摘 | Belver L Papavasiliou F N Ramiro A R | 2011 | Curr Opin Immunol2011，23，3： | 1 |
| 3 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 4 | MicroRNAs prevent tbe generation of autoreactive antibodies 显示文摘 | Belver L de Yebenes VG Ramiro AR | 2010 | Immunity2010，33，： | 1 |
| 5 | Effect of photo oxida- tive stress induced by paraquat in two wheat cultivars with differential tolerance to water stress显示文摘 | Ramiro H L Mariana N M Celina M L | 2003 | Plant Science2003，164，： | 1 |
| 6 | Effect of photooxidative stress induced by paraquat in two wheat cultivars with differential to1erance to water stress显示文摘 | Ramiro H L Mariana N M Celina M L et a1 | 2003 | Plant Science2003，164，： | 1 |
| 7 | basal ganglia haematornas in severely head injured patients: clinieoradiologieal analysis of 37 cases显示文摘 | Gregorio R B Ramiro D L Juan J R | 2001 | J neurosurg2001，94，： | 1 |
| 8 | Effect of photooxidative stress induced by paraquat in two wheat cuhivars with differential tolerance to water stress显示文摘 | Ramiro H L Mariana N M Celina M L | 2003 | Plant Science2003，164，： | 1 |
| 9 | Long-term results of thalidomide in refractory and relapsed multiple myeloma with emphasis on response duration显示文摘 | Cibeira MT Rosino IL Ramiro L | 2006 | Eur J Haematol2006，77，5： | 1 |
| 10 | MicroRNAs prevent the generation of autoreactive antibodies 显示文摘 | Belver L de Y6benes V G Ramiro A R | 2010 | Immunity2010，33，5： | 1 |
| 11 | Soil seed banks in the semi-arid Prepuna of Bolivia显示文摘 | Ramiro P L | 2003 | Plant Ecology2003，168，： | 1 |
| 12 | Influence of the regeneration temperature on the phenols adsorption on activated carbon显示文摘 | Sabio E Gonz alez-Martiny M L Ramiro A | 2001 | Journal of Colloid and Interface Science2001，242，： | 1 |
| 13 | Influence of regeneration temperature on the phenols adsorption on activated carbon 显示文摘 | Sabio E Martin M L G Ramiro A | 2001 | Colloid Interface Sci2001，，242： | 1 |
| 14 | MicroRNAs prevent the generation of autoreactive antibodies显示文摘 | Belver L de Ybenes VG Ramiro AR | 2010 | Immunity2010，33，5： | 1 |
| 15 | Influence of regeneration temperature on the phenols adsorption on activated carbon 显示文摘 | E Sabio M L G Martin A Ramiro | 2001 | Colloid Interface Science2001，24，2： | 1 |
| 16 | Influence of the regeneration temperature on the phenols adsorption on activated catbon显示文摘 | Sabio E Gonzalez Martin M L Ramiro A | 2001 | Journal of Colloid and Interface Science2001，242，： | 1 |
| 17 | Geometric attacks on image watermarking systems显示文摘 | Vinicius L Ramiro J | 2005 | IEEE MultiMedia2005，7，： | 1 |
| 18 | Data mining for grammatical inference with bioinformatics criteria显示文摘 | Vivian F. López Ramiro Aguilar Luis Alonso María N. Moreno | 2011 | Expert Systems With Applications2011，，3： | 1 |
| 19 | Development and validation of a morphological model for multiple sediment classes显示文摘The complexity of sediment dynamics in aquatic systems can be better understood by applying numerical models. The development of a comprehensive morphological model is presented in this paper.The model aims to predict the sediment transport and bed evolution in natural systems composed of different sediment types. The morphological model was implemented in MOHID, a modelling system that solves the three-dimensional hydrodynamics and advection-diffusion transport of suspended sediments. Multiple sediment classes were taken into account(non-cohesive and cohesive) considering the effects of sediment mixtures and bed consolidation on resistance to erosion. To represent bottom stratigraphy, the bottom column can be divided into several layers. The key points of the simulated processes are discussed in this paper. Model results are assessed in six test cases through comparison with analytic solutions or experimental data. The outcomes demonstrate the model's capacity to simulate the transport dynamics of non-cohesive and cohesive sediments. The speed up of morphological changes by an acceleration factor permitted modelling bed evolution for long time periods.Moreover, a test case for the Tagus Estuary demonstrated the model's capacity for generating realistic sediment distribution based on the local hydrodynamic conditions. Limitations in the availability of bed composition data can be overcome by considering a warm-up run to provide realistic initial conditions for further predictions of morphological developments. | Guilherme Franz Paulo Leitao Lígia Pinto Eduardo Jauch Luís Fernandes ramiro neves | 2017 | International Journal of Sediment Research2017，32，4： | 1 |
| 20 | Influence of regeneration temperature on the phenols adsorption on activated carbon显示文摘 | E Sabio M L G Martin A Ramiro | | 0，，02： | 1 |
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