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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | A study on the glycaemie balance in streptozotocin-diabetic rats treated with an aqueous extract of Ficus carica (fig tree) leaves显示文摘 | Perez C Dominguez E Ramiro J M | 1996 | Phyto- ther Res1996，10，： | 1 |
| 3 | Calprotectin in rheumatoid rthritis :association with disease activity in a cross- sectional and a longitudinal cohort 显示文摘 | Garcia-Arias M Pascual-Salcedo D Ramiro S | 2013 | Mol Diagn Ther2013，17，1： | 1 |
| 4 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 5 | Pyrolysis gasification of agricultural residues by carbon dioxide in the presence of different additives:influence of variables显示文摘 | Encinar J M Beltran F J Ramiro A | 1998 | Fuel Processing Technology1998，55，3： | 1 |
| 6 | Use of energy crops for domestic heating with a mural boiler 显示文摘 | Juan F GonzOlez Carmen M GonzOlez-Garcta Antonio Ramiro et a/ | 2006 | Fuel Processing Technology2006，87，8： | 1 |
| 7 | Excess copper effect on growth, chloroplast ultrastructure, oxygen-evolution activity and chlorophyll fluorescence in Glycine max cell suspensions 显示文摘 | Bernal M Ramiro MV Cases R Picorel R Yruela I | 2006 | Physiol Plant2006，127，2： | 1 |
| 8 | Catprotectin in rheumatoid arthritis : association with disease activity in a cross-sectional and a longitudinal cohort显示文摘 | Garcia-Arias M Pascual-Salcedo D Ramiro S | 2013 | Mol Diagn Ther2013，17，1： | 1 |
| 9 | Effect of photo oxida- tive stress induced by paraquat in two wheat cultivars with differential tolerance to water stress显示文摘 | Ramiro H L Mariana N M Celina M L | 2003 | Plant Science2003，164，： | 1 |
| 10 | Effect of photooxidative stress induced by paraquat in two wheat cultivars with differential to1erance to water stress显示文摘 | Ramiro H L Mariana N M Celina M L et a1 | 2003 | Plant Science2003，164，： | 1 |
| 11 | Pyrolysis-gasification of agricultural residues by carbon dioxide in the presence of different additives: influence of variables显示文摘 | ENCINAR J M BELTRAN F J RAMIRO A | 1998 | Fuel Processing Technology1998，55，： | 1 |
| 12 | Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery 显示文摘 | Pouya N Dayani M Ramiro maldonado M | 2009 | Retina2009，29，10： | 1 |
| 13 | Removal of Cd( Ⅱ ) , Zn ( Ⅱ ) and Pb ( Ⅱ ) from aqueous solutions by brown marine macro algae: kinetic modeling显示文摘 | Olga M M F Ramiro J E M Cristina M | 2008 | Journal of Hazardous Materials2008，153，： | 1 |
| 14 | Role of genomic instability and p53 in AID-induced c-myc-Igh translocations 显示文摘 | Ramiro AR Jankovic M Callen E | 2006 | Nature2006，440，7080： | 1 |
| 15 | AID is re-quired for c-myc/IgH chromosome translocations in vivo显示文摘 | Ramiro AR Jankovic M Eisenreich T | 2004 | Cell2004，118，： | 1 |
| 16 | Pyrolysis of two agricultural residues:Olive and grape bagasse:Influence of particle size and temperature显示文摘 | ENCINAR J M BELTRAN F J BERNALTE A RAMIRO A GONZALEZ J F | 1996 | Biomass Bioenergy1996，11，5： | 1 |
| 17 | A high-density collection of EMS-induced mutations for TILLING in Landsberg erecta genetic background of Arabidopsis 显示文摘 | Martin B Ramiro M Martinez-Zapater J M | 2009 | BMC Plant Biol2009，9，： | 1 |
| 18 | Gram-stain plus MALDI-TOF MS(matrix-assisted laser desorption ionization-time of flight mass spectrometry)for a rapid diagnosis of urinary tract infection显示文摘 | Burillo A Rodríguez-Sánchez B Ramiro A Cercenado E Rodríguez-Créixems M Bouza E | 2014 | PLo S One2014，9，86： | 1 |
| 19 | Pyrolysis/gasification of Agricultural Residues by Carbon Dioxide in the Presence of Different Additives:Influence of Variables显示文摘 | Encinar J M Beltrán F J Ramiro A | 1998 | Fuel Processing Technology1998，55，3： | 1 |
| 20 | Weather data and energy balance of a hybrid photovoltaic-wind system with hydrogen storage 显示文摘 | M Calder6n A J Calder6n A Ramiro | 2010 | International Journal of Hydrogen Energy2010，，35： | 1 |
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